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The 8 Best enzyme for drains of 2025

Are you trying to find enzyme for drains among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling enzyme for drains on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 18 hours of research and did 78 enzyme for drains tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best enzyme for drains you can buy today

No. 1
AmazonCommercial Multi-Purpose Enzyme Cleaner, Mint, 1 gallon, 128 fl oz (Pack of 1)
  • 1 gallon bottle of multi-purpose enzyme cleaning solution for a wide variety of surfaces and environments – use on carpets, furniture, hardwood, tile, drains, liter boxes, garbage cans, RVs and more
  • Breaks up complex organic proteins, pet smells and stains, grease, oils, and more for effective results
  • Powerful enzymatic formula removes stains and odors deep in the carpet
  • Attack grease, fats and other organic matter that cause slow drains and unpleasant odors - not effective on bathroom clogs due to hair like a hazardous caustic drain opener
  • Non-corrosive, non-flammable, non-acidic, and non-caustic with a fresh mint scent
SaleNo. 2
Green Gobbler Enzyme Drain Cleaner | Controls Foul Odors & Breaks Down Grease, Paper, Fat & Oil in Sewer Lines, Septic Tanks & Grease Traps | 1 Gallon
  • ENZYME ENHANCED FORMULA: Green Gobbler Enzymatic Drain & Grease Trap Cleaner uses an enzyme enhanced formula to clear buildup and remove odors in grease traps, septic tanks and similar plumbing systems. It helps digests oils, fats, grease, sludge and other food waste within hours of application. This bottle uses anti-glug technology to help reduce splashing and provides up to eight treatments.
  • SAFE FOR PIPES: Green Gobbler helps maintain drain lines, septic tanks, grease traps and grease interceptors. Our enzyme enhanced formula is an excellent alternative to sodium hydroxide and other caustic chemicals.
  • IMPROVE GREASE TRAP EFFICIENCY: Green Gobbler increases the efficacy of grease traps by allowing enzymes & bacteria to work more efficiently to promote the separation of water and grease, helping your trap run more smoothly.
  • KEEP SEPTIC TANKS HEALTHY: Green Gobbler helps prompt the biological breakdown of foul odors and organic material inside demanding environments such as drains, pipes and septic tanks.
  • GREEN GOBBLER GUARANTEE: Green Gobbler cares about its customers. We take pride in developing innovative & effective products for your home or business. If for any reason you are unsatisfied, please contact us. We offer a money-back guarantee within 30 days of purchase.
No. 3
Zep Drain Defense Enzymatic Drain Cleaner Powder 18 Ounces (Case of 2) ZDC16 - Safe for Pipes and Septic Systems
  • Helps prevent clogs in sinks, toilets and showers
  • ENZYME BASED FORMULA: Breaks down drain-clogging elements. Use monthly to prevent future clogs from happening
  • SAFE FOR: PVC and most other septic systems
  • Certified, biodegradable formula, breaks down into carbon dioxide, minerals and water
  • BREAKS DOWN: Into CO2, minerals and water
No. 4
Bio-Clean Drain Septic 2# Can Cleans Drains- Septic Tanks - Grease Traps All Natural and 100% Guaranteed No Caustic Chemicals! Removes fats oil and grease, completely cleans your system.
  • LISTING IS FOR 1 TWO POUND CANISTER
  • Special combination of natural microbes and enzymes that DIGESTS dead organic waste found in your plumbing system
  • Eliminates costly backups. Up to 100 Drain Treatments.
  • Environmentally friendly and safe.
  • Multi Purpose. Kitchen sinks, showers, bath tubs, garbage disposals, septic tanks & fields, cat litter pans, motor homes and much more!
No. 5
Natural Elements Enzyme Drain Cleaner | Digest Grease, Fats, and Paper Buildup in Drains, Septic Tanks, Grease Traps, Pipes (1 Gallon)
  • 🪠 ADVANCED ENZYME FORMULA- Attacks Fat, organic waste, oil, paper, hair, and grease. Use in kitchen and bathroom sinks, shower and floor drains, toilets, septic systems, commercial sinks and grease trap systems. Safe for home use or commercial applications, eco-friendly and biodegradable formula.
