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The 8 Best oral pain relief medications of 2024

Are you trying to find oral pain relief medications among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling oral pain relief medications on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 16 hours of research and did 30 oral pain relief medications tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best oral pain relief medications you can buy today

SaleNo. 1
Orajel 3X for Toothache & Gum Pain: Maximum Gel Tube 0.42oz - From #1 Oral Pain Relief Brand - Orajel for Instant Pain Relief
  • INSTANT PAIN RELIEF: Instant pain relief with Orajel’s maximum strength formula to help relieve pain of the tooth and gums with 20% benzocaine
  • KILLS HARMFUL BACTERIA: Unique formula is designed to help kill harmful bacteria in the mouth, and can help to prevent infections
  • COOLING RELIEF: To help relieve gum irritation, Orajel toothache gel contains cooling relief
  • EASY OPEN: Now with a Ready-Open Tube Tip for easy access to the relief you need. A convenient remedy for use at home or on the go
  • From the Oral Pain Reliever Brand for Adults
No. 2
Rite Aid Maximum Strength Liquid Anesthetic Oral Pain Relief - .5 fl oz, Benzocaine 20% | Pain Relief Medications & Treatments | Canker Sore and Tooth Pain Relief for Adults | Mouth Sores Treatment
  • MOUTH SORE TREATMENT: Rite Aid Max Strength Oral Liquid Anesthetic Benzocaine 20% pain relieving liquid temporarily relieves pain associated with toothaches, sore gums, mouth sores, canker sores, dentures/braces, cheek bites, and minor dental procedures.
  • FAST-ACTING PAIN RELIEF: Rite Aid offers instant relief from pain associated with toothaches, gum pain, canker sores, and dentures/braces. Compare Rite Aid to the leading national brand and get the same reliable mouth pain relief you can count on.
  • MAXIMUM STRENGTH: Formulated with 20% Benzocaine, Rite Aid Maximum Strength Liquid Anesthetic Oral Pain Relief offers the maximum amount of pain relief and aims to temporarily relief the mouth and tooth pain that ails you, so you can live pain free.
  • ADULTS AND CHILDREN 2 YEARS AND UP: Apply to affected area using applicator tip. Use up to 4 times daily or as directed by a doctor. Children under 12 years of age should be supervised in the use of this product. Children under 2 years of age do not use.
  • TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the health and wellness of our communities and provide our customers with the best products, services, and advice.
SaleNo. 3
Anbesol Maximum Strength Oral Pain Relief Gel, Instant Pain Relief For Toothache Pain, Canker Sores, Sore Gums, Mouth Sores, Denture Pain, and Aligner Pain, ADA Accepted, 0.33 oz (packaging may vary)
  • INSTANT PAIN RELIEF: Instant oral pain relief for mouth and gum irritation due to toothaches, canker sores, sore gums, denture pain, and minor dental procedures. Use with dentures to relieve discomfort.
  • MAXIMUM STRENGTH: Instant relief that takes you from ouch to ahhh! So, oral pain doesn’t hold you back. Formulated with 20% Benzocaine to offer maximum strength pain relief and instantly soothe mouth pain and dental irritation
  • EASY TO USE: Cut the Tube Tip for easy access to the oral pain relief you need; Adults and children 2 years and over. Not for use in children under 2 years of age.
  • ACTIVE INGREDIENT: Benzocaine 20% Oral anesthetic for pain relief.
SaleNo. 4
DenTek Instant Oral Pain Relief Maximum Strength Kit for Toothaches | 50 Count
  • DenTek Instant Pain Relief, Advanced Kit gives instant and precise relief from oral pain and toothaches
  • Ergonomic handle to reach any area of the mouth gives simple, no-fingers no-mess, relief
  • Fresh Mint flavored Benzocaine relieves tooth pain, sore gums and mouth sores
  • Maximum strength pain reliever
  • 50 disposable applicators easily slide into the handle for a sanitary way to relieve tooth pain
  • DenTek Instant Pain Relief, Advanced Kit includes 1 bottle of Benzocaine (20%) 3.5 mL, 50 count disposable applicators, applicator handle and carrying case
No. 6
Orajel, Instant Pain Relief Gel, Severe Toothache - 0.25 oz, 2 Pack
  • It works immediately to deliver pain medication and lasts for hours, cooling and soothing the painful area.
