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The 8 Best digestive enzyme supplements of 2024

Are you trying to find digestive enzyme supplements among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling digestive enzyme supplements on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 22 hours of research and did 20 digestive enzyme supplements tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best digestive enzyme supplements you can buy today

No. 1
THORNE Advanced Digestive Enzymes (Formerly Bio-Gest) - Blend of Digestive Enzymes to Aid Digestion - Gut Health Support with Pepsin, Ox Bile, Pancreatin - 180 Capsules - 90 Servings
  • Support for Indigestion: Benefits individuals who have occasional indigestion, food sensitivities, gallbladder removal, or who have overused antacids*
  • Comprehensive Formula: A blend of hydrochloric acid, pepsin, pancreatin, and ox bile
  • Promotes Digestion: Can help ease digestive discomfort that may occur after a meal heavy in fat or red meat, when enjoying foods that cause extra gas and bloating, or when partaking in an occasional overindulgence
  • Promotes Nutrient Absorption: Benefits absorption of vitamins, minerals, and other nutrients*
  • Trusted: Thorne is trusted by 45,000 health-care professionals and 100+ pro teams and U.S. Olympic teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content
SaleNo. 2
Sports Research Digestive Enzymes with Probiotics & Ginger - Plant Based for Dairy, Protein, Sugar & Carbs - Non-GMO Verified & Vegan Certified (90 Veggie Capsules)
  • COMPLETE GUT WELLNESS: With 15 enzymes plus probiotics and ginger— these veggie capsules are here to promote better nutrient absorption, encourage proper digestion, and help promote stomach regularity*
  • HELP EASE STOMACH DIGESTION: Digestive Enzymes from Sports Research is specially formulated to help you digest proteins, fats, fruits, vegetable fiber, dairy products, and carbohydrates, resulting in better nutrient absorption and less digestive discomfort*
  • BEAT THE BLOAT: Replenishes enzymes that may decline with age. Our plant-based digestive enzymes with probiotics and ginger work synergistically to help tackle hard-to-digest foods and stomach bloating*
  • QUALITY ASSURED: We hold all of our supplements to a higher standard. Rest assured that your digestive enzymes capsules are manufactured in a cGMP-compliant USA facility and third-party tested for quality. Our digestive enzymes capsules are Non-GMO Project Verified, Vegan Certified, and free of gluten, soy, and unwanted fillers
  • THE SPORTS RESEARCH DIFFERENCE: Founded in Southern California in 1980, Sports Research is a family-owned business born from a passion for fitness and wellness. Our goal is to embrace the sport of life through research-backed products created for every body—inside and out (Please remove product label before recycling bottle)
SaleNo. 3
Enzymedica Digest Gold + ATPro, Maximum Strength, Fast-Acting, Helps Digest Large Meals, Prevents Bloating and Gas, 90 Count (FFP)
2,805 Consomer Reviews
Enzymedica Digest Gold + ATPro, Maximum Strength, Fast-Acting, Helps Digest Large Meals, Prevents Bloating and Gas, 90 Count (FFP)
  • For Food Lovers: Savor your favorite dishes worry-free; Our full-strength, bloat-busting digestive enzyme blend helps break down large meals faster, easing bloating and occasional indigestion for care-free indulgence*
  • ATPro Blend: Beat the post-meal blues and feel fueled with energy to power through your day; This unique formula features ATPro, a proprietary blend of ATP, Magnesium Citrate, Phytase and CoQ10 that helps fuel your body's cells*
  • Effective All the Way Through: Our proprietary Thera-blend enzymes are formulated for optimal activity throughout the digestive system's varying pH levels, providing faster relief and maximum digestive support*
  • Dosage: Just 1 capsule daily breaks down up to 34g fat, 16g protein and 86g carbs; Contains no gluten, milk, casein, soy, egg, artificial colors, flavors, or GMOs; Vegan, Kosher and Clean Label Project Certified
