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The 8 Best mushroom supplement for immune support of 2025

Are you trying to find mushroom supplement for immune support among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling mushroom supplement for immune support on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 17 hours of research and did 56 mushroom supplement for immune support tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best mushroom supplement for immune support you can buy today

No. 1
Real Mushrooms 5 Defenders Capsules - Organic Mushroom Extract w/Chaga, Shiitake, Maitake, Turkey Tail, & Reishi - Mushroom Supplement for Focus, & Immune Support - Vegan, Non-GMO, 90 Caps
  • 5-in-1 Mushroom Complex: Our mushroom supplement is made from Chaga, Turkey Tail, Maitake, Shiitake, & Reishi mushrooms. It’s rich in beta-glucans, triterpenes, & nutrients.
  • Organic Mushroom Extract: Our mushroom capsules are only made from 100% mushrooms (fruiting bodies). It contains no grains, additives, or fillers.
  • Measured Beta-Glucans: Verified by 3rd-party labs, our organic mushroom supplement has >20% beta-glucans per capsule
  • How to Take: Adults take 2 capsules daily. You can also break a few capsules open and add them to your meal or drink. Our mushroom beta glucan supplements are gluten-free, non-GMO & vegan.
  • Mushrooms Made Real: At Real Mushrooms, we produce organic mushroom supplements that only contain 100% organic mushrooms, carefully sourced and processed for potency & efficacy. NPN: 80090823
No. 2
Host Defense MyCommunity Capsules - 17 Species Blend Mushroom Supplement for Immune Support - Herbal Aid with Lion's Mane, Reishi, Chaga, Cordyceps, Turkey Tail & More - 30 Capsules (15 Servings)*
  • Mushroom Supplement for Immune Support: This herbal mushroom supplement aids a healthy and balanced immune response with comprehensive support*
  • 17-Species Mushroom Supplement: Our herbal supplement is made with Lion's Mane, Reishi, Chaga, Cordyceps, Maitake, Royal Sun Blazei, Mesima and more for unique mushroom support*
  • About Host Defense: Host Defense Mushrooms was founded by renowned mycologist Paul Stamets; our mushroom mycelium is certified organic, non-GMO, gluten-free, and grown in the USA*
  • Powered by Mushroom Mycelium: Our organic mushroom mycelium is grown on organic brown rice substrate; third-party studies show that mushroom mycelium and fermented rice substrate support your health*
  • Mushroom Immunity Supplement: As a dietary supplement, take 2 vegan capsules once daily with food or on an empty stomach, or as recommended by your healthcare advisor*
SaleNo. 3
Genius Mushroom Supplement - Lions Mane, Cordyceps, Reishi - Brain Nootropic for Energy, Focus, Overall Wellness, & Immune Support - 90 Capsules
  • Nurture: Genius Mushrooms by The Genius Brand combines 3 of the most researched mycological species on the planet that help enhance clarity, system support function, and more. Genius Mushrooms are keto, paleo, and vegan friendly. Serving size - 3 capsules, 30 servings per container
  • System Booster: Step up your support with Reishi Mushroom Extract. Used for centuries, this booster is what you need to help keep yourself in check and dodge common ailments
  • Caffeine-Free Energy: Lion’s Mane provides boosting benefits to support focus, function, and mood. Cordyceps helps elevate your energy levels via ATP (natural energy) production, allowing for increased oxygen utilization and athletic endurance
  • How to Use: Take 3 capsules with 8 oz of water 20 minutes before a meal once a day. You may also take 1 capsule three times daily before meals, if preferred
  • Supplement Smarter: Genius Brand supplements are a rejection of backwards industry dogma that misled generations of enthusiasts. For us, innovation and science-backed ingredients come first. Whether you’re a pro athlete, stay-at-home parent, retiree, or anything in between, our products can be of benefit to you. We’re all humans, and we are in this together
No. 4
FreshCap Ultimate Mushroom Complex - Lions Mane, Reishi, Cordyceps, Chaga, Turkey Tail, Maitake - Immune Support & Nootropic Brain Supplements for Immunity, Energy, Memory & Focus (60 Capsules)
  • Ultimate Immune Support Supplement: FreshCap's Ultimate Mushroom Complex delivers all the amazing benefits of mushrooms including enhanced immunity, focus and energy. With 6 of the most popular and researched mushroom species in the world (Lion's Mane, Reishi, Cordyceps, Chaga, Turkey Tail & Maitake) it's a powerful, potent, and effective mushroom supplement made from organic whole fruiting bodies and thoroughly extracted for bio-active compounds so you get only the good stuff.
