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The 8 Best nonaspirin pain relievers of 2024

Are you trying to find nonaspirin pain relievers among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling nonaspirin pain relievers on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 19 hours of research and did 82 nonaspirin pain relievers tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best nonaspirin pain relievers you can buy today

SaleNo. 1
Geri-Care Acetaminophen 325 mg, Regular Strength, Non-Aspirin Pain Reliever/Fever Reducer, 1000 Tablets
  • Acetaminophen 325 mg
  • Non-Aspirin
  • Regular Strength
  • Pain Reliever
  • Fever Reducer
No. 2
ValuMeds Extra Strength Headache Relief Caplets (300-Count) | Nonsteroidal Anti-Inflammatory Pain Reliever | Migraine Relief, Arthritis, Muscles, Joints
7,677 Consomer Reviews
ValuMeds Extra Strength Headache Relief Caplets (300-Count) | Nonsteroidal Anti-Inflammatory Pain Reliever | Migraine Relief, Arthritis, Muscles, Joints
  • Powerful Migraine Relief: Valumeds Extra Strength Headache Relief offers fast and effective pain relief, providing potent relief from migraines and headaches. With each count, you'll have a reliable solution to combat the pain and discomfort that often accompanies these conditions.
  • Trusted Brand Quality: Comparable to Tylenol and Excedrin, our Acetaminophen formula delivers effective relief. Trust in the quality and reliability of our trusted brand, backed by years of experience in providing pain relief medicine to millions of satisfied customers.
  • Versatile Pain Management: Our medication isn't limited to migraines alone; it also effectively addresses other types of pain. From arthritis pain to muscle tension, our extended-release formula ensures long-lasting relief throughout the day.
  • Travel Size Packaging: Each bottle contains 300 caplets easy and on-the-go use. Whether you're at home, work, or traveling, you'll have immediate access to pain relief whenever you need it.
  • Suitable for Adults: Valumeds Extra Strength Headache Relief is designed for adults seeking fast and effective pain relief. With our Acetaminophen pills, you can bid farewell to headaches, migraines, and various other types of pain, allowing you to get back to your daily activities with ease.
No. 3
Quality Choice Extra Strength Pain Relief PM, Pain Reliever and Nighttime Sleep Aid, Acetaminophen 500 mg & Diphenhydramine HCI 25 mg (Sleep Aid), 50 Count Package of Caplets
  • Quality Choice Extra Strength Pain Relief PM 50 count bottle of Nighttime pain relief Compares to the Active Ingredients in Extra Strength Tylenol PM and is a Non Habit Forming sleep aid that provides relief from minor pain and helps you fall asleep easier
  • Extra Strength Pain Relief PM provides Comfort and relief from pain through 500 mg of Acetaminophen and aids in falling asleep faster with 25 mg of Diphenhydramine HCI a Non Habit forming Nighttime sleep Aid
  • Extra Strength Pain Relief and sleep aid that can be used to provide temporary relief of occasional headaches and minor aches and pains that accompany sleeplessness
  • Taking this Medicine Helps you Fall Asleep easier and stay Asleep longer without waking up from nighttime headaches or pains.
  • Compares to the name brand Nighttime Pain medications that use 500 mg of Acetaminophen to provide the relief you desire and the sleep you need.
No. 4
Quality Choice, Extra Strength, Non Aspirin Pain Relief, Acetaminophen 500 MG, Pain Reliever & Fever Reducer, Rapid Release Gelcaps, 50 Count Package
  • Quality Choice Extra Strenth, Non-Aspirin Pain Relief Compares to the active ingredient in Extra Strength TYLENOL Rapid Release Gels caps and comes in a 50 count package
  • Extra Strength Pain Relief by Quality Choice contains 500 mg of Acetaminophen in Rapid Release Gelcaps for a quick and efficient delivery of pain relief when you need it most.
  • Extra Strength Non Aspirin Pain Relief is used to temporarily provide pain relief from Headaches, backaches, Minor Pain of Arthritis, Muscular aches, toothaches, premenstrual and menstrual cramps and more.
