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The 8 Best bed bug spray for mattress of 2024

Are you trying to find bed bug spray for mattress among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling bed bug spray for mattress on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 20 hours of research and did 18 bed bug spray for mattress tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best bed bug spray for mattress you can buy today

SaleNo. 1
Ortho Home Defense Max Bed Bug, Flea and Tick Killer with Comfort Wand, Bed Bug Killer Spray, 1 gal., Purple
  • Use Ortho Home Defense Max Bed Bug, Flea & Tick Killer to kill bed bugs, bed bug eggs, fleas, and ticks
  • Use spray as a spot treatment around bed frames, mattress seams/tufts/folds, and baseboards
  • Kills even the toughest bed bugs (pyrethroid-resistant bed bugs)
  • Second step of a 3-step bed bug solution system
  • The continuous spray Comfort Wand easily gets into hard-to-reach areas
No. 2
Bed Bug Killer 16 oz EcoVenger by EcoRaider, 100% Kill Efficacy, Bedbugs & Mites, Eggs & The Resistant, Lasting Protection, USDA BIO-Certified, Plant Extract Based & Non-Toxic, Child & Pet Safe
  • PROVEN THROUGH USDA IR4 PHP PROGRAM — field tested by research entomologists for eradicating bed bug infestations in public housing buildings and recommend for sensitive environment
  • KILL ALL STAGES INCLUSIVE & EVEN RESISTANT BED BUGS — Kills bed bug adults and nymphs fast on contact with 100% efficacy, kills bed bugs that are resistant to traditional pesticides. Proven highest performance in eliminating bed bug eggs
  • EXTENDED DRY RESIDUAL PROTECTION — University study shows EcoRaider residual provides extended protection for two weeks on bed bugs even after dried
  • NON-TOXIC, SAFE AND ECO-FRIENDLY — certified USDA BioBased insecticide, dermatologically safe; child and pet friendly; safe to use directly on mattress and box springs.
  • INGREDIENTS: Geraniol, Cedarwood oil, Sodium Lauryl Sulfate, Glyceryl dicaprylate, Silica hydrate, Glyceryl monooleate and water.
No. 3
Hot Shot Ready-to-Use Bed Bug Killer Spray, Kills Bed Bugs and Bed Bug Eggs, Kills Fleas and Dust Mites, 32 Ounce
  • Bed bug treatment: Hot Shot bed bug Killer with egg kill kills bed bugs and bed bug eggs, adult and pre-adult (larvae) fleas and Dust mites
  • Use indoors: spot treat mattress tufts, folds, vent holes, buttons, creases, indentations and seams – do not use on pets
  • Water-based formula: this non-staining formula leaves no odor
  • Application: spray intended use areas until damp, but do not saturate – inspect the area and apply every two weeks while bed bugs are present
  • Treat bed bugs as part of a cycle: for Best results, use this product as part of a comprehensive bed bug treatment plan — treating bed bugs as part of a cycle is key to gaining control
No. 4
Ecologic Bed Bug Killer, Kills Bed Bugs & Bed Bug Eggs, Use on Mattresses, Bed Frames, Suitcases and More, Aerosol Spray, 14 fl Ounce
  • KILLS BED BUGS BY CONTACT: Aerosol spray kills bed bugs by contact, including pyrethroid-resistant bed bug and bed bug eggs.
  • TREAT CRACKS AND CREVICES: Apply as a spot treatment to cracks and crevices around baseboards, floorboards, bedboards, carpet edges, walls and more.
  • TREAT MATTRESSES: Use on mattresses, box springs, bed frames and luggage as listed.
  • ACTIVE INGREDIENTS: Formulated with lemongrass oil and cornmint oil.
  • SAFE AROUND KIDS AND PETS: When used and stored as directed.
SaleNo. 5
Eco Defense Bed Bug Killer - USDA Biobased, Bed Bug Spray & Dust Mite Spray - Natural Repellent Treatment - 16 oz
  • KILLS ON CONTACT - Natural ingredients eliminate bed bugs on contact in all stages of life, Eggs, Nymphs, and Adults.
  • NON STAINING - Won't stain your bedding like some products on the market. Apply directly to sheets, mattress and cover to kill bed bugs on site.
