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The 8 Best eye drop for dry eyes preservative free of 2025

Are you trying to find eye drop for dry eyes preservative free among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling eye drop for dry eyes preservative free on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 12 hours of research and did 30 eye drop for dry eyes preservative free tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best eye drop for dry eyes preservative free you can buy today

SaleNo. 1
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
  • Fast acting hydration for sensitive eyes
  • Preservative free tear evaporation protection
  • Nano droplets for better coverage
SaleNo. 2
Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)
  • Preservative-Free Lubricant Eye Drops
  • Fast-Acting Hydration and lasting dry eye relief
  • Moisture rich formula eye drops for sensitive eyes
  • Tear evaporation protection for high-performance dry eye symptom relief that lasts
SaleNo. 3
TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials
  • TheraTears Dry Eye Therapy Lubricant Eye Drops, Preservative Free, provide immediate, long-lasting relief of dry eye symptoms
  • Discover TheraTears eye drops, one-of-a-kind silky hydration for dry eyes
  • TheraTears Dry Eye lubricating eye drops contain the 5 vital electrolytes found in natural tears
  • TheraTears corrects the salt imbalance that can cause dry eye symptoms
  • Preservative free for sensitive eyes; the single-use vials come in a foil pouch to ensure freshness
  • Doctor recommended and created; TheraTears was created by an ophthalmologist after 18 years of research
  • Contains 1 box of TheraTears Dry Eye Therapy Lubricant Drops, Preservative Free, 30 vials
  • FSA- and HSA-eligible product in the U.S.
No. 4
Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary
  • Original strength, preservative-free formula
  • Relieves mild symptoms of eye dryness
  • Instantly moisturizes and lubricates
  • Designed to act like your own natural tears
  • Great for sensitive eyes
  • Value size. 50 on-the go, single-use vials
  • Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
  • The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
SaleNo. 5
Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)
  • Hydrates fast and provides long-lasting relief for dry eyes
  • Preservative free eye drops
  • Contains hyaluronate for advanced hydration
  • Safe for use with all contact lenses
  • Extra moisturizing eye drops for sensitive eyes
SaleNo. 6
Refresh Plus Lubricant Eye Drops For Dry Eyes, Preservative-Free,Value Size, 0.01 Fl Oz Single-Use Containers, 70 Count
  • Original strength, preservative-free formula
  • Relieves mild symptoms of eye dryness
  • Instantly moisturizes and lubricates
  • Designed to act like your own natural tears
  • Great for sensitive eyes
  • Value size. 70 on-the go, single-use vials
  • Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
  • The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
  • Active Ingredient: Carboxymethylcellulose Sodium (CMC) (0.5%); Inactive Ingredients: Calcium Chloride, Magnesium Chloride, Potassium Chloride, Purified Water, Sodium Chloride, and Sodium Lactate. May also Contain Hydrochloric Acid and/or Sodium Hydroxide to Adjust pH.
SaleNo. 7
iVIZIA Sterile Lubricant Eye Drops for Dry Eyes, Preservative-Free, Moisturizing, Dry Eye Relief, Contact Lens Friendly, 0.16 fl oz Bottle Packaging May Vary
  • Your Dry Eyes Deserve Better: iVIZIA Dry Eye drops are scientifically formulated to moisturize and lubricate dry eyes and relieve discomfort and eye strain due to dryness.
  • Unique Formulation: Hydrating polymers form a protective matrix, moisturizing Hyaluronic Acid holds up to 1000x its weight in moisture, and Trehalose (synthetic ingredient also found in desert plants).
  • Free of Irritating Preservatives: Sterile, safe for use with contact lenses
  • Patented ABAK Bottle: preservative-free, dispenses drop-by-drop, and does not stream. The ergonomic bottle is easy to open, easy to hold and squeeze.
  • iVIZIA – We See a Better Way: for healthy, comfortable eyes
SaleNo. 8
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers
  • FAST-ACTING: Rapid relief to comfort dry, irritated eyes
  • LASTING RELIEF: Soothes and prevents further irritation
  • TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
  • PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
  • ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
  • ON-THE-GO VIALS: 60 sterile single-use vials per carton that are easy and safe to use as often as needed
  • TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
  • FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan
No. 9
Blink Boost Preservative-Free Lubricating Eye Drops, Eye Care Drops for Dry Eyes, Instant Moisture for Dry Irritated Eyes & Comfort Throughout the Day, Contact Lens Friendly, 10 mL
  • Preservative-Free Formula: Blink Boost Lubricating Eye Drops provide fast-acting relief from dryness and discomfort. The preservative-free formula is pH balanced to mimic natural tears, offering extra hydration and helps relieve dry eyes
  • Advanced Long-Lasting Hydration: Infused with hyaluronan, an electrolyte, and an antioxidant, these dry eyes eye drops enhance moisture retention while relieving discomfort from irritants like wind or sun, & provides comfort throughout the day
  • Gentle on Eyes: These lubricant eye drops for dry eyes soothe dryness & irritation without preservatives. Whether indoors or outdoors, they help keep your eyes comfortable & include HA and an electrolyte, found naturally in tears
  • Trusted Brand: There is a range of Blink products to meet your eye care needs, from dry eye drops to lock in moisture to preservative-free formulas. Blink products provide comfort, hydration, and relief from dry eyes
  • Reduce Everyday Discomfort: Blink eye drops are for the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. The drops are also contact lens friendly.