  • Organic, Powerful & Active Compound Verified: Our mushroom supplements are CCOF Certified Organic, Non-GMO, Gluten Free, Vegan and Paleo friendly. All supplements are 3rd party tested and scientifically verified to contain greater than 29% beta-glucans, which are the beneficial compounds you’re looking for, and to guarantee purity and quality.
  • No Fillers, Stop the Grain: We use only whole mushroom fruiting bodies with no filler, mycelium, extra starch or grains. Many of our competitors use mycelium-based products that are grown on grain, which means you are buying product that has filler like brown rice or oats (even if they claim otherwise). It is nearly impossible to separate mycelium from the grain base. Make sure to look for whole fruiting body based products.
  • Easy To Use: Each bottle contains 60 capsules and is a 1 month supply at the recommended serving size (2 capsules/day). Our capsules are easy to use, and can be taken with you anywhere you go. Mushroom supplements are a great addition to all of your existing supplements (e.g. multi-vitamins) and FreshCap's mushroom powder can be a great addition to make mushroom coffee or enhance your smoothies, shakes and tea.
  • Trust the Experts: We want you to feel amazing and be happy. Get what you’d expect from a premium mushroom supplement.
No. 5
Host Defense Stamets 7-7 Species Blend - Mushroom Supplement for Immune Support - Includes Royal Sun Blazei, Cordyceps, Reishi, Maitake, Lion's Mane, Chaga & Mesima - 120 Capsules (60 Servings)*
3,611 Consomer Reviews
Host Defense Stamets 7-7 Species Blend - Mushroom Supplement for Immune Support - Includes Royal Sun Blazei, Cordyceps, Reishi, Maitake, Lion's Mane, Chaga & Mesima - 120 Capsules (60 Servings)*
  • Mushroom Supplement for Daily Immune Support: This daily mushroom supplement supports immune health as well as respiratory, circulatory, cellular, and lymphatic health*
  • 7-Species Mushroom Supplement: Our herbal supplement is made with Lion's Mane, Reishi, Chaga, Cordyceps, Maitake, Royal Sun Blazei, and Mesima for daily immune support*
  • About Host Defense: Host Defense Mushrooms was founded by renowned mycologist Paul Stamets; our mushroom mycelium is certified organic, non-GMO, gluten-free, and grown in the USA*
  • Powered by Mushroom Mycelium: Our organic mushroom mycelium is grown on organic brown rice substrate; third-party studies show that mushroom mycelium and fermented rice substrate support your health*
  • Stamets 7 Mushroom Supplement: As a dietary supplement, take 2 vegan capsules once daily with food or on an empty stomach, or as recommended by your healthcare advisor
No. 6
Host Defense MyCommunity Extract - 17 Species Blend Mushroom Supplement for Immune Support - Extract with Lion's Mane, Reishi, Chaga, Cordyceps, Turkey Tail & More - 1 fl oz (30 Servings)*
  • Mushroom Supplement for Immune Support: This herbal mushroom supplement aids a healthy and balanced immune response with comprehensive support*
  • 17-Species Mushroom Supplement: Our herbal supplement is made with Lion's Mane, Reishi, Chaga, Cordyceps, Maitake, Royal Sun Blazei, Mesima and more for unique mushroom support*
  • About Host Defense: Host Defense Mushrooms was founded by renowned mycologist Paul Stamets; our mushroom mycelium is certified organic, non-GMO, gluten-free, and grown in the USA*
  • Powered by Mushroom Mycelium: Our organic mushroom mycelium is grown on organic brown rice substrate; third-party studies show that mushroom mycelium and fermented rice substrate support your health*
  • Mushroom Immunity Supplement: As a dietary supplement, take 1 full dropper bulb squeeze twice per day with food or on an empty stomach, or as recommended by your healthcare advisor*
No. 7
Host Defense Stamets 7 Mushroom Powder - 7 Species Blend - Mushroom Supplement for Immune Support with Royal Sun Blazei, Cordyceps, Reishi, Maitake, Lion's Mane, Chaga & Mesima - 3.5 oz (66 Servings)*
  • Mushroom Supplement for Daily Immune Support: This daily mushroom supplement supports immune health as well as respiratory, circulatory, cellular, and lymphatic health*
  • 7-Species Mushroom Supplement: Our herbal supplement is made with Lion's Mane, Reishi, Chaga, Cordyceps, Maitake, Royal Sun Blazei, and Mesima for daily immune support*
  • About Host Defense: Host Defense Mushrooms was founded by renowned mycologist Paul Stamets; our mushroom mycelium is certified organic, non-GMO, gluten-free, and grown in the USA*
  • Powered by Mushroom Mycelium: Our organic mushroom mycelium is grown on organic brown rice substrate; third-party studies show that mushroom mycelium and fermented rice substrate support your health*
  • Stamets 7 Mushroom Supplement: As a dietary supplement, take a 1/2 teaspoon 1–3 times daily with food or on an empty stomach, or as recommended by your healthcare advisor