  • 500mg of Acetaminophen also provides relief from fever and other common cold symptoms when taken as recommended
  • Package contains 50 Geltabs
No. 5
Rite Aid Extra Strength 500 mg Acetaminophen Pain Relief, Rapid Release Gelcaps - 225 Count | Pain Reliever, Joint Pain Relief | Muscle Pain Relief | Arthritis Pain Relief | Back Pain Relief Products
  • PAIN RELIEVER & FEVER REDUCER: Rite Aid Extra Strength Acetaminophen Rapid Release Gelcaps reduce fevers temporarily while offering minor headache relief, relief from muscular and body aches, and pains often associated with arthritis and/or joint pain.
  • EXTRA STRENGTH: Compare Rite Aid’s Extra Strength Acetaminophen Rapid Release Gels to the active ingredient in top brands. Get all the benefits of an effective pain reliever with Rite Aid Acetaminophen— designed for fast-acting pain relief.
  • EASY-OPEN BOTTLE: When you need pain relief, you want a quick and easy bottle to open. Rite Aid Acetaminophen comes in an easy-open bottle that’s perfect for adults with arthritis pain, and makes these gelcaps ideal for use both at home and on-the-go.
  • NO ASPIRIN: Each gelcap contains 500 mg of pain relieving, fever reducing acetaminophen without any aspirin. This aspirin-free arthritis pain relief, back pain relief, joint pain relief, and muscle pain relief medicine is formulated for easy swallowing.
  • TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the health and wellness of our communities and provide our customers with the best products, services, and advice.
No. 6
Fever
  • Audio CD – Audiobook
  • KES-KES MUSIC LABEL GROUP (Publisher)
No. 7
TIME-CAP LABS, INC. Timely Acetaminophen PM - Extra Strength PM - 400 Count - Compared to Tylenol PM Extra Strength - Pain Relief PM for a Good Night Sleep - Made in USA
  • Reliable Relief - Our acetaminophen 500mg pm is formulated carefully with maximum strength to give you faster and more reliable pain relief. Whether it’s headaches or other types of minor aches and pain, fight the pain away and rest better with Timely, proudly made in the USA.
  • Banish Pain and Sleep Well - Get a deep and restful sleep during the night so you can face the next day feeling fresh. Our pm pain relief contains acetaminophen pm 500mg extra strength and Diphenhydramine HCl 25mg to help you soothe your body and mind, giving it much-needed relaxation.
  • Safe for Regular Use - Our pm headache relief is non-habit forming when used as directed, so you can take a dose with confidence knowing you don’t have to worry about dependence. Be sure to consult with your healthcare professional for details and best practices
  • National Brand Equivalency - We believe that pm pain caplets should be affordable to everyone at a fair price. That’s why Timely offers National Brand Equivalency, meaning our acetaminophen provides the same efficacy as national brands at a lower cost.
  • A Must-Have in Every Medicine Cabinet - Adults and children 12 years and over can find easy sleep relief in this bottle of this acetaminophen pm. Each bottle comes with 400 caplets to provide long-term relief for the family
SaleNo. 8
GoodSense Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125 mg Tablets, Pain Reliever for Headache Relief, Arthritis Pain Relief and More, 144 Count
  • ACTIVE INGREDIENTS: The active ingredients are acetaminophen 250 mg - a pain reliever and ibuprofen 125 mg - a nonsteroidal anti-inflammatory drug (NSAID) and pain reliever; compare to the active ingredients of Advil Dual Action with Acetaminophen
  • POWERFUL PAIN FIGHTING RELIEF: Take these pain pills for up to 8 hours of powerful pain relief from minor aches and pains due to headache, toothache, backache, menstrual cramps and muscular aches and minor arthritis pain
  • DOUBLE DOWN ON PAIN RELIEF: These pain relief pills contain two medicines that help fight pain: acetaminophen 250 mg and ibuprofen (NSAID) 125 mg; provides arthritis pain relief, headache relief and more
  • PAIN RELIEF FOR ADULTS: This pain medicine is for adults and children 12 years and over; children under 12 years: ask a doctor
  • GLUTEN FREE: GoodSense Dual Action tablets are gluten free
No. 10
A+Health Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125mg Pain Reliever Caplets, 216 Count
  • ACTIVE INGREDIENTS: A+ Health Dual Action Pain Reliever tablets contain 250 mg of Acetaminophen and 125 mg of Ibuprofen. Compare to the active ingredients in the National Brand.
  • UP TO 8 HOURS OF PAIN RELIEF: Provides temporary pain relief due to headache, backache, muscular aches, toothache, menstrual cramps and minor pain of arthritis.
