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The 8 Best l lysine supplements of 2025

Are you trying to find l lysine supplements among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling l lysine supplements on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 21 hours of research and did 64 l lysine supplements tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best l lysine supplements you can buy today

SaleNo. 1
NOW Foods Supplements, (L-Lysine Hydrochloride) 1,000 mg, Double Strength, Amino Acid, 100 Tablets
  • DOUBLE STRENGTH VEGAN TABLETS/ESSENTIAL AMINO ACID: Lysine is an essential amino acid that must be obtained through diet or supplementation
  • SUPPORTS COLLAGEN SYNTHESIS*: Necessary for the production of all proteins in the body and is required for the maintenance of the structural proteins collagen and elastin*
  • CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Non-GMO, Vegan/Vegetarian, Nut Free, Made without Gluten, Dairy Free, Egg Free, Kosher
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
  • Packaged in the USA by a family owned and operated company since 1968
SaleNo. 2
Nature Made Extra Strength L-Lysine 1000 mg Tablets, 60 Count for Protein Synthesis
  • Contains a 60-day supply of Nature Made L-Lysine 1000 mg Tablets, 60 tablets per bottle.
  • Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
  • Essential amino acid
  • Adults, take 1 tablet daily with water and a meal.
  • Guaranteed to meet our high quality standards. Made from carefully selected ingredients under strict manufacturing processes. No color added, no artificial flavors, no preservatives, gluten free.
  • These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
SaleNo. 3
NOW L-Lysine 500 mg,250 Capsules
4,064 Consomer Reviews
NOW L-Lysine 500 mg,250 Capsules
  • ESSENTIAL AMINO ACID: L-Lysine is an essential amino acid, which means that it cannot be manufactured by the body and must be obtained through the diet or by supplementation.
  • SUPPORTS HEALTHY CONNECTIVE TISSUE AND CALCIUM ABSORPTION: Lysine is necessary for the production of all protein in the body including hormones, enzymes, and antibodies, as well as carnitine and collagen, which is the structural protein forming all connective tissue such as skin, tendon, and bone. L-Lysine also plays a major role in calcium absorption.
  • CLASSIFICATIONS/CERTIFICATIONS: Non-GMO, Dairy Free, Egg Free, Made without Gluten, Nut Free, Soy Free, Vegan/Vegetarian
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
  • Packaged in the USA by a family owned and operated company since 1968
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
No. 4
Pure Encapsulations L-Lysine - Essential Amino Acid Supplement for Immune Support & Gum, Lip Health* - with L-Lysine HCl - 90 Capsules
  • Essential Amino Acid: L-Lysine is one of several essential amino acids that cannot be manufactured by the body; supports body's natural defenses*
  • Lysine Supplement for Immune Support: L-Lysine provides nutritional support to help maintain immune function and immune system*
  • Natural Defense Support: These essential L-Lysine capsules maintain arginine production and support the body's natural immune defenses*
  • Pure Quality: Our supplements are made with premium ingredients sourced from trusted suppliers and guided by nutritional experts, then manufactured and tested to verify potency and purity
  • Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs
No. 5
Bronson L-Lysine Defense Immune Support Complex 1500 MG L-Lysine Plus Olive Leaf, Garlic, Vitamin C and Zinc - Non-GMO, 90 Vegetarian Capsules
  • L-Lysine Defense Complex: L-Lysine is an essential amino acid that is obtained through foods and supplementation. It’s thought that L-Lysine helps to maintain healthy production of the amino acid L-Arginine. L-Lysine helps to keep L-Arginine within a healthy range and support overall immune health.*
  • Plus Olive Leaf, Garlic, Vitamin C & Zinc: L-Lysine combined with key additional immune support ingredients for superior coverage. Combining natural herbal ingredients, such as Olive Leaf and Garlic, which have been used throughout history in various cultures to support immune health.* Additionally includes Vitamin C and Zinc to help replenish the body with essential nutrients to help maintain a healthy immune system.*
  • Highest Quality Formula: Laboratory tested NON-GMO. All Bronson products are tested in our state-of-the-art cGMP registered facility in New York.
  • Trusted Since 1960: The pioneers of Bronson Vitamins were a group of pharmacists who witnessed the benefits of vitamins and mineral supplementation firsthand with their patients. Bronson Vitamins have been consistently mentioned by top medical professionals since our inception in 1960.