  • Making a Difference: Enzymedica products harness the power of the finest natural ingredients for maximum effectiveness; We create quality products without compromise while championing initiatives that support the well-being of people and our planet
No. 4
Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption – Organic Digest+ - Vegan, Gluten-Free, Non-GMO, Tropical Fruit Flavor, 90 Chewables
  • BREAK IT DOWN: Organic Digest offers 29 Certified Organic fruits and vegetables plus a select blend of 13 powerful digestive enzymes including amylase, bromelain, and lactase to help with digestion after meals
  • MADE FROM WHOLE FOODS: Dr. Perlmutter formulated Digest to be a full spectrum plant-based enzyme formula to aid the digestion of proteins, fats, and carbs; We’ve also included prebiotic fiber from Organic Acacia to support the good bacteria in your gut
  • BACKED BY SCIENCE: Our Dr. Formulated Organic Digest is the first-ever Certified Organic and Non-GMO digestive enzyme formula that is made from real food and is delivered using Clean Tablet Technology to ensure optimal nutrient absorption
  • CONVENIENCE IN MIND: Transport to the tropics after every last bite; Enjoy the benefits of Organic Digest in a tropical flavored, shelf stable tablet thats size makes it easy to take on the go; Adults chew 1 tablet after each meal or snack
  • EXPERTLY FORMULATED: Our digestive supplement is proudly Dr. Formulated by David Perlmutter, MD and Third-Party Certified Non-GMO, Gluten-Free, Vegan and Carbon Neutral; Made in the USA with no dairy, soy, gluten, peanuts or tree nuts
SaleNo. 5
NOW Supplements, Optimal Digestive System, Full Spectrum Enzymes, 90 Veg Capsules
1,730 Consomer Reviews
NOW Supplements, Optimal Digestive System, Full Spectrum Enzymes, 90 Veg Capsules
  • FULL SPECTRUM ENZYMES: Take 2 NOW Optimal Digestive System capsules with or before each meal for maximum food utilization.*
  • Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
  • HELPS WITH BEAN AND CABBAGE DIGESTION*: Offers a blend of enzymes that will aid in the digestion of most foods, including beans and cruciferous vegetables.*
  • CERTIFICATIONS/CLASSIFICATIONS: Quality GMP Assured, Vegan/Vegetarian, Soy Free, Keto Friendly
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
  • Packaged in the USA by a family owned and operated company since 1968
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
No. 6
designs for health Digestzymes - Digestive Enzymes + Betaine Hydrochloride for Gas & Bloating Relief - Pepsin, Ox Bile, Lactase Enzyme & Lipase Enzymes for Digestion (90 Capsules)
  • Support Food Breakdown + Nutrient Absorption - This digestive enzyme supplement is a multi enzyme blend of a proprietary blend of digestive enzymes alongside hcl betaine with pepsin to support gut health and optimal digestion of proteins, fats, and carbohydrates.*
  • Occasional Gas or Bloating After Meals? Enzymes for digestion may be helpful for those experiencing occasional gas after eating, constipation, or a feeling of fullness after eating only a small quantity of food.* The use of Digestzyme before meals may offer occasional mild bloating relief. Take one digestion supplement capsule before meals to support digestive gut health.*
  • Pancreatic Enzymes + Betaine HCl - Protease DPP IV aids in the breakdown of casomorphin (from casein protein) and gluteomorphin (from gluten). Lactase enzyme helps break down the dairy sugar lactose, while lipase support fats and fat-soluble vitamins. The betaine hydrochloride supplement supports protein digestion and nutrient absorption.*
  • Why Add Bile Salts to Your Digestive Enzyme Blend? Ox bile provides bile acids, which are key to the digestion of fat and fat-soluble vitamins. Ox bile digestive enzymes formulas can offer further support for malabsorption and maldigestion, including fats.*
  • Over 50,000 Doctors Agree - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. DFH pancreatic enzyme supplements and gut health supplements for women and men are manufactured in a GMP registered facility in the USA from US and globally sourced ingredients.
