Are you trying to find cold sore medicines among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!
We investigated and evaluated a number of the top-selling cold sore medicines on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 15 hours of research and did 40 cold sore medicines tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!
An overview of our top picks
Table of contents
The best cold sore medicines you can buy today
- One tube of Abreva Cold Sore Rapid Pain Relief, 3 grams.
- Shortens duration of tingling, pain, burning and itching
- Easy applicable tube form for on-the-go use
- When you feel pain and burning from the cold sore or blister, Abreva has you covered with Abreva Rapid Pain Relief gel
- It delivers quick, targeted relief from the first application
- Number 1 Cold Sore Brand: Two 0.07 oz tubes of Abreva 10 Percent Docosanol Cold Sore Treatment
- Can Heal in 2.5 Days: Fever blister cream contains 10 percent docosanol to shorten the duration of cold sore symptoms (1)
- Nothing Heals Fever Blisters Faster: 10 percent docosanol cream penetrates deep into skin to tackle cold sores at their source (1, 2, 3)
- Lip Cream Clinically Proven to Shorten Duration of Symptoms: Cold sore product shortens duration of tingling, pain, burning and itching associated with cold sores (1)
- Portable Cold Sore Cream: Packaged in a convenient tube for on the go cold sore treatment
- Number 1 Dermatologist Recommended Cold Sore Treatment: Abreva Cream is a nonprescription cold sore medicine that shortens healing time (1)
- HSA and FSA eligible product
- DON'T LET A COLD SORE RUIN YOUR MOMENT!: Take daily (for best results) or start taking a few weeks before an important date, presentation, travel, or any other stressful event that you have experienced cold sores in the past.
- POWERFUL INGREDIENTS: Combination of potent immune supporting nutrients including zinc, selenium, vitamin C, L lysine and more. All made and manufactured in the U.S.A
- IMMUNE SYSTEM BOOST: Cold sore shield's cold sore treatment works with the body's immune system for around the clock daily support.*
- DAILY SUPPLEMENT: Take daily, or just weeks before a stressful event, important date, travel etc where you have experienced outbreaks in the past.
- BUY WITH CONFIDENCE: Buy our product worry free! If our product does not meet your expectations, simply return it! Manufactured in the U.SA
- Specially formulated for cold sores/fever blisters
- Instantly relieves pain & itch
- Helps prevent infection to promote healing
- For adults and children 2 years and over
- Store at room temperature
- Treats cold sores/fever blisters
- For pain, tingling, itching & burning
- Soothing and non-irritating
- Patented Viracea formula
- TOUCH- FREE APPLICATOR: Unique application system is designed so you don’t have to touch your cold sore or fever blister with your fingers. Use the applicator to apply our treatment right where you need it most.
- RELIEVES PAIN* & ITCHING: Orajel Cold Sore Treatment numbs the area of your cold sore to help reduce pain and itching. *For temporary topical pain relief.
- DISINFECTS: One of a kind formula is designed to clean the area of the cold sore, to disinfect, as well as provide immediate, targeted pain relief.
- NVISIBLE & QUICK DRYING: Our formula is clear, leaving no residue behind, and a quick drying treatment for your cold sore.
- From the #1 Oral Pain Reliever Brand for Adults.
- Instant Pain Relief
- Skin Protectant
- Maximum strength benzocaine
- Moisturelock cream
- Helps mask redness
- One tube of cream
- Relieves itching and burning
- Portable tube
- Temporary relief
- Easy to apply
- Triple Action spot treatment instantly numbs cold sore and fever blister pain & itch, protects against infection, and helps prevent cracking
- Maximum strength lidocaine targets and numbs cold sore pain & itch right at the source and starts working on contact
- A soothing skin protectant helps prevent painful cracking and re-opening while keeping the cold sore moisturized
- Maximum strength antiseptic helps keep the cold sore from getting infected
- No burning, No irritation, Goes on clear
- Number 1 Cold Sore Brand: One 0.07 oz pump bottle of Abreva 10% Docosanol Cold Sore Treatment
- Can Heal in 2.5 Days: Fever blister smooth, white cream contains 10% docosanol to shorten the duration of cold sore symptoms (1) by blocking the virus from infecting healthy cells
- Nothing Heals Fever Blisters Faster: Scientifically-proven medicine to shorten cold sore healing time
- Lip Cream Clinically Proven to Shorten Duration of Symptoms: Cold sore product shortens duration of tingling, pain, burning and itching associated with cold sores (1)
- Portable Cold Sore Cream: Packaged in a convenient pump bottle for on the go cold sore treatment
- Number 1 Dermatologist Recommended Cold Sore Treatment: Abreva Cream is a nonprescription cold sore medicine that shortens healing time (1)
- HSA and FSA eligible product
- Docosanol Cream 10% – Treats cold sores/fever blisters
- Treats Cold Sores / Fever Blisters on the Face or Lips
- Shortens Healing Time and duration of Symptoms
- HALVE YOUR HEALING TIME - Cut cold sore healing time by 50% with the power of L-Lysine, a scientifically researched amino acid that inhibits arginine activity, nourishes skin and accelerates recovery.
