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The 8 Best home genetic tests of 2025

Are you trying to find home genetic tests among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling home genetic tests on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 27 hours of research and did 20 home genetic tests tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best home genetic tests you can buy today

No. 1
MTHFR+COMT Methylation Genes Test Kit. 1-on-1 Live Expert Support by Phone 7 Days A Week. MTHFR C677T + A1298C and COMT V158M Gene Variants for Methylation Analysis +. Results in 2-5 Days. Ages 0+
  • ✅ Get personalized supplement recommendations based on Ricardo Miranda's unique methylation protocol. Widely recognized as The MTHFR Pioneer (video attached), he is a leading MTHFR researcher and physician specializing in methylation health. With extensive experience coaching doctors nationwide and assisting thousands of patients, his expert guidance is tailored to your unique genetic profile, ensuring you benefit from proven, science-backed strategies for optimal health and wellness.
  • ✅ Focused Efficacy: Our test identifies every possible mutation in the MTHFR and COMT genes, providing you with accurate details about your genetic makeup. By focusing specifically on these critical genes, our product delivers vital insights that significantly impact your methylation processes and mental health. This targeted approach promotes a more sustainable health strategy, ensuring precise and effective outcomes for enhanced well-being. Results in 2-5 days from the day our lab receives your specimen.
  • ✅ Comprehensive Support: Get access to our expert team seven days a week through live phone support. Our knowledgeable specialists are ready to provide detailed explanations and answer your specific questions. For complex cases requiring specialized expertise, you can request to speak directly with Ricardo Miranda, the leading authority in methylation health.
  • ✅ Simple and Convenient Testing: Collect the MTHFR + COMT gene test sample at home. This product delves deeper into methylation, focusing on the most significant genes. By including the COMT gene, we further explore the genes that impact methylation and mental well-being.
  • ✅ Reliable, Accurate, and Safe Results: Trust our MTHFR testing kit for its precision and thorough analysis, which focuses on the most impactful genetic information related to your methylation and mental health. Our commitment to quality ensures that you receive dependable insights into your wellness. Your results are 100% secure with us. We uphold the strictest privacy standards and never share or sell your information to any third party. Our robust data protection protocols use encryption and are SOC2 compatible to ensure that your personal details remain confidential and secure.
  • ✅ Empower Your Knowledge: Use the results to make informed decisions about your lifestyle with the support of our expert team. We understand that DNA test results can be confusing, so our expert team is available by phone to provide you with all the support you need.
  • ✅ When collecting a cheek swab from babies and toddlers, you can skip the standard pre-swab instructions and proceed directly with swabbing both cheeks. Just ensure the mouth is free of any food particles.
No. 2
MTHFR-Gene Methylation Test Kit. 1-on-1 Live Expert Support by Phone 7 Days A Week, MTHFR C677T and MTHFR A1298C Gene Variants for Methylation Analysis. Results in 2-5 Days. Ages 0+
  • ✅ Get personalized supplement recommendations based on Ricardo Miranda's unique methylation protocol. Widely recognized as The MTHFR Pioneer (video attached), he is a leading MTHFR researcher and physician specializing in methylation health. With extensive experience coaching doctors nationwide and assisting thousands of patients, his expert guidance is tailored to your unique genetic profile, ensuring you benefit from proven, science-backed strategies for optimal health and wellness.
  • ✅ Comprehensive Mutation Analysis: Our test identifies every possible mutation in the MTHFR gene, providing you with precise information about your genetic makeup. Recognizing that navigating DNA results can be challenging, our dedicated specialists are just a phone call away, ready to assist you with any questions or concerns you may have.
  • ✅ Comprehensive Support: Get access to our expert team seven days a week through live phone support. Our knowledgeable specialists are ready to provide detailed explanations and answer your specific questions. For complex cases requiring specialized expertise, you can request to speak directly with Ricardo Miranda, the leading authority in methylation health.
  • ✅ Simple, Non-Invasive Sampling: Our MTHFR gene test involves an easy-to-use cheek swab, designed for pain-free collection in the comfort of your home. This non-invasive method makes genetic testing straightforward and stress-free, ideal for individuals of any age, including toddlers and babies.
  • ✅ Targeted Efficacy: Our product is engineered to provide the most relevant insights for managing your methylation health effectively, promoting a focused approach to long-term wellness. This ensures that you receive the most practical and impactful recommendations tailored to your needs.