SaleNo. 10
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 10ml
  • Fast acting hydration for sensitive eyes
  • Preservative free tear evaporation protection
  • Nano droplets for better coverage
No. 11
Biotrue Hydration Boost, Preservative-Free Eye Drops for Dry Eyes, Instantly Moisturizes, Clears and Rehydrates, Contact Lens Friendly, Refresh & Relieve Eye Irritation, 0.33 FL Oz (Pack of 2)
  • NATURALLY INSPIRED INGREDIENTS: Biotrue Hydration Boost Eye Drops are enhanced with HA (Hyaluronan), Antioxidant, and Electrolyte and provide instant moisture for dry eyes.
  • INSTANT MOISTURE: For dry, irritated eyes due to screen and environmental stressors.
  • Special preservative free, multi-dose bottle.
  • BIOTRUE EYE DROPS: Not only are the Hydration Boost Eye Drops free of preservatives but they are also pH balanced for comfort.
  • EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solutions to eye drops, vitamins, & ointments to help your eyes feel moisturized and protected.
SaleNo. 12
Systane Ultra Lubricant Eye Drops, 60 Count (Pack of 1), (Packaging may vary)
  • #1 Dr Recommended Brand of Artificial Tears*
  • Extended Protection
  • Fast Long-Lasting Dry Eye Symptom Relief
  • Reduces both the signs and symptoms of dry eye
  • Single-Use Convenience. Store at room temperature
SaleNo. 13
OCuSOFT Retaine MGD Ophthalmic Emulsion - Complete Dry Eye Relief - Soothes Red & Irritated Eyes - 30 Count Preservative-Free Single-Use Containers - 0.01 Fl Oz
  • Retained mgd is a revolutionary preservative-free ophthalmic emulsion that moisturizes, lubricates and protects moderate to severe dry eyes
  • Provides long-lasting relief utilizing nova orb,
  • Proprietary cationic oil emulsion technology that effectively delivers ingredients through electrostatic attraction between positively charged droplets and the negatively charged ocular surface
  • Retained MGD is a revolutionary preservative-free ophthalmic emulsion that moisturizes, lubricates and protects moderate to severe dry eyes.
  • The hypo tonicity of the emulsion adds moisture by lowering the salt concentration of tears while the lipid component lubricates and protects the surface of the eye.
  • Retained MGD is a revolutionary preservative-free ophthalmic emulsion that moisturizes, lubricates and protects moderate to severe dry eyes.
  • Provides long-lasting relief utilizing Nova orb,
  • proprietary cationic oil emulsion technology that effectively delivers ingredients through electrostatic attraction between positively charged droplets and the negatively charged ocular surface.
  • The hypo tonicity of the emulsion adds moisture by lowering the salt concentration of tears while the lipid component lubricates and protects the surface of the eye.
SaleNo. 14
Refresh Optive Advanced Lubricant Eye Drops For Dry Eyes, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 30 Count
  • Preservative-free triple-action relief drop
  • Lubricants and hydrates dry, burning, irritated eyes
  • Helps prevent tears from evaporating
  • Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
  • Recommended for sensitive eyes
  • On-the-go single use vials
  • The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
SaleNo. 15
Systane Complete Unit-Dose Preservative-Free Eye Drops 30ct Single-use vials for Dry Eye Relief
  • Systane’s most advanced formula for dry eye now available in preservative-free single-use vials
  • One Drop. 8 Hours Dry Eye Relief
  • From #1 Dr. Recommended Brand for Dry Eye Relief
  • Artificial tears for all major types of dry eye
  • Fast acting hydration and dry eye relief for sensitive eyes
No. 16
Optase Dry Eye Intense Drops - Preservative Free Eye Drops for Long Lasting Relief - Artificial Tears to Relieve Severe Dry Eye Symptoms - Multidose Bottle - Step 3 Hydrate - .33 fl oz, 300 Doses
  • MOISTURIZE AND PROTECT: Made of glycerin and quality ingredients, Optase Dry Eye Intense Drops mix with the natural oils needed to protect your tears and hydrate your eyes to improve tear quality
  • PRESERVATIVE FREE: Optase Intense Eye Drops is the only product of its kind to provide a preservative free combination of ingredients designed to treat dry eye patients in a unique multi-dose bottle
  • MODERATE TO SEVERE DRY EYE RELIEF: The long lasting formulation of Optase Intense provides comfort for dry eye and post operative patients. And it is contact lens safe, providing relief when needed
  • ADVANCED BOTTLE TECHNOLOGY: A convenient multi-use drop bottle with advanced technology maintains sterility over 3 months without preservatives. Avoid the hassle of individual vials while on the go
  • COMPLETE DOCTOR RECOMMENDED EYE CARE RELIEF: OPTASE is the expert recommended 3-step regimen to help tackle the cause and symptoms of Dry Eyes, Blepharitis and Meibomian Gland Dysfunction (MGD)
SaleNo. 17
Refresh Optive Lubricant Eye Drops Preservative-Free Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers
