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The 8 Best bed bug killer sprays of 2025

Are you trying to find bed bug killer sprays among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling bed bug killer sprays on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 11 hours of research and did 54 bed bug killer sprays tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best bed bug killer sprays you can buy today

SaleNo. 1
Ortho Home Defense Max Bed Bug, Flea and Tick Killer with Comfort Wand, Bed Bug Spray, Kills Bed Bug Eggs, Fleas and Ticks, 1 gal.
  • Kill bed bugs, bed bug eggs, fleas and ticks with Ortho Home Defense Max Bed Bug, Flea & Tick Killer
  • This bed bug spray kills even the toughest bed bugs (pyrethroid-resistant bed bugs)
  • Use this indoor bug killer as a spot treatment around bed frames, baseboards and mattress seams, tufts and folds
  • Apply insect spray using the included Comfort Wand to target tight and hard-to-reach places where bed bugs hide
  • Ortho Home Defense Max Bed Bug, Flea & Tick Killer is a Step 2 product in the Ortho Bed Bug Solution System; use with Step 1: Detect and Trap and Step 3: Cracks and Crevices products for best results
No. 2
Hot Shot Ready-to-Use Bed Bug Killer Spray, Kills Bed Bugs and Bed Bug Eggs, Kills Fleas and Dust Mites, 32 Ounce
  • Bed bug treatment: Hot Shot bed bug Killer with egg kill kills bed bugs and bed bug eggs, adult and pre-adult (larvae) fleas and Dust mites
  • Use indoors: spot treat mattress tufts, folds, vent holes, buttons, creases, indentations and seams – do not use on pets
  • Water-based formula: this non-staining formula leaves no odor
  • Application: spray intended use areas until damp, but do not saturate – inspect the area and apply every two weeks while bed bugs are present
  • Treat bed bugs as part of a cycle: for Best results, use this product as part of a comprehensive bed bug treatment plan — treating bed bugs as part of a cycle is key to gaining control
SaleNo. 3
Harris Toughest Bed Bug Killer, Liquid Spray with Odorless and Non-Staining Extended Residual Kill Formula (Gallon)
  • Kills Resistant Bed Bugs & Their Eggs - Kills even the toughest "pyrethroid resistant" bed bugs and eggs that have built up a resistance to traditional pesticides
  • Kills Quickly - Knocks down bed bugs fast when sprayed directly
  • Long Residual - Continues to kill bed bugs for up to 16 weeks after initial application
  • Odorless Formula - Odorless and non-staining formula will not cause damage to fabrics when used according to label directions
SaleNo. 4
Ecologic Bed Bug Killer, Kills Bed Bugs & Bed Bug Eggs, Use on Mattresses, Bed Frames, Suitcases and More, Aerosol Spray, 14 fl Ounce
  • KILLS BED BUGS BY CONTACT: Aerosol spray kills bed bugs by contact, including pyrethroid-resistant bed bug and bed bug eggs.
  • TREAT CRACKS AND CREVICES: Apply as a spot treatment to cracks and crevices around baseboards, floorboards, bedboards, carpet edges, walls and more.
  • TREAT MATTRESSES: Use on mattresses, box springs, bed frames and luggage as listed.
  • ACTIVE INGREDIENTS: Formulated with lemongrass oil and cornmint oil.
  • SAFE AROUND KIDS AND PETS: When used and stored as directed.
SaleNo. 5
Hot Shot Bed Bug Killer Aerosol, Bed Bug Treatment, 17.5 oz
  • This product kills bed bugs and bed bug eggs, as well as crawling insects, brown dog ticks, fleas, dust mites, clothes moths and carpet beetles. Use as part of a bed bug treatment
  • For use on mattresses, wood furniture and carpet. This product can also be used on bed frames, headboards, floors, moldings, ceiling and walls
  • Controls bed bugs for up to 3 weeks on carpeted surfaces
  • Non-staining, no unpleasant odor
SaleNo. 6
MGK Crossfire® Bed Bug Concentrate | Kills Pyrethroid-Resistant Bed Bug Strains | 13 oz | Non-Staining
  • PATENTED FORMULA: CrossFire bed bug spray kills pyrethroid-resistant bed bug strains at all life stages, including eggs. With its two active ingredients and a synergist, get effective bed bug control.
  • QUICK KNOCKDOWN AND KILL: Begins working within minutes of exposure. This professional product is backed by multiple active ingredients.
  • NON-STAINING: For indoor use in residential, institutional and commercial facilities, this bed bugs killer treatment is approved for direct application onto mattresses.
  • EASY TO MIX AND USE: One 13-ounce bottle of bed bug concentrate makes one gallon of finished product.