No. 8
Host Defense MyCommunity Powder - 17 Species Blend Mushroom Supplement for Immune Support - Extract with Lion's Mane, Reishi, Chaga, Cordyceps, Turkey Tail & More - 100g (66 Servings)*
104 Consomer Reviews
Host Defense MyCommunity Powder - 17 Species Blend Mushroom Supplement for Immune Support - Extract with Lion's Mane, Reishi, Chaga, Cordyceps, Turkey Tail & More - 100g (66 Servings)*
  • Mushroom Supplement for Immune Support: This herbal mushroom supplement aids a healthy and balanced immune response with comprehensive support*
  • 17-Species Mushroom Supplement: Our herbal supplement is made with Lion's Mane, Reishi, Chaga, Cordyceps, Maitake, Royal Sun Blazei, Mesima and more for unique mushroom support*
  • About Host Defense: Host Defense Mushrooms was founded by renowned mycologist Paul Stamets; our mushroom mycelium is certified organic, non-GMO, gluten-free, and grown in the USA*
  • Powered by Mushroom Mycelium: Our organic mushroom mycelium is grown on organic brown rice substrate; third-party studies show that mushroom mycelium and fermented rice substrate support your health*
  • Mushroom Immunity Supplement: As a dietary supplement, take 1/2 teaspoon 1–3 times per day with food or on an empty stomach, or as recommended by your healthcare advisor*
No. 9
Youtheory Immune+ Daily Wellness - Vegetarian Immune Support Supplement with Vitamin C, Vitamin D3 & Zinc* - Mushroom Supplement with Turkey Tail, Cordyceps & Reishi - 60 Vegetarian Caps
  • Immune Support Supplement: Immune Plus Daily Wellness incorporates vitamin C, vitamin D3, and zinc for immunity support*
  • Mushroom Supplement: Our mushroom blend provides a combined 1,000 mg of six different organic mushrooms, including Cordyceps, Turkey Tail, Reishi, Maitake, Shiitake, and Royal Sun Agaricus
  • Clinically Studied: This immune system supplement has been studied in 12 gold-standard clinical studies
  • Vegetarian Dietary Supplement: Our vitamin C supplement is vegetarian, dairy-free, soy-free, and gluten-free, making it accessible to many dietary restrictions
  • The Youtheory Promise: Everything we do is based on a dedication to build pure and effective supplements to support our mission to inspire wellness in all
No. 10
MegaFood Superfood Mushroom Immune Support - Maitake Mushroom Supplement with Elderberry & Holy Basil to Help Support a Healthy Immune System - Doctor Formulated, Vegan - 60 Capsules, 30 Servings
  • PLANT-POWERED IMMUNE SUPPORT SUPPLEMENT: Maitake mushroom pairs with Elderberry and Holy Basil – an adaptogenic ingredient that supports the immune system and overall wellness
  • DOCTOR FORMULATED WITH GUARANTEED BETA GLUCANS: 45 mg of beta glucans per serving; This mushroom supplement is made with 100% fruiting bodies from Maitake mushrooms; No mycelium or grain fillers
  • GREENHOUSE GROWN: Our mushrooms are grown on natural substrates with environmental conditions of fresh air, ambient temperatures, and humidity to align with our rigorous internal quality standards
  • TAKE ANY TIME OF DAY: Adults take two of these Maitake mushroom, Holy Basil & Elderberry capsules any time of day with food and a beverage; Bottle contains 60 capsules for 30 servings
  • FREE FROM COMPROMISE: Gluten-free, Vegan, Non-GMO, tested for 150 chemical substances, third party tested for heavy metals, and made without milk, eggs, peanuts, tree nuts, soy, wheat, fish, shellfish, and sesame

How to choose a good mushroom supplement for immune support

Does the idea of finding a fantastic mushroom supplement for immune support make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in mushroom supplement for immune support. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top mushroom supplement for immune support products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top mushroom supplement for immune support on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top mushroom supplement for immune support brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top mushroom supplement for immune support based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the mushroom supplement for immune support were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good mushroom supplement for immune support, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your mushroom supplement for immune support.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting mushroom supplement for immune support for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our mushroom supplement for immune support. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what mushroom supplement for immune support should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on mushroom supplement for immune support.