  • 🪠 HIGHLY EFFECTIVE ODOR REDUCTION- Works within Hours of Application- Excellent for garbage disposals and odor producing floor drains.
  • 🪠 OPEN DRAINS, REDUCE BUILDUP- This product eliminates the grease, hair, soap scum, food, and organic waste found in your pipes, allowing them to flow freely.
  • 🪠 SAFE FOR ALL PIPES and PLUMBING FIXTURES- Does not produce heat, boiling, fumes or corrosion that occur with drain products with harmful chemicals
  • 🪠 EXCELLENT MAINTENANCE PRODUCT- Reduces the need for future rotary drain cleaning, septic pump outs, reduces grease trap pumpouts, and maintenance. This product can be highly effective for problem plumbing, grease traps, septic systems, and drain fields, reducing buildup and allowing the system to go back to its original working order.
  • Please note, this is not to be expected as an instant clog remover, but as a maintenance product opening and maintaining pipes and systems over time. Progress can be seen after the first treatment, the system will need maintenance treatments for the product and enzymes to reach their maximum effectiveness.
No. 6
SANI 360° Sani Sticks Drain Cleaner and Deodorizer, Enzyme Pipe Cleaners, Eliminate Odors, Prevent Clogged Drains, Safe for Sinks, Bathtub Drains, Septic Tanks, 24 Count, Forest Snow
  • POWERFUL DRAIN-CLEANER, ODOR-ELIMINATOR STICKS: Sani Sticks are formulated with a powerful blend of enzymes to help prevent clogged drains and eliminate embarrassing odors in kitchen, bathroom, and laundry utility sinks. Sani Sticks are safe to use on all drains, plumbing, and septic tanks. SANI 360 IS TRUSTED BY OVER 5 MILLION USERS. Sold on Amazon for more than 8 years.
  • EASY MONTHLY DRAIN MAINTENANCE FOR DRAIN ODORS: Drop 1 Sani Stick a month in the drain (depending on the frequency of drain use) to keep drain pipes clean and water flowing and odor-free. Each Sani Stick continuously releases a super-concentrated blend of powerful natural enzymes over time that will eliminate drain odors and dissolve food, grease, and organic materials.
  • CONCENTRATED-ENZYME DRAIN CLEANER: Sani Sticks drain cleaners and deodorizers are ideal for home and commercial use. Each of the sticks rests in the pipe trap, releasing enzymes to break down oil and other drain buildup from food, soap, and body wash that gets stuck and causes foul odor inside the drain.
  • SAFE TO USE IN ALL DRAINS: Sani Sticks fresh unscented odor-eliminating sink-cleaner sticks only use enzymes to clean, so they’re safe for use in all drains, from the bathroom to the kitchen. Keep your drains safer and smelling fresher with this drain and odor-remover monthly treatment. Sani Sticks are available in many fresh scents, including lemon, lavender, lime honey, orange, pine, apple cinnamon, oak moss, and forest snow.
  • KEEP WATER FLOWING STRONG & DRAINS ODOR-FREE: Save time and money by avoiding extra plumber visits with this effective drain-cleaner odor eliminator. Instead of wrangling with drain snakes, simply insert 1 stick a month into each of your drains to prevent water buildup and keep your drains smelling fresh.
No. 7
Biokleen Bac-Out Enzymatic Drain Cleaner - 32 Ounce (2 Pack) - Enzyme Prevents Clogs, Eco-Friendly, Live Enzyme-Producing Cultures and Plant Extracts, No Artificial Fragrance or Preservatives
  • PREVENTS DRAIN CLOGS AND ELIMINATES ODORS: Bac-Out Drain Care prevents clogs, and eliminates tough odors. Its gel coating action thoroughly coats pipes to treat slow drains
  • KEEPS PETS AND KIDS IN MIND: Bac-Out Drain Care leaves no harsh fumes or residue, just cleaner pipes and less odor.