  • A LEGACY YOU CAN TRUST: Driven by expertise and industry commitment, MGK has been developing pest control products based primarily on botanical and innovative technologies since 1902.
No. 7
Kate's Home & Garden Bed Bug Killer for Mattress (16oz) Repel and Kill Indoor Infestation with Natural & Non-Toxic Bed Bug Killer Spray. Made in USA
  • KILL BED BUG WITH GERANIOL AND CEDARWOOD OIL: Geranoil and cedarwood oil can kill bed bugs and prevent infestation. However, the scent can be strong so make sure to open the window to let the air circulate.
  • SAFE AROUND PETS & PEOPLE - Made with natural ingredients to eradicate bed bug infestations on mattresses and indoor furnitures. Spray on hotel beds when travelling to repel bed bug bites.
  • KILL ALL STAGES OF BED BUGS — Kills bed bug adults and nymphs fast on contact. Also attack eggs.
  • PROTECT HOUSEHOLD FURNITURES FROM BED BUGS: Spray Bed Bug Killer on your furniture, beds, mattresses to protect against Bed Bugs.
  • EFFECTIVE SPOT TREATMENTS: Spray around bed frames, baseboards, headboards, and hotel beds where bed bugs are prevalent.
No. 8
Say Bye Bugs Bed Bug Killer Spray (1x 16oz) - Kills on Contact. Non-Toxic Formula, Safe for Family and Pets. Leaves No Odor, No Stains. Simple - Shake & Spray System. Made in The USA.
  • ✅ EFFICIENT: University and Laboratory Proven Bed Bug Spray that Kills Bed Bugs Instantly 🎯. Eliminates Bed Bugs in All Stages of Development.
  • ✅ PET & FAMILY SAFE: Non-toxic when used as directed. Minimum-Risk Pesticide according to 40 CFR 152.25(f). Contains only ingredients generally recognized as safe.
  • ✅ TRACELESS: Odor and Stain FREE Bed Bug Spray for Furniture and Bedding, clothing and bedsheets.
  • ✅ ESTABLISHED US BRAND: SayByeBugs bed spray Helped 250.000 Homes get rid of Bed Bugs in the past 7+ years. Made in the USA.
  • ✅ ENVIRONMENTALLY FRIENDLY: Biodegradable bug spray for home.
SaleNo. 9
Bed Bug Killer Spray by Premo Guard 16 oz – Fast Acting Bed Bug Treatment – Stain & Scent Free – Child & Pet Safe – Best Extended Protection – Natural & Non Toxic Formula
  • NATURAL. Made from natural ingredients. Use for entire home, farm, yard, travel, public housing, shelters, and other group home environments.
  • SAFE FOR FAMILY and PETS. You can use our bed bug spray with confidence and with peace of mind knowing that it is safe to use around the home, children and animals. Made 100% in the USA.
  • STAIN and SCENT FREE. When used according to label directions the spray will not stain bedding, pillows and other fabrics. Apply directly to sheets, mattress, pillow covers, pet bedding, carpets, furniture, curtains, etc. Scent free with no harmful fumes that come from traditional treatment products.
  • POWERFUL BUG KILLER. Kills bugs in all life stages (eggs, nymphs, adults). Kills bed bugs and mites effectively and fast on contact when sprayed directly onto bug.
  • EFFECTTIVE RESULTS. Our products are safe and are formulated using quality standards.
SaleNo. 10
Nix Lice & Bedbug Killing Spray for Home, Bedding & Furniture, 5 fl oz
  • Nix Lice & Bedbug Killing Spray for Home kills lice and bedbugs in your home
  • Nix lice treatment killing spray for the home has no odor, is non-staining and leaves no sticky residue when it is sprayed
  • Kills lice and bedbugs on furniture and bedding and is effective for up to 4 weeks
  • Easy to use — simply spray affected bedbug and lice areas; not for use on humans
  • Nix is the number one pediatrician-recommended lice removal brand* * Based on Pediatrician Survey December 6, 2022
No. 11
Bed Bug Travel Spray by Bed Bug Patrol - Natural Bed Bug Killer - Child & Pet Safe - Plant Based - Non-Toxic - TSA Approved - for Hotels, Airbnb, Rideshare, Luggage - 3oz Travel Size
  • PROVEN TO BE EFFECTIVE — The Journal of Economic Entomology Published an Independent Study by Rutgers Entomology Department, Which Confirmed Bed Bug Patrol Is "The Most Effective Essential Oil-Based Pesticide" On The Market. Bed Bug Patrol's 100% Natural, Proprietary Formula Eradicates Bedbugs in Every Cycle, from Egg and Nymph to Pesticide-Resistant Mutating Adults. Helping to Prevent Future Outbreaks of Bed Bugs Fast.