  • ✅ Reliable, Accurate, and Safe Results: Trust our MTHFR testing kit for its precision and thorough analysis, which focuses on the most impactful genetic information related to your methylation health. Our commitment to quality ensures that you receive dependable insights into your wellness. Your results are 100% secure with us. We uphold the strictest privacy standards and never share or sell your information to any third party. Our robust data protection protocols use encryption and are SOC2 compatible to ensure that your personal details remain confidential and secure.
  • ✅ When collecting a cheek swab from babies and toddlers, you can skip the standard pre-swab instructions and proceed directly with swabbing both cheeks. Just ensure the mouth is free of any food particles. Results in 2-5 days from the day our lab receives your specimen.
No. 3
AncestryDNA + Traits Genetic Test Kit: Personalized Genetic Traits, DNA Ethnicity Test, Origins & Ethnicities, Complete DNA Test, Ancestry Reports
  • TOP-SELLING CONSUMER DNA TEST: From your origins in over 2,600 global regions to the most connections to living relatives, no other DNA test kit delivers an experience as unique and interactive as AncestryDNA
  • DNA + TRAITS: Ever wondered where your freckles came from, or why you hate cilantro? AncestryDNA + Traits lets you discover 40+ genetic traits, allowing you to explore how your genes might have influenced a range of appearance, sensory, fitness, nutrient, and other personal characteristics
  • A FEW SIMPLE STEPS: Simply activate your DNA kit online and return your saliva sample in the prepaid package to our state-of-the-art lab. Your results will be available online in roughly six to eight weeks
  • ETHNICITY ESTIMATES AND INHERITANCE: AncestryDNA provides a more precise ethnicity estimate with greater geographic detail. Our innovative SideView technology takes your results even further by showing your ethnicities and matches by parental side. *Some DNA features may require an Ancestry subscription
  • PROTECTING PRIVACY: We employ industry-standard security measures in every stage of our process. Using data encryption, secure databases, and easy-to-use controls, we protect your data and give you control over it
No. 4
empowerDX MTHFR Gene Test Kit, Methylation Test, Easy at-Home Test Detects Presence of 677 and 1298 MTHFR Gene Variants, Ages 2+, Fast Results Within 6 Days
  • TEST FOR VARIANTS OF MTHFR: Verify if you have a variant of the methylation gene; certain MTHFR gene variants may affect your ability to mentally thrive
  • WHAT IS MTHFR: The MTHFR gene helps folate work in your body, helps to regulate homocysteine (which can damage blood vessels when elevated), and plays a role in making dopamine, serotonin, and norepinephrine; variants of the MTHFR gene can be associated with mental health issues, depressed mood, fertility, anxious feelings, fetal development, and migraine headaches
  • EASY TO USE AT-HOME MTHFR TEST KIT: Requires an easy mouth swab for DNA test sample collection; Emerging research is studying the association between MTHFR gene variants and autism spectrum disorder, ADHD, autoimmune disease, Alzheimer’s disease, and much more
  • CERTIFIED LAB: empowerDX laboratories are certified by several different organizations and ensure that their methods and practices meet rigorous standards
  • SECURE & EASY TO READ RESULTS: MTHFR test results will be accessed privately through a secure online portal; a test guide will be provided on how to read and understand your results, which will reveal if there are any variations in the two MTHFR genetic markers
No. 5
tellmeGen Advanced DNA Test:400+ Health, Ancestry, Traits & Fitness Reports - Fees Included - Lifetime Updates
  • FOR INFORMATIONAL PURPOSES: The information provided by tellmeGen, although useful, is solely for informational purposes and is not intended to diagnose health conditions. Use it as a guide to better understand yourself, but always consult a healthcare professional for any medical actions.
  • 7 GENETIC ANALYSES IN 1: tellmeGen offers more than 400 detailed reports related to genetic health, inheritance, pharmacogenetics, ancestry, well-being, and personal traits. Receive your results in just 4-6 weeks. Get useful and always up-to-date information at no extra cost.
  • HEALTH, ANCESTRY, AND TRAIT ANALYSIS: Deepen your understanding of your genetic information with more than 200 aspects related to your health and genetic inheritance. Discover your origins and connect with global relatives through your DNA.
  • ACCESS TO DNA CONNECT: Find and connect with relatives worldwide who share your DNA, using our secure and user-friendly platform.
  • FREE AND CONSTANT UPDATES: Our genetic studies are regularly reviewed to provide you with the most up-to-date information at no additional cost, keeping you informed of the latest scientific advancements.