  • SLEEP SECURE - Made of completely natural as well as organic based ingredients. No worries of fumes or dangerous pesticides and chemicals coming in contact with you and your family.
  • FASTEST TREATMENT - Eco Defense Bed Bug Killer Spray works extremely fast and is easy to use. Many customers have found it easier to use and more effective than other Bed Bug products including, Bed Bug Powders, Bed Bug Traps, and Bed Bug Foggers. Rest assured, Eco Defense is your #1 solution.
No. 6
Kate's Home & Garden Bed Bug Killer for Mattress (16oz) Repel and Kill Indoor Infestation with Natural & Non-Toxic Bed Bug Killer Spray. Made in USA
  • KILL BED BUG WITH GERANIOL AND CEDARWOOD OIL: Geranoil and cedarwood oil can kill bed bugs and prevent infestation. However, the scent can be strong so make sure to open the window to let the air circulate.
  • SAFE AROUND PETS & PEOPLE - Made with natural ingredients to eradicate bed bug infestations on mattresses and indoor furnitures. Spray on hotel beds when travelling to repel bed bug bites.
  • KILL ALL STAGES OF BED BUGS — Kills bed bug adults and nymphs fast on contact. Also attack eggs.
  • PROTECT HOUSEHOLD FURNITURES FROM BED BUGS: Spray Bed Bug Killer on your furniture, beds, mattresses to protect against Bed Bugs.
  • EFFECTIVE SPOT TREATMENTS: Spray around bed frames, baseboards, headboards, and hotel beds where bed bugs are prevalent.
No. 7
Nix Lice & Bedbug Killing Spray for Home, Bedding & Furniture, 5 fl oz
  • Nix Lice & Bedbug Killing Spray for Home kills lice and bedbugs in your home
  • Nix lice treatment killing spray for the home has no odor, is non-staining and leaves no sticky residue when it is sprayed
  • Kills lice and bedbugs on furniture and bedding and is effective for up to 4 weeks
  • Easy to use — simply spray affected bedbug and lice areas; not for use on humans
  • Nix is the number one pediatrician-recommended lice removal brand* * Based on Pediatrician Survey December 6, 2022
No. 8
Raid Bed Bug Foaming Spray, Kills Bed Bugs and Their Eggs, For Indoor Use, Non-Staining, Keeps Killing for Weeks, 16.5 oz
  • Kills bed bugs and their eggs on contact
  • Kills bed bugs on surfaces for up to 4 weeks
  • Foam expands into hard to reach indoor places, and is easy to see where you sprayed
  • Scientifically formulated to kill Pyrethroid-resistant Bed Bug strains
  • Money Back Guarantee
No. 9
HARRIS White Label Bed Bug Killer, Liquid Spray with Odorless and Non-Staining Extended Residual Kill Formula (32oz)
  • Kills Resistant Bed Bugs and Their Eggs - Kills even the toughest "pyrethroid resistant" bed bugs and eggs that have built up a resistant to traditional pesticides
  • Kills Quickly - Knocks down bed bugs fast when sprayed directly
  • EPA Registered - Approved for use in homes with people and pets by the Environmental Protection Agency (1021-2597-3). Always follow label directions
  • Long Residual - Continues to kill bed bugs for up to 16 weeks after initial application
  • Odorless Formula - Odorless and non-staining formula will not cause damage to fabrics when used according to label directions
No. 10
EcoVenger Bed Bug Killer (480ML) by EcoRaider−100% Kill Efficacy−Kills All Stages on Contact-14 Day Residual Protection− EcoFriendly & Non-Toxic Child & Pet Friendly
  • THE MOST EFFECTIVE BED BUG KILLER — Journal of economic entomology published university study confirmed that EcoVenger, previously as EcoRaider, is the only natural product that kills bed bugs with 100 percent efficacy.
  • PROVEN THROUGH USDA IR4 PHP PROGRAM — field tested by research entomologists for eradicating bed bug infestations in public housing buildings and recommend for sensitive environment
  • KILL ALL STAGES INCLUSIVE & EVEN RESISTANT BED BUGS — Kills bed bug adults and nymphs fast on contact with 100% efficacy, kills bed bugs that are resistant to traditional pesticides. Proven highest performance in eliminating bed bug eggs
  • EXTENDED DRY RESIDUAL PROTECTION — University study shows EcoRaider residual provides extended protection for two weeks on bed bugs even after dried
  • NON-TOXIC, SAFE AND ECO-FRIENDLY — certified USDA BioBased insecticide, dermatologically safe; child and pet friendly; safe to use directly on mattress and box springs.