  • TSA APPROVED & PERFECT SIZE FOR TRAVEL PROTECTION — Bed Bug Patrol Travel Spray is Sized Specifically to Meet The 3.2 oz Liquid Travel Limitations Imposed by TSA While Still Packing Enough Power to Protect Even The Worst Hotel Rooms and Uber / Lyft Trips From Current and Future Infestations.
  • OUR PRODUCT IS 100% PLANT-BASED & NON-TOXIC — Bed Bug Patrol Is Made In the USA, Using Natural and Non-Toxic Ingredients (Including Natural Peppermint Oil and Clove Oil). Child and Pet Safe With No More Worries About Toxic Fumes Or Dangerous Chemicals. Our Product Is Effective at Stopping Bed Bug Problems In Their Tracks.
  • BE ASSURED OUR PRODUCT IS FAMILY, CHILD & PET SAFE — You Will Have No More Worries about Toxic Fumes or Dangerous Chemicals Coming in Contact With You and Your Family or Pets. Rest Assured, You Are Buying an EPA Exempt 25b Minimum Risk Pesticide Safe and Effective.
  • UNIVERSITY & LAB TESTED — Rutgers University and Snell Scientifics, Inc. Each Conducted Independent Treatment Tests of Bed Bug Patrol Natural Bug Killer. Bed Bug Patrol Has an Impressive Mortality Rate of 83%, Killing Bed Bugs Within 30 Minutes After Application and 98% Within the First Four Hours. Upon Completion of the Study, Bed Bug Patrol Bed Bug Killer Demonstrated a 100% Kill Rate on Bed Bugs.
  • STAIN-FREE* — Our One-Of-A-Kind Formula Can Be Used On Any Water-Safe Surface, Including Upholstery, Mattresses, Bed Linens, Clothing, Walls, Etc. Spray a Light Mist and Watch as Our Product Leaves Nothing But a Pleasant Peppermint Scent Along With Destroyed Bed Bugs. *As With All New Products, Please Do A Small Discreet Patch Test On Any Fabric/Material Before First Use.
  • DOWNLOAD OUR STEP-BY-STEP EBOOK: — Scan Our QR Code on the Product Card Shipped with the Product to Receive Your Free Digital PDF eBook on How to Get Rid of Bed Bugs Quickly. This eBook Gives You an In-Depth Look About Bed Bugs and How to Effectively Win Your Bed Bug Battle Rapidly.
  • WE STAND BEHIND OUR PRODUCTS: — We Stand Behind Our Bed Bug Killer Products.. If, For Any Reason You Are Not Completely Satisfied, Please Reach Out to Us Directly So We Can Assist You With Expediting That Refund Easily.
No. 12
Raid Max Bed Bug Extended Protection, Kills Bed Bugs for 8 weeks on Laminated Woods and Surfaces, 22 Oz
  • Kills bed bugs & their eggs
  • Kills by contact
  • Keeps killing bed bugs for up to 8 weeks
  • Scientifically formulated to kill Parathyroid-resistant Bed Bug strains
SaleNo. 13
HARRIS Bed Bug Killer, Liquid Spray with Odorless and Non-Staining Formula (Gallon)
  • Kills Bed Bugs When Spray Dries - The spray will kill once completely dried
  • Great Value - 1 Gallon allows for repeated applications on an on-going basis to effectively eliminate bed bugs
  • Odorless Formula - Odorless and non-staining formula will not cause damage to fabrics when used according to label directions
  • EPA Registered - Registered with the Environmental Protection Agency (No. 3-11) for indoor residential use
  • Extended Trigger Sprayer - Use the included trigger sprayer to effectively treat areas where bed bugs are hiding
No. 14
Ecologic Bed Bug Killer 64 Ounces, Ready-To-Use Spray, Kills Pyrethroid-Resistant Bed Bugs And Eggs
  • KILLS BED BUGS BY CONTACT: Ready-to-use spray kills bed bugs by contact, including pyrethroid-resistant bed bug and bed bug eggs, along with fleas.
  • TREAT CRACKS AND CREVICES: Apply as a spot treatment to cracks and crevices around baseboards, floorboards, bedboards, carpet edges, walls and more.
  • TREAT MATTRESSES: Use on mattresses, box springs, bed frames and luggage as listed.
  • ACTIVE INGREDIENTS: Formulated with lemongrass oil and cornmint oil.
  • SAFE AROUND KIDS AND PETS: When used and stored as directed.
No. 15
EcoRaider Bed Bug Killer Spray 16 Oz, Green + Non-toxic, 100% Kill + Extended Protection
  • THE MOST EFFECTIVE BED BUG KILLER — Entomological Society of America's journal publication confirmed that EcoRaider is the only natural product that kills bed bugs with 100% efficacy.