  • DUAL ACTION PAIN RELIEVER: Contains 2 medicines for pain fighting relief: Acetaminophen 250 mg and Ibuprofen 125 mg in one caplet.
  • DIRECTIONS: Adults and children 12 years and over: take 2 caplets every 8 hours while symptoms persist. Do not take more than 6 caplets in 24 hours, unless directed by a doctor. Children under 12 years: Ask a doctor. Please see packaging for full Drug Fact information.
  • DON’T LET PAIN GET IN YOUR WAY: You can find relief with A+ Health Dual Action Pain Reliever. Each bottle contains 216 capsule-shaped tablets.
No. 11
Medique @ Home 70333 APAP Non-Aspirin Tablets, 100 Count(Pack of 2)
  • Gentler on the stomach than aspirin
  • Active ingredient Acetaminophen 325mg
  • 100 Count tablets,, 2 pills per packet
  • Helps provide temporary relief from headaches, muscular aches, pains and fevers
SaleNo. 12
Amazon Basic Care Pain Relief, Acetaminophen Tablets 325 mg, Regular Strength, Pain Reliever and Fever Reducer, 100 Count
  • ACTIVE INGREDIENT: The active ingredient is acetaminophen 325 mg, a pain reliever and fever reducer; compare to the active ingredient of Regular Strength Tylenol Tablets
  • PAIN RELIEVER AND FEVER REDUCER: These tablets temporarily relieve minor aches and pains due to headache, muscular aches, backache, minor pain of arthritis, the common cold, toothache, premenstrual and menstrual cramps, and temporarily reduce fever
  • REGULAR STRENGTH: Amazon Basic Care Pain Relief, Acetaminophen Tablets 325 mg are a regular strength remedy to help relieve minor aches, pains and fever
  • FOR ADULTS AND CHILDREN: A pain reliever and fever reducer for adults and children ages 6 years and over
  • GLUTEN FREE: This product is gluten free and contains no aspirin
No. 13
Excedrin Head Care Proactive Health Dietary Supplement - 110 Count and Head Care Replenish Plus Focus Drink Mix from 24 Packets Convenience Pack
  • One convenience pack of 110 tablets of Head Care Proactive Health Dietary Supplement and 24 packets of Head Care Replenish Plus Focus Drink Mix
  • Proactive Health head care dietary supplement product helps you support daily head health (1)
  • Head Care Replenish Plus Focus drink mix helps you feel your best after occasional head discomfort
  • Proactive Health product contains Magnesium, Riboflavin, Vitamin B6, Folic Acid and Vitamin B12
  • Head Care Replenish +Focus is a drink mix contains Caffeine, L-theanine, Electrolytes and Ginger
No. 14
Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 100 Coated Caplets
  • One pack of 100 Advil Pain Reliever and Fever Reducer coated caplets, with ibuprofen 200mg for pain relief
  • Advil ibuprofen pain reliever provides powerful relief, and by 2022, new packaging will feature 20% less plastic to keep nearly 500,000 pounds of plastic out of landfills
  • Headache medicine, back pain medicine and joint or minor arthritis pain reliever that also provides menstrual pain relief, as well as relief of muscle aches or aches and pains from the common cold
  • Coated Advil caplets are easy to swallow pain relievers, providing relief that lasts for up to 6 hours
  • Headache, minor arthritis pain, menstrual pain and back pain medication for adults and children 12 years and older
  • Take these 200mg ibuprofen caplets as directed, taking one tablet every 4 to 6 hours while symptoms persist, or two caplets if pain or fever does not respond to one tablet
  • HSA and FSA eligible product
  • HSA and FSA eligible product
No. 15
Balkan Fever
  • Audio CD – Audiobook
  • Wagram (Publisher)
No. 16
GeriCare Extra Strength Pain Relief Acetaminophen Tablets - Non Asprin
497 Consomer Reviews
SaleNo. 17
GoodSense Extra Strength Acetaminophen Caplets 500 mg, Pain Reliever and Fever Reducer, 100 Count, 50 Pouches of 2 Caplets
  • ACTIVE INGREDIENT: GoodSense Extra Strength Acetaminophen Caplets 500 mg's active ingredient is acetaminophen 500 mg. Compare to the active ingredient of Extra Strength Tylenol Caplets.
  • PAIN RELIEVER AND FEVER REDUCER: Temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps. Also temporarily reduces fever.