No. 11
Raid Max Bed Bug Extended Protection, Kills Bed Bugs for 8 weeks on Laminated Woods and Surfaces, 22 Oz
  • Kills bed bugs & their eggs
  • Kills by contact
  • Keeps killing bed bugs for up to 8 weeks
  • Scientifically formulated to kill Parathyroid-resistant Bed Bug strains
No. 12
Bed Bug & Mite Extra Strength 3oz Travel Spray by Hygea Natural –TSA Approved - New Formula 66% Stronger- Stain & Scent Free Treatment – Natural Formula - Child & Pet Safe
  • TRAVEL SPRAY: Avoid bringing bed bugs home while traveling with a discreet bed bug treatment. Safely spray your luggage, hotel bed, and more. Activated on contact.
  • TSA-Approved Size: Protect yourself from bed bugs and other pests on the go. The convenient 3-oz size is TSA approved and fits into most handbags and luggage.
  • EXTRA-STRENGTH: Bed bugs may develop immunities to treatment over time. We made our signature formula 66% stronger to help you stay ready for anything.
  • LAB-TESTED: The Hygea Natural bed bug treatment spray was tested and proven for 100% efficacy by entomologist Louis Sorkin. They’re used by professionals every day.
  • STEP-BY-STEP GUIDE: We provide a 3-step bed bug extermination guide with every purchase. If you do not follow the steps in our guide, we cannot guarantee results.
No. 13
Rid Home Lice Bed Bug Dust Mite Spray for Home Treatment With Permethrin Kills Lice and Lice Eggs on Mattresses Furniture Car Interiors and Other Nonwashable Items Spray Can , 5 Ounce
  • Trusted Brand : RID is trusted by families for killing lice and lice eggs. This permethrin lice killing spray also kills bedbugs and dust mites.
  • KILLS LICE AND THEIR EGGS: RID Home Lice, Bed Bug & Dust Mite Spray kills lice and their eggs on mattresses, furniture, car interiors, and other non-washable items.
  • EFFECTIVE AGAINST BEDBUGS AND DUST MITES: RID Home Lice, Bed Bug & Dust Mite Spray is also effective at killing bedbugs and dust mites on non-washable items.
  • WHERE TO USE: RID Home Lice, Bed Bug & Dust Mite Spray kills lice & their eggs on mattresses, furniture, car interiors, and other non-washable items.
  • EASY TO USE: Just diffuse RID Home Lice, Bed Bug & Dust Mite Spray with permethrin for 3 seconds and allow to dry. Spray only on non-washable items such as mattresses, furniture, car interiors, and other items that cannot be laundered.
No. 14
Cosyworld Bed Bug Killer, Fast and Sure Kill with Extended Residual Protection Bug Spray, Organic Insect Killer & Natural Roach Spray & Non-Toxic Ant Killer, Child & Pet Friendly-22 oz
  • Size: 22 oz (650ml)
  • EFFECTIVE PROVEN INSECT KILLER. Bed Bug Spray for household and commercial use. Field tested and proven to eliminate bug infestations, including dust mites, spider mites, bird mites, stink bugs, cockroaches, silverfish, fleas, and ants.
  • SAFE AND NATURAL. EPA exempt.Made from non-toxic and the best natural ingredients that produce immediate results. Safe to use around children, pets, plant and cannabis. Will not stain bedding or furniture. Scent free with no harmful fumes that come from traditional pesticides.
  • GUARANTEED RESULTS. Effective for small and medium infestations. Kills adults, nymphs on contact, and eliminates eggs. Even kills pesticide resistant bugs and provides extended residual protection of up to 2 weeks after initial use.
  • 100% Green and made in the USA.
No. 15
Bed Bug Killer Spray by Premo Guard 24 oz – Fast Acting Bed Bug Treatment – Stain & Scent Free – Child & Pet Safe – Best Extended Protection – Natural & Non Toxic Formula
  • NATURAL. Made from natural ingredients. Use for entire home, farm, yard, travel, public housing, shelters, and other group home environments.