No. 6
Vimergy L-Lysine – Promotes Healthy Skin, Hair, Nails & Joints* – Supports Healthy Metabolism* – Vegan, Non-GMO & Gluten-Free – 270 Capsules
  • SUPERIOR FORMULA WITH ONLY 3 INGREDIENTS. Lysine is one of the essential amino acids for humans, meaning that it’s necessary for our health but our bodies can’t produce it naturally, so we have to provide it for ourselves through diet and supplementation.* The Vimergy formula contains only 3 recognizable ingredients and delivers all the lysine you need in one daily capsule.
  • SUPPORTS HEALTHY JOINTS & SKIN + METABOLISM.* The amino acid L-lysine supports production of collagen,* a structural protein that’s important inside the body (ligaments, tendons, and blood vessels), as well as outside the body (skin, hair, and nails). L-lysine is also essential for synthesis of carnitine, which is necessary for healthy fat metabolism.*
  • VEGAN SOURCE OF HIGH-CONCENTRATION LYSINE. Lysine occurs naturally in many of the foods we eat. The primary dietary sources of lysine are animal products — meats and dairy items. If you’re on the vegan path, Vimergy capsules are your go-to source. Some cereal grains and veggies carry lysine, but only small amounts. A daily capsule of our product offers a full serving of 500mg.
  • EXPERIENCE MIXOLOGY BY VIMERGY. As someone who takes charge of their well being, you decide what your body needs. That’s why it’s essential to incorporate Vimergy products into your daily routine. Unlike multivitamins, our capsules provide plenty of versatility. They’re a convenient “on the go” form of supplementation that can also be opened and added to smoothies. We provide the ultimate in mixology-based customization to support your health and wellness.
  • PEACE OF MIND CLEAN. Vimergy is triple third party verified for your peace of mind, and Vimergy lysine is a natural supplement that comes in a clean capsule format you can trust. Our product is formulated with no gelling agents, no gluten, no corn, no soy, no alcohol, and no unnecessary colors or fillers. We offer a clean vegan supplement that’s non-GMO, gluten-free, and paleo-friendly.
No. 7
NatureBell L-Lysine 1,000mg Capsules + Quercetin 250mg with Vitamin C and Zinc, 240 Count | Free Form Amino Acids, L Lysine Complex | Immune Support, Lip & Skin Health Supplement
  • NatureBell double strength lysine supplement, advanced LysGuard complex, 4 in 1 super health nutrients from free forming lysine hydrochloride, vitamin C, quercetin dihydrate, and zinc picolinate.
  • LysGuard is a powerful amino acid nutritional complex for men and women, a combination of immune vitamins, minerals, and plant compounds for adults.
  • 240 potent capsules, up to a 2 month supply, 1,500mg total serving, provides 1,000mg L-lysine + 250mg quercetin + 200mg vitamin C and 50mg zinc picolinate.
  • Lysine is an important EAA that is necessary to have because we cannot produce it without the help of food or supplements, it may support antioxidant benefits for skin, gum, and immune health.
  • Non-GMO and free of gluten, wheat, soy, dairy, eggs, fish, shellfish, tree nuts, and peanuts. 3rd party lab tested for purity and potency.
No. 8
XYMOGEN L-Lysine 1000mg Capsules - Amino Acid Supplement to Support Synthesis of Collagen, Provides Balance to a High Intake of Arginine (90 Capsules)
  • Lysine is vital for normal growth and for the manufacture of collagen, a substance important for healthy skin, bones, tendons, and cartilage.*
  • Supplemental lysine may be appropriate for individuals on a high-arginine diet.*
  • Contains 500mg l-lysine per capsule.
  • Provides an essential amino acid.*
  • Formulated to Exclude: Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.
No. 9
THORNE Lysine - Essential Amino Acid for Skin Health, Energy Production, and Immune Function - 500 mg - 60 Capsules
  • Wound Healing: Supports the healing of unhealthy skin by promoting collagen formation*
  • Immune Health: Lysine’s nutritional support helps the body maintain its natural defenses and promotes healthy gum and lip tissues*
  • Skin And Bone Health: Promotes collagen formation for healthy and elastic skin, while also promoting calcium absorption for strong bones and teeth*
  • 3rd Party Contents Certified: This product has been third-party tested and certified to verify what's in the package matches what's on the label
  • Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners
SaleNo. 10
NOW L-lysine 500 mg, 250 Capsules
  • Non-GMO
  • GMP Certified
  • Essential Amino Acid
  • Supports Collagen Synthesis
  • A Dietary Supplement
SaleNo. 11
Solgar L-Lysine 1000 mg, 250 Tablets - Enhanced Absorption and Assimilation - Promotes Integrity of Skin and Lips - Collagen Support - Amino Acids - Non-GMO, Vegan, Gluten Free - 250 Servings
  • BENEFITS – L-Lysine is an amino acid that is used by the body for the production of collagen which is a protein that is used to promote the positive integrity of skin tissue as well as the lips.