- FAST-ACTING PAIN & ITCH RELIEF - Experience rapid relief from cold sore pain, burning, and itching discomfort with the cooling effect of Menthol plus 14 herbal ingredients to soothe and nourish your skin.
- HERBAL LIP TREATMENT - Harness the power of our nutrient-rich formula with Calendula, Vitamin E, and Propolis, providing deep moisturization and skin-nourishing properties for overall lip health.
- DISCREET COMFORT - Invisible balm can be worn under lipstick or gloss without worry, doesn't burn upon application, and offers relief from tingling, itching, burning, and other discomforts associated with cold sores.
- ROUND OUT YOUR LIP CARE ROUTINE - For optimal results use Lysine+ Ointment with our Super Lysine Immune Support Tablets and Lip Clear Invisible Cold Sore Patch to calm cold sores and promote faster healing.
- HELP FOR RECURRING COLD SORES - Clear Lip and Skin Health is a specially formulated probiotic blend with key ingredients like lysine and vitamin C that helps to prevent the overproduction of arginine in the body. Arginine is known as a common trigger for lip and mouth blisters, as well as other issues.
- SUPPORTS SKIN & LIP HEALTH - Did you know that cold sores and blisters around your mouth can be the result of a bacterial imbalance in your gut? Our scientifically researched probiotic strains are paired with a prebiotic blend with lysine, formulated to balance out the bacteria most often responsible for these outbreaks.
- SCIENTIFICALLY SELECTED STRAINS FOR SKIN & GUT MICROBIOME BALANCE - Clear Lip and Skin Health promotes healthy, clear lips and skin and GI tract health. Ease bloating and balance digestion to help maintain regularity, while improving your skin health from the inside out.
- POWERFUL INGREDIENTS TO FIGHT OUTBREAKS - Our powerful formula contains key ingredients like vitamin C and lysine which are designed to improve immune function, and balance digestion. Balance the gut and minimize the production of the amino acid most associated with mouth and lip blisters.
- CONTINUES TO IMPROVE - Clear Wellness 360 stands for full transparency with proven formulas using ingredients in clinically studied doses. The best results come with consistent daily use over months or longer. Our Vegan, Non-GMO formulas are 3rd party tested for purity, potency, and safety. No artificial flavors, fillers, or colors.
- MONEY-BACK GUARANTEE: If you have any challenges using Clear Probiotics Supplements, reach out anytime for help from our healthcare experts. We'll respond ASAP! If you're not totally satisfied, we will refund you in full.
- DOCOSANOL CREAM 10% – Treats cold sores/fever blisters on face or lips. Shortens the healing time and duration of cold sore symptoms
- APPLY AT FIRST SIGNS - Tackle cold sores head on. Use at first signs of symptoms for a faster recovery.
- SHORTEN HEALING TIME – This non-prescription cold sore medicine can be used five times a day until the cold sore is healed.
- HELP ON THE GO – Convenient sized packaging means you can treat cold sores on the go.
- Compare to the Active Ingredient in leading national brand
- FAST HEALING ultra-thin Hydrocolloid Gel provides a moist environment to help: relieve pain, reduce the blistering and prevent scabbing.
- Unbeatable Sale is a privately held direct marketing retailer
- Our management shares more than 30 years of experience in direct marketing and consumer goods industries
- Our mission is "to meet consumer demand in a demanding world"
- The package dimension of the product is: 3"L x5"W x5"H
- HERPECIN L LIP BALM: Herpecin L Everyday Protection helps relieve and protect against cold sores, fever blisters, and chapped lips. It's formulated with lysine, Vitamins C, B6, and E, lemon balm and added SPF 30 protection.
- PROTECT AND TREAT YOUR LIPS: Treat your lips to soothing relief from dryness, sun blisters, and cold sores with Herpecin L. Find real relief from herpes related cold sores from real medicine, and protect your lips with Herpecin L lip balm with SPF 30.
- REAL RELIEF FROM REAL MEDICINE: Herpecin L soothes, moisturizes & creates a SPF 30 barrier to protect your lips against the sun's harmful UV rays. It does more for a cold sore.
- SPF 30 PROTECTION: UV rays can increase your risk of sun cancer, chapped lips, early skin aging & damaged skin can promote the development of cold sores. Herpecin L lip balm can help prevent sunburn.
- HERPECIN L FOR COLD SORES: Uniquely formulated with dimethicone & lysine, Herpecin helps relieve & protect painful cracking of lips & promotes healing of cold sores without numbing or drying.