No. 7
Rite Aid Toothache Relief Oral Gel - 0.42 oz
  • MOUTH SORE TREATMENT: Rite Aid Toothache & Gum Reliever Benzocaine 20% pain relieving liquid temporarily relieves pain associated with toothaches, sore gums, mouth sores, canker sores, dentures/braces, cheek bites, and minor dental procedures.
  • 3X MEDICATED FAST-ACTING PAIN RELIEF: Rite Aid offers instant relief thanks to 3X medicated formula with Benzocaine, Astringent, and Menthol. Compare Rite Aid tooth pain relief to the leading national brand and get the same reliable mouth pain relief.
  • PAIN RELIEVER / ASTRINGENT: Formulated with 20% Benzocaine, Astringent, and Menthol, Rite Aid Toothache & Gum Reliever offers the maximum amount of nerve pain relief and aims to temporarily relieve the mouth and tooth pain that ails you.
  • ADULTS AND CHILDREN 2 YEARS AND UP: Apply to affected area up to 4 times daily or as directed by a dentist or doctor. Children under 12 years of age should be supervised in the use of this product. Children under 2 years of age do not use.
  • TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the health and wellness of our communities and provide our customers with the best products, services, and advice.
No. 9
Rite Aid Severe Toothache and Gum Relief - 0.25 oz
  • MOUTH SORE TREATMENT: Rite Aid Severe Toothache & Gum Relief Benzocaine 20% pain relieving gel temporarily relieves pain associated with toothaches, sore gums, mouth sores, canker sores, dentures/braces, cheek bites, and minor dental procedures.
  • FAST-ACTING PAIN RELIEF: Rite Aid offers instant relief from pain associated with toothaches, gum pain, canker sores, and dentures/braces. Compare Rite Aid to the leading national brand and get the same reliable mouth pain relief you can count on.
  • FOR SEVERE PAIN: Formulated with 20% Benzocaine, Menthol 0.5%, and Zinc Chloride 0.15%, Rite Aid Rite Aid Severe Toothache & Gum Relief offers the maximum amount of pain relief and aims to temporarily relief the mouth and tooth pain that ails you.
  • ADULTS AND CHILDREN 2 YEARS AND UP: Apply to affected area using applicator tip. Use up to 4 times daily or as directed by a doctor. Children under 12 years of age should be supervised in the use of this product. Children under 2 years of age do not use.
  • TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the health and wellness of our communities and provide our customers with the best products, services, and advice.
SaleNo. 10
Motrin Dual Action with Tylenol, Dual Action Pain Reliever with Ibuprofen & Acetaminophen, Two Medicines for Minor Aches & Pains, Ibuprofen (NSAID) 125 mg & Acetaminophen 250 mg, 80 ct
  • 80-count bottle of Motrin Dual Action with Tylenol, dual action ibuprofen (NSAID) and acetaminophen, pain reliever with two medicines for minor aches and pains
  • The dual action Motrin with Tylenol pain relief tablets each contain 250 mg acetaminophen plus 125 mg ibuprofen (nonsteroidal anti-inflammatory drug) to temporarily relieve minor aches and pains
  • Use this 2-in-1 pain reliever medicine to temporarily relieve minor aches and pains due to headache, toothache, backache, menstrual pains, period cramps, muscle aches and minor pain caused by arthritis
  • Motrin Dual Action with Tylenol pain relief medicine is intended for adults and children 12 years of age and older with minor aches and pains. Take two pain relief tablets every 8 hours while symptoms persist
  • Motrin Dual Action with Tylenol contains acetaminophen. Severe liver damage may occur if you take with other drugs containing acetaminophen.
SaleNo. 11
Percogesic Original Pain Relief | Aspirin Free Fast Acting Relief | 90 Coated Caplets
  • Percogesic Original Strength Pain Relief provides prescription free relief from common aches and pains from headaches, menstrual cramps, and more
  • Contains Acetaminophen and Diphenhydramine HCL, for aspirin-free relief you can trust
  • Effective oral analgesic with enhanced pain relief; easy to swallow coated tablets
  • Take 2 tablets every 4 hours while symptoms persist; safe for adults and children 12 years and over
  • Pharmacist Recommended; FSA/HSA eligible item in the USA
SaleNo. 12
Orajel 4X for Toothache & Gum Pain: Severe Cream Tube 0.33oz- From Oral Pain Relief Brand
  • INSTANT PAIN RELIEF: Instant pain relief with Orajel’s unique 4X clinical strength formula to help relieve pain of the tooth and gums
  • 4X ACTIVE INGREDIENTS: With 4 active ingredients, Orajel Cream provides fast acting and maximum strength relief when you need it most
  • KILLS HARMFUL BACTERIA: Unique formula is designed to help kill harmful bacteria in the mouth, and can help to prevent infections
  • COOLING RELIEF: To help relieve gum irritation, Orajel 4X cream contains cooling relief
  • EASY OPEN: Now with a Ready-Open Tube Tip for easy access to the relief you need. A convenient remedy for use at home or on the go.