  • EASY TO TAKE – The formulation of Solgar L-Lysine 1000mg provides the body with Free Form L-Lysine in order to promote optimal absorption and assimilation into the body’s systems. Health Concern: Hair, Skin, Nails
  • ESSENTIAL AMINO – L-Lysine is an essential amino acid that contributes to the body being able to support the health of skin tissue.
  • SUITABLE FOR VEGANS – All tablets are non-GMO and certified gluten free. They are also free of wheat, dairy, soy, yeast, sugar, sodium, artificial flavors, sweeteners, preservatives and colors.
No. 12
Bronson L-Lysine Extra Strength 1000 MG per Tablet High Potency, Immune Support & Supports Collagen Synthesis, Non-GMO, 100 Vegetarian Tablets
  • Extra Strength Vegetarian Tablets: Bronson L-Lysine Extra Strength provides a superior 1000 MG of high quality L-Lysine per vegetarian tablet. L-Lysine is an essential amino acid that is obtained through foods and supplementation.
  • Immune & Collagen Synthesis: L-Lysine helps to support a healthy immune system and promote collagen synthesis.* L-Lysine also helps to maintain healthy production of the amino acid L-Arginine.*
  • Superior Quality: Laboratory tested GMO-Free, Gluten-Free and Soy-Free. Bronson products are in-house tested and carefully manufactured by trained professionals in our state-of-the-art facility that is located in Hauppauge, New York.
  • cGMP Premium Standards: Every product manufactured by Bronson is put through a rigorous process to ensure purity, potency and integrity. Through our very own cGMP Certified New York Facility that complies with the most current regulations, we promise to deliver top-quality supplements that are consistently verified for quality and safety.
  • Trusted Since 1960: The pioneers of Bronson Vitamins were a group of pharmacists who witnessed the benefits of vitamins and mineral supplementation firsthand with their patients. Bronson Vitamins have been consistently mentioned by top medical professionals since our inception in 1960.
SaleNo. 13
BulkSupplements.com L-Lysine Powder - as L-Lysine HCl, Lysine Supplement, L-Lysine 1000mg - for Immune Support - Gluten Free, 1000mg per Serving, 500g (1.1 lbs) (Pack of 1)
  • Elevate Your General Health and Well-being: Tailored to support your overall health, our L-Lysine powder, or Lysine powder, is the perfect addition to any lifestyle. Packed with essential nutrients, they're designed to boost your general well-being, keeping you feeling your best day after day.
  • Versatility for all Lifestyles: Whether you're an athlete, a sprinter, or someone simply looking to stay active, our Lysine supplement, in L-Lysine 1000mg, seamlessly into your regimen, adaptable to a wide range of dietary needs and preferences.
  • Optimized in every Serving: Our L-Lysine HCl powder, or Lysine powder, is unflavored and free of unnecessary allergens, offering you a high-quality product that easily integrates with other supplements or your preferred shake or beverage.
  • Optimized in every Serving: Our L-Lysine HCl powder, or Lysine powder, is unflavored and free of unnecessary allergens, offering you a high-quality product that easily integrates with other supplements or your preferred shake or beverage.
  • Commitment to Excellence: Produced in a facility compliant with strict cGMP standards, our L-Lysine powder, or L-Lysine 1000mg powder, stands as a testament to our dedication to quality. You can trust in our product's consistency and excellence, batch after batch.
No. 14
Amazon Elements Lysine Complex with Vitamin C for Immune Health Support, Vegetarian, 65 Servings, 195 Count (Packaging may vary)
  • Lysine Complex with vitamin C, echinacea, and a variety of harvested ingredients, Supports Immune Health*
  • Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
  • 195 tablets, a 2 month supply (taken at the listed serving size of 3 tablets daily)
  • Vegetarian, gluten free, contains bee propolis; no artificial colors, flavors or chemical preservatives, contains bio-engineered ingredient
  • Good to Know: You may notice a slight to moderate smell that is similar to tree sap, the odor is coming from the Bee propolis
  • Made in a Good Manufacturing Practices (GMP) facility in the USA
  • Alexa voice shopping enabled: to place your next order, just say, "Alexa, reorder Amazon Elements Lysine Complex"
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
  • If you like NOW Supplements L-Lysine 1000mg, we invite you to try Amazon Elements Lysine Complex with Vitamin C
No. 15
Best Naturals L-Lysine 1000mg 180 Tablets - Double Strength Lysine for stronger immune health & cold sores
  • 3rd Party Lab Tested for Purity & Quality.