SaleNo. 7
Carlyle Digestive Enzymes | with Probiotics & Prebiotics | 180 Capsules | Non-GMO and Gluten Free Supplement
  • DIGESTIVE ENZYMES: Get full spectrum digestive support from a range of enzymes plus probiotics & prebiotics*
  • SUPER CONVENIENT: Simply take two capsules before or after meals for maximum support
  • ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living
  • CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
  • FREE OF: Gluten, Wheat, Soy, Artificial Color, Artificial Flavor, Preservatives & Non-GMO
No. 9
Ultra Digestive Enzymes Capsules | Up to 2 Month Supply | Enzyme Supplement for Gut Health Support | Digestion & Immune Support with Amylase | Lipase & Lactase | Vegan | Gluten Free | 60 Count
  • Ultra Digestive Food Enzymes: Enhance Digestion With This Ultra Digestive Food Enzyme Blend. This supplement is formulated to enable digestion, especially in those with digestive issues, amplifying nutrient absorption while reducing bloating, gas and abdominal pain.
  • Multiple Benefits: This extra strength blend of enzymes are formulated to help digest proteins, carbohydrates, fiber, fat, and lactose. They even include enzymes to help relieve occasional gas and bloating, too! This supplement was specifically formulated to support digestion, as well as reduce occasional bloating, gas, and abdominal pain.
  • Vegan Formula: We include more of every enzyme that can help you feel your best: Protease, Amylase, Glucoamylase, Diastase, Invertase, Pectinase, Cellulase, Hemicellulase, Xylanase, Lipase, Lactase, Alpha-Galactosidase, and Beta-Glucanase. Our enzymes also include Vitamin B1, B6, B12, Calcium, Magnesium, Manganese, Amla, and Phytase. Other Ingredients: Hypromellose, Maltodextrin, Calcium Phosphate.
  • Easy Efficient Absorption: Formulated for men and women. Each bottle contains 60 capsules, with a serving size of 1 capsule, and will last 1-2 months. Adults take 1 capsule prior to each meal or as recommended by physician or healthcare professional. Keep out of reach of children in case of accidental overdose or choking. Store in a cool, dry place.
  • For Most Lifestyles: MaryRuth's Ultra Digestive Food Enzymes are Non-GMO & Vegan. Dairy Free, Nut Free, Gluten & Wheat Free, Soy Free, Nightshade Free, Sugar Free. This product CONTAINS Maltodextrin: which is corn-derived.
No. 10
HUM Flatter Me Supplement for Daily Bloating - 18 Full Spectrum Digestive Enzymes to Support Food Breakdown - Ginger, Fennel Seed & Peppermint for Nutrient Absorption (30-Day Supply)
  • BLOATED BELLY RELIEF - Flatter Me is a blend of full-spectrum enzymes for digestion and bloating relief for women.*
  • WHAT'S INSIDE - Flatter Me's unique no bloat formula contains 18 full-spectrum digestive enzymes plus ginger, peppermint leaf, and fennel seed, avoiding the need for individual products like peppermint capsules for bloating and more.*
  • DIGESTION SUPPORT - This anti bloat formula includes ginger and peppermint leaf to support digestive health. Fennel seed helps soothe digestion and support nutrient absorption. A potent multi enzyme blend helps break down food for gas and bloating relief.*
  • HOW TO TAKE - Take 1 capsule, twice daily, before your two main meals. This women's supplement is best when taken before eating to help reduce bloating, but you can take it during or shortly after your meal. Flatter Me is compatible with other HUM products for digestion, gut health and more.*
  • CLINICALLY TESTED - After only one use of Flatter Me debloat pills, 80% of users felt relief.* Additionally, users also felt as much as 2 inches less bloating.* *Based on a placebo-controlled crossover clinical study of 19 participants who took two identical test meals, one with Flatter Me and one with a placebo. Each participant was assessed by waist circumference measurements.

How to choose a good digestive enzyme supplements

Does the idea of finding a fantastic digestive enzyme supplements make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in digestive enzyme supplements. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top digestive enzyme supplements products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top digestive enzyme supplements on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top digestive enzyme supplements brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top digestive enzyme supplements based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the digestive enzyme supplements were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good digestive enzyme supplements, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your digestive enzyme supplements.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting digestive enzyme supplements for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our digestive enzyme supplements. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what digestive enzyme supplements should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on digestive enzyme supplements.