  • GUARANTEED SECURITY AND PRIVACY: With tellmeGen, your privacy is protected. We use data encryption and guarantee the reliability of your genetic information, obtained from a simple saliva sample taken from the comfort of your home.
No. 6
AncestryDNA Genetic Test Kit: Personalized Genetic Results, DNA Ethnicity Test, Origins & Ethnicities, Complete DNA Test
  • TOP-SELLING CONSUMER DNA TEST: From your origins in over 2,600 global regions to the most connections to living relatives, no other DNA test kit delivers an experience as unique and interactive as AncestryDNA
  • A FEW SIMPLE STEPS: Simply activate your DNA kit online and return your saliva sample in the prepaid package to our state-of-the-art lab. Your results will be available online in roughly six to eight weeks
  • ETHNICITY ESTIMATES AND INHERITANCE: AncestryDNA provides a more precise ethnicity estimate with greater geographic detail. Our innovative SideView technology takes your results even further by showing your ethnicities and matches by parental side. *Some DNA features may require an Ancestry subscription
  • BUILD YOUR FAMILY TREE: Combine what you learn from your DNA results with an Ancestry subscription and gain access to millions of family trees and the world's largest collection of online family history records. *Access to record collections varies depending on subscription level
  • PROTECTING PRIVACY: We employ industry-standard security measures in every stage of our process. Using data encryption, secure databases, and easy-to-use controls, we protect your data and give you control over it
No. 7
HomePaternity Sibling DNA Test, Fast Results, Highest Accuracy Available with Up to 34 Genetic Markers Tested, All Lab Fees & Shipping Included
11 Consomer Reviews
HomePaternity Sibling DNA Test, Fast Results, Highest Accuracy Available with Up to 34 Genetic Markers Tested, All Lab Fees & Shipping Included
  • ABOUT OUR SIBLINGSHIP DNA TEST: This DNA test will determine if two individuals are full siblings (brothers or sisters), half-siblings, or are not siblings at all using a simple at-home kit including cheek swabs from each party.
  • FAST RESULTS: Receive your results within 5 days after your sample is delivered to our lab via our secure online portal. Due to New York State law, this test is NOT AVAILABLE to residents of New York.
  • MAXIMUM ACCURACY: We test up to 34 genetic markers and perform each test TWICE our in-house AABB, ISO 17025, CAP, and CLIA accredited laboratory to deliver maximum accuracy.
  • EASY SAMPLE COLLECTION: Collect your DNA sample with our easy-to-use mouth swabs, then return in the pre-paid mailer. No additional fees. Includes testing for 2 individuals, plus option to include the mother for siblings that share a mother for no additional charge.
  • ACCREDITED, IN-HOUSE LAB: As a world leader in DNA testing with over 25 years of experience and over 20 million tests performed, we don’t use third-party labs - All test samples are processed in our accredited, in-house lab based in the U.S.A.
  • Discreet Testing: Discreet packaging and results without names on the report, ensuring privacy. Note: results are not for legal use or court submission.
No. 9
COMT Gene Test Collection Kit Comes with Results Interpretation and Live Support 7 Days a Week - Cheek Swab -
  • ✅ Includes results interpretation and LIVE SUPPORT via phone seven days a week. We offer real-time assistance to help you comprehend your results and their significance to you.
  • ✅ Simple, Non-Intrusive Collection: Our COMT gene test requires just an easy cheek swab, ensuring the process is pain-free and non-intrusive. You can gather your sample easily at home.
  • ✅ Our at-home genetic test kit is dedicated to analyzing the COMT gene, offering important insights through a straightforward cheek swab. Fast results.
  • ✅ The outcomes will indicate whether there are any variations in your COMT genetic marker. You can access the results via a secure online portal.
  • ✅ Dependable and Precise Outcomes: Have confidence in the excellence and precision of our COMT genetic testing kit. It delivers an in-depth examination of your COMT genetic data, enabling you to make informed decisions about your lifestyle.
  • ✅ When collecting a cheek swab from babies and toddlers, you can skip the standard pre-swab instructions and proceed directly with swabbing both cheeks. Just ensure the mouth is free of any food particles.

How to choose a good home genetic tests

Does the idea of finding a fantastic home genetic tests make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in home genetic tests. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top home genetic tests products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top home genetic tests on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top home genetic tests brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top home genetic tests based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the home genetic tests were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good home genetic tests, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your home genetic tests.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting home genetic tests for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our home genetic tests. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what home genetic tests should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on home genetic tests.