SaleNo. 13
Anbesol Maximum Strength Oral Anesthetic Liquid - 0.41 fl oz (Packaging May Vary)
  • Instant Oral Pain Relief: Anbesol Maximum Strength Liquid for mouth pain, including toothache pain, canker sores, sore gums, mouth sores, denture pain, braces, retainer and aligner pain, and minor dental procedures
  • OW to WOW! Instantly: Formulated with the active ingredient Benzocaine, an oral pain reliever, and numbs instantly to temporarily relieve toothaches, gum pain, canker sores and aligner pain.
  • Liquid Formula: Anbesol Liquid Formula goes on clear and is undetectable, stays where you apply it, and provides fast and effective numbing of oral pain
  • ADA Accepted: Accepted by the American Dental Association and has shown efficacy to help temporarily relieve discomfort of mouth sores
  • Convenient: Take the tiny Anbesol gel tube with you for oral pain relief on-the-go up to 4x daily. For adults and children 2 years and older with adult supervision. Use as directed
SaleNo. 14
Benzodent Dental Pain Relieving Cream for Dentures and Braces, Topical Anesthetic, 0.25 Ounce Tube
  • FOR DENTAL PAIN: Benzodent provides temporary relief of pain for oral discomfort caused by dentures, braces or sores, with the maximum amount of benzocaine allowed in an over the counter oral product.
  • LONG LASTING RELIEF: Benzodent is a thick topical cream that provides pain relief with the strength of benzocaine. The unique formula cushions & adheres to gums for pain relief that lasts for hours.
  • GREAT FOR DENTURES OR BRACES: Dentures & braces can rub against your gums, tongue, or the inside of your cheeks and lips causing painful sores. Benzodent numbs the area for temporary pain relief.
  • CONTAINS BENZOCAINE: Benzodent is a highly effective temporarily oral pain relief cream with the maximum strength of Benzocaine. Don't suffer through your meals or lie awake at night with mouth pain.
  • BENZODENT BRINGS PROVEN RELIEF: Benzodent is the dentist-preferred topical anesthetic to temporarily relieve oral pain associated with new or ill-fitting dentures, orthodontics or other mouth sores.
SaleNo. 15
Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- From #1 Oral Pain Relief Brand
  • INSTANT PAIN RELIEF: Orajel Mouth Sore Gel contains 20% Benzocaine to relieve pain from canker sores, mouth sores, cold sores and other mouth irritations
  • SOOTHING RELIEF: Maximum strength gel uses menthol to soothe irritated and sore gums quickly, where you need it most
  • PROTECTION: Our unique, fast acting, formula contains an astringent to help protect sores from irritation, including irritation from dentures or braces, as well as canker sores
  • EASY OPEN: Now with a Ready-Open Tube Tip for easy access to the relief you need. A convenient remedy for use at home or on the go.
  • From the #1 Oral Pain Reliever Brand for Adults
SaleNo. 16
Kank-A Soft Brush Tooth/Mouth Pain Gel, Professional Strength , 0.07 Ounce
  • Softbrush Pain Gel
  • Delivers medication in a pleasant tasting gel
  • Combines maximum pain relief with a potent oral astringent for fast relief from ill-fitting oral appliances, toothaches, or minor gum irritation
  • Unique, pen-like applicator makes it easy to apply directly to affected areas
SaleNo. 18
Benzodent Dental Pain Relieving Cream for Dentures and Braces, Topical Anesthetic, 1 Ounce Tube
5,521 Consomer Reviews
Benzodent Dental Pain Relieving Cream for Dentures and Braces, Topical Anesthetic, 1 Ounce Tube
  • FOR DENTAL PAIN: Benzodent provides temporary relief of pain for oral discomfort caused by dentures, braces or sores, with the maximum amount of benzocaine allowed in an over the counter oral product.