  • PROVEN THROUGH USDA IR4 PHP PROGRAM — field tested by research entomologists for eradicating bed bug infestations in public housing buildings and recommend for sensitive environment.
  • KILL ALL STAGES INCLUSIVE & EVEN RESISTANT BED BUGS — Kills adults, nymphs fast on contact with 100% efficacy, kills bed bugs that are resistant to traditional pesticides. Highest performance in eliminating bed bug eggs. EXTENDED DRY RESIDUAL PROTECTION — University study shows EcoRaider residual provides extended
  • EXTENDED DRY RESIDUAL PROTECTION — University study shows EcoRaider residual provides extended protection for two weeks on bed bugs even after dried.
  • NON-TOXIC, SAFE AND ECO-FRIENDLY — certified USDA BioBased insecticide, dermatologically safe; child and pet friendly; safe to use directly on mattress and box springs.
SaleNo. 16
Harris 5 Minute Bed Bug Killer, Odorless & Non Staining Formula (128oz)
  • 5 Minute Kill Time – Kills bed bugs at all life stages in 5 minutes after direct contact
  • Patent Pending Technology – Uses metofluthrin, clothianidin and piperonyl butoxide
  • Residual Kill – The EPA claim for the residual of the product is 1 month
  • EPA Registered – Registered with the Environmental Protection Agency (No. 1021-2793-3) for use in homes
  • Harris Exclusive – Harris has an exclusive on this formula in the retail market
No. 17
Grandpa Gus's Natural Bed Bug Killer Spray, 48 Hours Time-Release Plant-Based Actives, Kills Bed Bugs & Their Eggs, 16 fl oz
  • Kills bed bugs, even pyrethroid-resistant bed bugs & eggs by contact. Grandpa Gus's Bed Bug Killer Spray is laboratory-tested to kill bed bugs as well as a pyrethroid bed bug spray and better than a natural bed bug spray killer spray
  • Grandpa Gus's Bed Bug Killer Spray steadily releases nature's own protective ingredients over time to quickly kill bed bugs and their eggs. Made in the USA
  • 100% plant-based actives. Active essential oil Geraniol, a highly powerful insecticide, works with Lemongrass and Citronella to kill bed bugs for up to 48 hours
  • Safe for use around kids and pets, when used as directed. Our simple, natural ingredients are toxic to bugs, not people or pets. Once the spray has dried, children and pets can return to the area of application. Spray will not harm fabrics
  • Natural, simple solutions. Grandpa Gus set out to create new formulas that really work using natural ingredients and plant-based actives that are simple and safe for the family to use no matter what, worry free!
No. 18
Raid Max Bed Bug Crack & Crevice Extended Protection Foaming Spray, Kills Bed Bugs for up to 8 weeks on Laminated Woods and Surfaces, 17.5 oz
  • Kills bed bugs and their eggs, protecting against infestations
  • Keeps eliminating bed bugs for up to 8 weeks on laminated wood surfaces
  • Dries clear, leaving no messy residue
  • Foaming texture expands to target hard-to-reach areas
  • Precision nozzle is perfect for spot treatment, or reaching into cracks and crevices
SaleNo. 19
Harris Bed Bug and Egg Killer, 16oz Aerosol Spray
  • Kills Bed Bugs & Their Eggs When Spray Dries - The spray will kill once completely dry
  • EPA Registered - Registered with the Environmental Protection Agency (No. 1021-1767-3) for indoor residential use
  • Variety of Surface Applications - Apply as a surface spray to luggage, mattresses, furniture, box springs and more. See label for full list.
  • High Pressure Aerosol - High pressure aerosol spray helps to treat deep into cracks and crevices where bed bugs are hiding
  • For Indoor Use - Intended for indoor residential use according to label instructions
No. 20
PT Alpine Flea & Bed Bug Pressurized Insecticide - 20 oz.
  • Safe for Pets
  • Kills fleas for up to 30 days, Kills hatching flea eggs for up to 7 months, Kills bed bugs, Aids in preventing bed bug hatch
  • Prallethrin for quick knockdown.Long-lasting IGR pyriproxyfen kills hatching eggs for up to seven months.
  • 20 Oz Can Treats 2,625 square feet
  • Use In: Apartments, Commercial Structures, Homes, Hotels, Kennels, Motels and Veterinary

How to choose a good bed bug killer sprays

Does the idea of finding a fantastic bed bug killer sprays make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in bed bug killer sprays. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top bed bug killer sprays products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top bed bug killer sprays on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top bed bug killer sprays brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top bed bug killer sprays based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the bed bug killer sprays were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good bed bug killer sprays, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your bed bug killer sprays.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting bed bug killer sprays for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our bed bug killer sprays. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what bed bug killer sprays should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on bed bug killer sprays.