- FAST HEALING: Hydrocolloid patch with added lysine, zinc and calendula provides a moist environment to help heal reduce the blistering and prevent scabbing.
- DISCREET LIP BANDAGE: Treat your sores discreetly with Acculip Lip Bandages. Skip messy creams and help healing with a patch that does more for less.
- SOOTHES AND PROTECTS: Cover and heal cold sores with Acculip Lip Patches to help shield cold sores from the environment.
- REDUCES APPEARANCE: They also help to minimize the look of cold sores in addition to hiding and healing them, so you can look and feel your best - you can even wear the patch under makeup.
- COLD SORE TREATMENT: Treatment includes lysine, zinc and calendula to hydrate and heal cold sore and fever blisters for relief and protection
- COUGH COLD AND FLU MEDICINES FOR ADULTS: This combo pack of Maximum Strength Mucinex Fast-Max Cold & Flu and Nightshift Severe Cold & Flu provides powerful multi-symptom cold and flu relief for your worst cold and flu symptoms
- SORE THROAT RELIEF: Both liquids contain Acetaminophen, which helps reduce fever and relieves sore throat, headache, and body pain
- COUGH MEDICINE FOR ADULTS: Both liquids contain Dextromethorphan HBr, which helps suppress and quiet cough
- CHEST CONGESTION RELIEF: Daytime liquid contains Guaifenesin, an expectorant, which helps relieve chest congestion and thins and loosens mucus
- NASAL DECONGESTANT: Both liquids contain Phenylephrine HCl, a nasal decongestant, which helps relieve stuffy nose, sinus pressure, & nasal congestion
- NIGHTTIME COLD AND FLU MEDICINE FOR ADULTS: Nighttime liquid contains Triprolidine HCl, an antihistamine, which helps relieve runny nose & sneezing
- TRUSTED BRAND: Mucinex is the #1 Cough & Cold Brand Doctor's Trust(1) and is also the #1 Pharmacist Recommended OTC Expectorant(2); Get the brand that doctors trust and recommend
- USAGE: Use as directed; For ages 12+ years
- FSA & HSA Eligible: Save Up to 30%; Cover out-of-pocket expenses with pre-tax dollars (Product eligibility may vary by plan. Check with your benefits administrator to determine which expenses are eligible before you shop)
- (1)IQVIA using ProVoice Survey, August 2023; (2)U.S. News & World Report/Pharmacy Times 2023-2024
- MULTIPURPOSE MOUTH ULCER RELIEF: OraSwift Mint Lozenges are a canker sore medicine designed to help speed up the healing process taking place inside your mouth. Most notably, Oraswift can be used to help speed up healing when dealing with painful canker sores, mouth ulcers, cuts, abrasions, sensitive gums, dry mouth, stomatitis and gingivitis. By relying heavily on active Zinc, Orawsift is a unique all natural ulcers medicine and mouth ulcers relief.
- SHORTENS HEALING TIME: The unique and novel active zinc in our all-natural canker sore relief initiates the healing process. L-Carnosine delivers the ingredients to the affected area, and Xylitol and Sorbitol prevent Dry Mouth and Tooth Decay. Our proven remedy supports overall mouth hygiene and helps prevent dry mouth and tooth decay, and are a strong alternative to alum powder for canker sores.
- NATURAL AND SAFE INGREDIENTS: We care about your health, and that's why our mouth ulcer relief lozenges are 100% natural. The ingredients are patented and naturally derived to preserve their potency. Our lozenges are backed by multiple clinical trials and proven as an effective solution to most oral conditions.
- NO MORE RECURRING MOUTH ULCERS: Our canker sore remedy addresses the issue at the cause and helps eliminate chances of future oral conditions by creating a healthy mucosal lining in the mouth.
- EASY TO USE: Our lozenges function similarly to a cold sore patch, canker sore patch, mouth sore gel, or canker covers. Simply apply the lozenge to the painful area twice daily to help accelerate healing time caused by mouth sores.
How to choose a good cold sore medicines
Does the idea of finding a fantastic cold sore medicines make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!
Your presence here indicates that you are interested in cold sore medicines. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top cold sore medicines products available right now. You might be wondering how we came up with the list. How was this buying guide developed?
First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top cold sore medicines on the market right now!
The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:
Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top cold sore medicines brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.
Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top cold sore medicines based on those.
Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.
Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.
Customer ratings: Would it be accurate to suggest that the cold sore medicines were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.
Customer Reviews: Like ratings, provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.
Seller Rank: This is very intriguing! Not only do you need a good cold sore medicines, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.
Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your cold sore medicines.
Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting cold sore medicines for months and years to come.
Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.
Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.
These are the standards by which we selected our cold sore medicines. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.
Why should you believe us?
There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what cold sore medicines should you purchase in 2022?
This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on cold sore medicines.