  • Dual-action formula lubricates and hydrates
  • Relieves mild symptoms of eye dryness
  • Works fast by delivering soothing moisture
  • Preservative-free for sensitive eyes
  • Value size: 60 on-the go, single-use vials
  • Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
  • The selling brand in preservative-free artificial tears; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
SaleNo. 18
Systane PRO PF Multi-dose Preservative-Free Lubricant Eye Drops 2 Count
  • Triple-Action Dry Eye Relief: Systane Pro Preservative Free Eye Drops hydrate, restore and protect dry eyes for long-lasting relief
  • Long-Lasting Hydration: Systane Pro Preservative Free lubricating eye drops are formulated with Hyaluronate, a moisturizer that occurs naturally in tears, to support extended hydrationfor all types of dry eye relief
  • Tear Evaporation Protection: This unique formula enhanced with lipid nanodroplets helps lock in moisture and reduce tear evaporation
  • Preservative-Free Formula: The gentle, preservative-free formula is ideal for sensitive eyes
  • Trusted Brand: Systane is a trusted name in eye care, recommended by eye care professionals for its effective and reliable relief from dry eyes
  • Convenient Size: The 10mL oz bottle is perfect for daily use, offering you triple action dry eye relief at your fingertips
  • Contact Lens Friendly^: safe for use with soft contact lenses
SaleNo. 19
Systane Pro PF Dry Eye Relief Preservative Free Lubricant Eye Drops 10 mL
  • Triple-Action Dry Eye Relief: Systane Pro Preservative Free Eye Drops hydrate, restore and protect dry eyes for long-lasting relief
  • Long-Lasting Hydration: Systane Pro Preservative Free lubricating eye drops are formulated with Hyaluronate, a moisturizer that occurs naturally in tears, to support extended hydration
  • Tear Evaporation Protection: This unique formula enhanced with lipid nanodroplets helps lock in moisture and reduce tear evaporation
  • Preservative-Free Formula: The gentle, preservative-free formula is ideal for sensitive eyes
  • Trusted Brand: Systane is a trusted name in eye care, recommended by eye care professionals for its effective and reliable relief
  • Convenient Size: The 10mL oz bottle is perfect for daily use, offering you triple action dry eye relief at your fingertips
  • Contact Lens Friendly*: safe for use with soft contact lenses
No. 20
OPTASE HYLO Relief Dry Eye Drops - Fast-Acting Preservative Free Drops with Patented HYLO Delivery System - Artificial Tears for Mild to Moderate Dry Eye Relief - .33 Oz, 300 Doses
  • PRESERVATIVE AND PHOSPHATE FREE FORMULA - Made with moisturizing hyaluronic acid and glycerin, OPTASE HYLO Relief uses a phosphate and preservative free artificial tears formula for dry eye relief
  • NO WASTED EYE DROPS - The innovative, one-click, multi-use bottle of OPTASE HYLO Relief dry eyes eye drops provides 300 calibrated doses, while maintaining sterility for 6 months after opening
  • MILD TO MODERATE DRY EYE RELIEF - OPTASE HYLO Relief drops provides comfortable relief from mild to moderate dry eye symptoms. Plus, it is contact lens safe for convenient use throughout the day
  • INNOVATIVE BOTTLE DESIGN – OPTASE HYLO Relief’s unique bottle technology releases one drop of lubricating eye drops with just a press, with no waste – simply grip, position, and click
  • PAIR WITH OPTASE HYLO NIGHT – For optimal results, use OPTASE HYLO Relief moisturizing eye drops with OPTASE HYLO Relief Nighttime Eye Gel as part of the complete line of expert dry eye relief

How to choose a good eye drop for dry eyes preservative free

Does the idea of finding a fantastic eye drop for dry eyes preservative free make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in eye drop for dry eyes preservative free. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top eye drop for dry eyes preservative free products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top eye drop for dry eyes preservative free on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top eye drop for dry eyes preservative free brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top eye drop for dry eyes preservative free based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the eye drop for dry eyes preservative free were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good eye drop for dry eyes preservative free, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your eye drop for dry eyes preservative free.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting eye drop for dry eyes preservative free for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our eye drop for dry eyes preservative free. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what eye drop for dry eyes preservative free should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on eye drop for dry eyes preservative free.