  • SAFE FOR FAMILY and PETS. You can use our bed bug spray with confidence and with peace of mind knowing that it is safe to use around the home, children and animals. Made 100% in the USA.
  • STAIN and SCENT FREE. When used according to label directions the spray will not stain bedding, pillows and other fabrics. Apply directly to sheets, mattress, pillow covers, pet bedding, carpets, furniture, curtains, etc. Scent free with no harmful fumes that come from traditional treatment products.
  • POWERFUL BUG KILLER. Kills bugs in all life stages (eggs, nymphs, adults). Kills bed bugs and mites effectively and fast on contact when sprayed directly onto bug.
  • EFFECTTIVE RESULTS. Our products are safe and are formulated using quality standards.
No. 16
Duuda 22oz Bed Bug Spray, Child & Pet Friendly Bed Bug Kill with Extended Residual Protection, Natural Dust Mite Spray, Non-Toxic Flea Killer
  • Size: 22 oz (650ml)
  • EFFECTIVE PROVEN INSECT KILLER. Poultry spay for household and commercial use. Field tested and proven to eliminate bug infestations, including dust mites, spider mites, bird mites, stink bugs, cockroaches, silverfish, fleas, and ants.
  • SAFE AND NATURAL. EPA exempt.Made from non-toxic and the best natural ingredients that produce immediate results. Safe to use around children, pets, plant and cannabis. Will not stain bedding or furniture. Scent free with no harmful fumes that come from traditional pesticides.
  • GUARANTEED RESULTS. Effective for small and medium infestations. Kills adults, nymphs on contact, and eliminates eggs. Even kills pesticide resistant bugs and provides extended residual protection of up to 2 weeks after initial use.
  • 100% Green and made in the USA.
SaleNo. 17
MGK 1852 Crossfire Concentrate 13oz Insecticide, for Bed Bugs, 13 oz, Clear
  • CrossFire is formulated to kill pyrethroid-resistant bed bug strains at all life stages, including eggs.
  • Quick knockdown and kill, Residual control begins working within minutes of exposure
  • Approved for direct application onto mattresses
  • Easy to mix – one 13 oz bottle makes 1 gallon of finished product
No. 18
Ecologic Bed Bug Killer 64 Ounces, Ready-To-Use Spray, Kills Pyrethroid-Resistant Bed Bugs And Eggs
  • KILLS BED BUGS BY CONTACT: Ready-to-use spray kills bed bugs by contact, including pyrethroid-resistant bed bug and bed bug eggs, along with fleas.
  • TREAT CRACKS AND CREVICES: Apply as a spot treatment to cracks and crevices around baseboards, floorboards, bedboards, carpet edges, walls and more.
  • TREAT MATTRESSES: Use on mattresses, box springs, bed frames and luggage as listed.
  • ACTIVE INGREDIENTS: Formulated with lemongrass oil and cornmint oil.
  • SAFE AROUND KIDS AND PETS: When used and stored as directed.
No. 19
Bed Bug Patrol Natural Bed Bug Killer Spray, Child & Pet Friendly, Non-Toxic, Suitable for Home, Office, Vehicles, Mattresses & Furniture, 1 Gallon - 24oz (1 Pack) - Bug Spray Bed Bug Spray - Bug Bye
3,730 Consomer Reviews
Bed Bug Patrol Natural Bed Bug Killer Spray, Child & Pet Friendly, Non-Toxic, Suitable for Home, Office, Vehicles, Mattresses & Furniture, 1 Gallon - 24oz (1 Pack) - Bug Spray Bed Bug Spray - Bug Bye
  • PROVEN TO BE EFFECTIVE! — The Journal of Economic Entomology published an independent study by Rutgers University Entomology Department, which confirmed that Bed Bug Patrol is "The Most Effective Essential Oil-Based Pesticide" on the market. Bed Bug Patrol's 100% natural, proprietary formula eradicates bedbugs in every life-cycle, from egg to nymph and pesticide-resistant mutating adults. It is helping to prevent future outbreaks of bed bugs and stopping mutation in its tracks.