  • 1000 mg of L-Lysine HCL per Tablet - 180 Tablets per Bottle.
  • Non-GMO & Gluten-Free.
  • Proudly Made in USA, GMP Compliant, FDA Registered Facility.
  • No Artificial Color, Flavor, or Sweetener, No Preservatives, No Sugar, No Milk, No Corn, No Soy, No Egg, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.
SaleNo. 16
Horbäach L-Lysine 1000mg | 100 Coated Caplets | Free Form Dietary Supplement | Vegetarian, Non-GMO, and Gluten Free Formula
  • L-LYSINE: One of many essential amino acids- not produced by the body on its own
  • VEGETARIAN SUPPLEMENT: Delivers 1,000 mg of L-Lysine (HCl) per serving in coated caplets
  • EXPERTLY CRAFTED: Our professional formula is backed by our commitment to purity and potency
  • HORBAACH MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
  • NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Lactose, Artificial Flavor, Preservatives & Non-GMO
SaleNo. 17
Nutricost L-Lysine 1000mg Per Serving, 250 Servings, 500 Capsules - Gluten Free, Non-GMO, 500mg Per Capsule
  • 500mg of Premium L-Lysine Per Capsule, 1000mg Serving
  • 250 Servings (500 Capsules) of This Essential Amino Acid
  • Serving Size: 1-2 Capsules
  • Non-GMO, Gluten Free. Lid may be either blue or white
  • Made in a GMP Compliant, FDA Registered Facility.
No. 18
Nature's Bounty L-Lysine 1000 mg Tablets 60 ea (Pack of 2)
  • Vegetarian tablets
  • Helps maintain the health of your skin and lips
  • These statements have not been evaluated by the food and drug administration
  • Supports a healthy immune system
No. 19
SOLARAY L-Lysine, Free-Form 1000 mg, Essential Amino Acid Immune Support Supplement with Vitamin C 1,000 mg and Zinc 25 mg, Value Size, Lab Verified, 60-Day Guarantee, 60 Servings, 180 Tablets
  • Essential Amino: May help support healthy immune system, cognitive & gastrointestinal function
  • Super Lysine Immune Support – Our Lysine 1000mg and Vitamin C immune support supplement also includes 25 mg of Zinc and 10 mg of Vitamin B-6 and may be especially helpful for lip health.
  • Amino Acid Precursor – L-Lysine is also a precursor to other amino acids like L-Carnitine and is necessary for the synthesis and maintenance of structural proteins collagen and elastin.
  • Eco-Friendly: We use 100% PCR bottles made from plastic removed from oceans & landfills.
  • Trusted Brand – Made in our GMP-certified facility, tested in our own state-of-the-art lab in Utah to bring you the best possible quality, and always includes a 60-Day Money Back Guarantee.
No. 20
Quantum Health Super Lysine+ / Advanced Formula Lysine+ Immune Support with Vitamin C, Echinacea, Licorice, Propolis, Odorless Garlic (90 Tablets)
  • IMMUNITY BOOSTER - This comprehensive daily supplement is designed to help promote immune health and support daily lip care.
  • Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
  • GET AHEAD OF WHAT'S GETTING YOU BEHIND - Stress and immune challenges may get the best of you, but our special immune support formula can enable a fast recovery and help in prevention.
  • HERBAL IMMUNE SUPPORT - This complex balance of L-lysine, Vitamin C, Echinacea, Licorice, Propolis, and odorless Garlic help regulate arginine activity and immune systems in your body to maintain wellness.
  • EXTENDED BENEFITS - Along with immune support and oral care, propolis and licorice offer antioxidant support to combat free radicals in the bloodstream.
  • AWARD WINNING - Better Nutrition's Best of Supplements Award Winner, 2008; Taste for Life's Essentials Award Winner, 2013 & 2015.
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
  • Allergen information: soy_free

How to choose a good l lysine supplements

Does the idea of finding a fantastic l lysine supplements make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in l lysine supplements. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top l lysine supplements products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top l lysine supplements on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top l lysine supplements brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top l lysine supplements based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the l lysine supplements were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good l lysine supplements, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your l lysine supplements.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting l lysine supplements for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our l lysine supplements. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what l lysine supplements should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on l lysine supplements.