  • EASY TO SWALLOW: Count on these easy-to-swallow caplets for fast-acting headache and fever relief. GoodSense Extra Strength Acetaminophen Caplets 500 mg may be used as a pain reliever and fever reducer for adults and children 12 years and over.
  • EXTRA STRENGTH PAIN RELIEF: When pain has you in its grips, even small tasks can be tough. GoodSense Extra Strength Acetaminophen Caplets 500 mg provides strong, fast pain relief in convenient travel size packs for when you're on the go.
  • ASPIRIN AND CAFFEINE FREE. GoodSense Extra Strength Acetaminophen Caplets 500 mg provides the pain relief and fever reduction you need and is safe when taken as directed. This product is gluten free.
SaleNo. 18
Amazon Basic Care Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125 mg Tablets, Pain Reliever for Headache Relief, Arthritis Pain Relief and More, 216 Count
  • ACTIVE INGREDIENTS: The active ingredients are acetaminophen 250 mg - a pain reliever, and ibuprofen 125 mg - a nonsteroidal anti-inflammatory drug (NSAID) and pain reliever; compare to the active ingredients of Advil Dual Action with Acetaminophen
  • POWERFUL PAIN FIGHTING RELIEF: Take these pain pills for up to 8 hours of powerful pain relief from minor aches and pains due to headache, toothache, backache, menstrual cramps and muscular aches and minor arthritis pain
  • DOUBLE DOWN ON PAIN RELIEF: These pain relief pills contain two medicines that help fight pain: acetaminophen 250 mg and ibuprofen (NSAID) 125 mg; provides arthritis pain relief, headache relief and more
  • PAIN RELIEF FOR ADULTS: This pain medicine is for adults and children 12 years and over; children under 12 years: ask a doctor
  • GLUTEN FREE: Dual Action tablets are gluten free
No. 19
TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 225 Caplets - Extended Release - Compared to Tylenol 8 HR Arthritis Pain Active Ingredient - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief
  • Relieve Minor Aches and Pains ... Toothache? Backache? Acetaminophen relieves minor aches and pains due to headache, backache, toothache, the common cold, minor pain of arthritis, muscular aches, and premenstrual and menstrual cramps.
  • Let That Fever Subside ... Dealing with a fever? Acetaminophen temporarily reduces fever, and relieves those aches and pains caused by minor pain of arthritis.
  • Highest Quality at Great Prices ... These OTC medications & treatments provide the same efficacy as your usual branded acetaminophen extended release. After all, your health shouldn't come at a cost.
  • One in Every Medicine Cabinet ... Make sure every medicine cabinet and first-aid kit has these great pain tablets. 400 caplets are plenty enough to provide long-term relief for the family.
  • An Easy Way to Be Pain-Free … Find prolonged relief in a bottle of this Arthritis Pain Reliever Acetaminophen 650mg. Take as directed on the bottle.
No. 20
Rite Aid Acetaminophen 650mg Arthritis Extended Release Caplets - 225 Count
  • PAIN & FEVER REDUCER: Rite Aid Acetaminophen tablets reduce fevers temporarily while offering minor headache relief, relief from muscular and body aches, often associated with arthritis and/or joint pain.
  • NO ASPRIN: Each tablet contains 650 mg of ache relieving, fever reducing acetaminophen without any aspirin. This aspirin-free arthritis relief, back relief, joint relief, and muscle relief medicine is formulated without aspirin.
  • EASY TO SWALLOW CAPLETS: Acetaminophen caplets’ shape make them easier to swallow. Rite Aid Acetaminophen’s easy-to-swallow caplet makes these menstrual relief, joint/muscle relief, and migraine relief pills ideal for use at home or on-the-go.
  • TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the health and wellness of our communities and provide our customers with the best products, services, and advice.

How to choose a good nonaspirin pain relievers

Does the idea of finding a fantastic nonaspirin pain relievers make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in nonaspirin pain relievers. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top nonaspirin pain relievers products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top nonaspirin pain relievers on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top nonaspirin pain relievers brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top nonaspirin pain relievers based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the nonaspirin pain relievers were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good nonaspirin pain relievers, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your nonaspirin pain relievers.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting nonaspirin pain relievers for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our nonaspirin pain relievers. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what nonaspirin pain relievers should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on nonaspirin pain relievers.