  • KILLS ALL STAGES OF BED BUGS, EVEN PESTICIDE RESISTANT ONES: — Kills bed bug adults and nymphs fast through all life cycles with independent University and lab tested 100% efficacy. Our product effectively stops the hardest-to-kill bed bugs resistant to traditional chemical pesticides. Proven excellent performance against the toughest bed bugs. Guaranteed.
  • OUR PRODUCT IS 100% PLANT-BASED & NON-TOXIC: — Bed Bug Patrol is all-natural Made in the USA, using non-toxic ingredients (including natural Peppermint Oil and Clove Oil). Child and Pet Safe - No more worries about toxic fumes or dangerous chemicals coming in contact with you, your family, and your pets. Our product is so safe that it's on the EPA's non-pesticide list of natural ingredients that are very effective at stopping bed bug infestations in their tracks!
  • BE ASSURED OUR PRODUCT IS FAMILY, CHILD & PET SAFE — You Will Have No More Worries about Toxic Fumes or Dangerous Chemicals Coming in Contact With You and Your Family or Pets. Rest Assured, You Are Buying an EPA Exempt 25b Minimum Risk Pesticide Safe and Effective.
  • UNIVERSITY & LAB TESTED — Rutgers University and Snell Scientifics, Inc. Each Conducted Independent Treatment Tests of Bed Bug Patrol Natural Bug Killer. Bed Bug Patrol Has an Impressive Mortality Rate of 83%, Killing Bed Bugs Within 30 Minutes After Application and 98% Within the First Four Hours. Upon Completion of the Study, Bed Bug Patrol Bed Bug Killer Demonstrated a 100% Kill Rate on Bed Bugs.
  • STAIN-FREE* — Our One-Of-A-Kind Formula Can Be Used On Any Water-Safe Surface, Including Upholstery, Mattresses, Bed Linens, Clothing, Walls, Etc. Spray a Light Mist and Watch as Our Product Leaves Nothing But a Pleasant Peppermint Scent Along With Destroyed Bed Bugs. *As With All New Products, Please Do A Small Discreet Patch Test On Any Fabric/Material Before First Use.
  • DOWNLOAD OUR FREE STEP-BY-STEP EBOOK: — Scan Our QR Code on the Product Card Shipped with the Product to Receive Your Free Digital PDF eBook on How to Get Rid of Bed Bugs Quickly. This eBook Gives You an In-Depth Look About Bed Bugs and How to Effectively Win Your Bed Bug Battle Rapidly.
  • WE STAND BEHIND OUR PRODUCTS: — We Stand Behind Our Bed Bug Killer Products.. If, For Any Reason You Are Not Completely Satisfied, Please Reach Out to Us Directly So We Can Assist You With Expediting That Refund Easily.
No. 20
Hot Shot Ready-to-Use Bed Bug Killer Spray, Kills Bed Bugs and Bug Eggs Indoors, Kills Fleas and Dust Mites, Non-Staining, 1 Gallon
7,668 Consomer Reviews
Hot Shot Ready-to-Use Bed Bug Killer Spray, Kills Bed Bugs and Bug Eggs Indoors, Kills Fleas and Dust Mites, Non-Staining, 1 Gallon
  • Bed bug treatment: Hot Shot bed bug Killer with egg kill kills bed bugs and bed bug eggs, adult and pre-adult (larvae) fleas and Dust mites
  • Use indoors: spot treat mattress tufts, folds, vent holes, buttons, creases, indentations and seams – do not use on pets
  • Water-based formula: this non-staining formula leaves no odor
  • Application: spray intended use areas until damp, but do not saturate – inspect the area and apply every two weeks while bed bugs are present
  • Treat bed bugs as part of a cycle: for Best results, use this product as part of a comprehensive bed bug treatment plan — treating bed bugs as part of a cycle is key to gaining control

How to choose a good bed bug spray for mattress

Does the idea of finding a fantastic bed bug spray for mattress make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in bed bug spray for mattress. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top bed bug spray for mattress products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top bed bug spray for mattress on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top bed bug spray for mattress brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top bed bug spray for mattress based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the bed bug spray for mattress were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good bed bug spray for mattress, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your bed bug spray for mattress.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting bed bug spray for mattress for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our bed bug spray for mattress. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what bed bug spray for mattress should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on bed bug spray for mattress.