  • BIO-ACTIVE FORMULA: A unique blend of live enzyme cultures breakdown and absorb organic material. It's a more natural way to remove buildup and stinky odors.
  • PLANT-BASED PRODUCT: Bac-Out uses a plant-based, eco-friendly solution with no artificial fragrances or dyes. Our products never contain phosphates, chlorine, ammonia, or brighteners.
  • MADE IN THE USA: We use biodegradable ingredients, never test on animals, and are manufactured in the USA with US and imported parts
No. 8
Flo-Kem 5195 Flo-Zyme Commercial Bio-Enzyme Drain Opener/Deoderizer with Pleasant Scent, 1 Gallon Bottle, Milky White
  • Heavy duty enzyme formula for opening up tough clogged drains
  • Breaks down and liquifies suspended solids like fats, oils, greases and other proteins
  • Eliminates foul odors
  • Use to maintain kitchen and bathroom sinks, tub and floor drains, urinals, grease traps and septic tanks.
  • Use 2-4 oz. at night for sinks and drains. Safe on all types of pipes.
No. 9
Instant Power Commercial Drain Maintainer - Liquid Enzyme Clog Remover, Cleans and Deodorizes, Reduces Drain Blockages, 1 Gal
  • CLEANS AND DEODORIZES: Bad odors in your kitchens and restrooms could indicate that your drain system is clogged; Instant Power clogged drain cleaner removes blockages, clears odor-causing build-up
  • EFFECTIVE CLOG REMOVER: Our clog remover uses enzymes to breakdown and rinse away grease, food particles, and other materials that get stuck in your drainage over time
  • REDUCES COST: Our drain clog remover reduces drain blockage emergencies that disrupt business operations and minimizes the need for frequent grease trap pumping
  • NO HARSH CHEMICALS: Instant Power Enzyme Drain Cleaner does not use harmful acids and caustic ingredients; It contains powerful enzymes that clear clogs but is safe on your pipes and drainage
  • ECO-FRIENDLY: Our environmentally friendly formula will digest fats, oils, and greases along with other organic waste that accumulate in drains and grease traps
  • Reduces fat, oil & grease build-up in drains
  • Reduces grease trap pumping
  • Eliminates odors
  • Environmentally friendly contents
  • Treats kitchen and restroom drains, plus grease traps
SaleNo. 10
Green Gobbler Drain Cleaner & Deodorizer FRESH SCENT Sticks for Toilet Tanks, Sinks, Bathtub Drains, Washing Machine Drains and Garbage Disposals - 24 Pieces
  • PREVENT FOUL ODORS: One Green Gobbler Drain Stick will help remove organic matter that can be the starting point for stinky odors and clogs. It works hard to deodorize pipes and attacks grease, food, fats, oils and scum that cause slow-moving drains.
  • ENZYME ENHANCED FORMULA: Simply drop one stick into your drain and the highly-concentrated and enzyme enhanced formula will start to work immediately. Use one a month. Each pack comes with a 12-month supply.
  • SAFE FOR ALL PIPES & SEPTIC: Green Gobbler Drain Sticks are safe for use in sinks, tubs, garbage disposals, toilet tanks, washing machine drains and septic systems. The strips will naturally break down over time.
  • POWERFUL YET SLOW DISSOLVING: Green Gobbler Strips destroy nasty drain odors over time. In a few weeks, you'll notice those drain odors disappearing.
  • GREEN GOBBLER GUARANTEE: Green Gobbler cares about its customers. We take pride in developing innovative & effective products for your home or business. If for any reason you are unsatisfied, please contact us. We offer a money-back guarantee within 30 days of purchase.

How to choose a good enzyme for drains

Does the idea of finding a fantastic enzyme for drains make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in enzyme for drains. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top enzyme for drains products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top enzyme for drains on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top enzyme for drains brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top enzyme for drains based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the enzyme for drains were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good enzyme for drains, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your enzyme for drains.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting enzyme for drains for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our enzyme for drains. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what enzyme for drains should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on enzyme for drains.