  • LONG LASTING RELIEF: Benzodent is a thick topical cream that provides pain relief with the strength of benzocaine. The unique formula cushions & adheres to gums for pain relief that lasts for hours.
  • GREAT FOR DENTURES OR BRACES: Dentures & braces can rub against your gums, tongue, or the inside of your cheeks & lips causing painful sores. Benzodent numbs the area for temporary pain relief.
  • CONTAINS BENZOCAINE: Benzodent is a highly effective temporarily oral pain relief cream with the maximum strength of Benzocaine. Don't suffer through your meals or lie awake at night with mouth pain.
  • BENZODENT BRINGS PROVEN RELIEF: Benzodent is the dentist-preferred topical anesthetic to temporarily relieve oral pain associated with new or ill-fitting dentures, orthodontics or other mouth sores.
SaleNo. 19
MagniLife Leg & Back Pain Relief, Fast-Acting for Sciatica Pain, Naturally Soothe Burning, Tingling and Stabbing Pains - 125 Tablets
  • NATURAL PAIN RELIEF - Constant pain in your lower body can be distracting and debilitating. Get relief today with this pain reliever developed to specifically target pain symptoms in the lower back, buttocks and legs and sciatica symptoms. Leg & Back Pain Relief are fast dissolving tablets to help ease burning, tingling and stabbing pains in your lower body.
  • ALL-NATURAL INGREDIENTS - Naturally derived blend soothes aching, uncomfortable pain in legs and back with magnesium, sweet and chili peppers, colocynthis and cudweed. Our quick dissolve tablets contain active ingredients to help deliver fast-acting, serious relief when you need it most.
  • SYMPTOMATIC OR PREVENTATIVE - Our quick-dissolve tablets may be used to treat pain immediately or to prevent symptoms and have no known side effects so you can take them 2 to 3 times a day and go back to business as usual.
  • SAFE, PLANT-DERIVED BLEND - A great benefit of our tablets is they can be taken with other OTC or prescription medications. A safe option for someone who is currently taking medication or wants to avoid medicines that can be harsh on the body.
  • TRUSTED BRAND WITH YOU IN MIND - MagniLife has been a trusted business for over 20 years. All of our products are developed and manufactured in our state-of-the art facilities. Made with highly qualified formulators to ensure excellence in quality and consistency, we ensure top quality products and are dedicated to providing products that help to improve quality of life. Start your journey to a healthy lifestyle today!
SaleNo. 20
Genexa Acetaminophen 500mg Extra Strength Pain Reliever & Fever Reducer Caplets | Pain Relief Medications & Treatments of Headache, Backache, Toothache, & Minor Arthritis | 100 Count
  • [Pain Relief & Fever Reducer]: Genexa Extra Strength Acetaminophen offers an effective solution for temporarily reducing fever and relieving minor aches and pains due to headache, toothache, minor pains of arthritis, backache, the common cold, and premenstrual and menstrual cramps for both adults and children aged 12 and older
  • [Fast Acting Acetaminophen Formula]: Genexa Extra Strength pills feature 500mg acetaminophen caplets, that helps to provide relief to minor aches, pains, and fever. Ideal for common colds, toothaches, headaches, backaches, and menstrual cramps.
  • [Easy to Swallow Caplets]: With a smooth coating and a streamlined design, these caplets are exceptionally easy to swallow, ensuring a hassle-free experience for all users.
  • [Ingredients You Want]:Genexa Extra Strength Pain and Fever Relief is made with the same effective acetaminophen as Extra Strength Tylenol Caplets, but without artificial fillers or dyes.
  • [Clean Medicine]: Genexa Infants' Pain & Fever oral suspension is made with the same effective active ingredients you need, and is free from artificial preservatives, artificial dyes, and common allergens, ensuring a clean over-the-counter medicine for your pain and fever reduction.
  • If you are pregnant, please be sure to check with your doctor before taking acetaminophen.

How to choose a good oral pain relief medications

Does the idea of finding a fantastic oral pain relief medications make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in oral pain relief medications. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top oral pain relief medications products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top oral pain relief medications on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top oral pain relief medications brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top oral pain relief medications based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the oral pain relief medications were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good oral pain relief medications, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your oral pain relief medications.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting oral pain relief medications for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our oral pain relief medications. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what oral pain relief medications should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on oral pain relief medications.