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The 8 Best oral pain treatments of 2025

Are you trying to find oral pain treatments among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling oral pain treatments on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 16 hours of research and did 65 oral pain treatments tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best oral pain treatments you can buy today

SaleNo. 1
Orajel 4X for Toothache & Gum Pain: Severe Cream Tube 0.33oz- From Oral Pain Relief Brand
  • INSTANT PAIN RELIEF: Instant pain relief with Orajel’s unique 4X clinical strength formula to help relieve pain of the tooth and gums
  • 4X ACTIVE INGREDIENTS: With 4 active ingredients, Orajel Cream provides fast acting and maximum strength relief when you need it most
  • KILLS HARMFUL BACTERIA: Unique formula is designed to help kill harmful bacteria in the mouth, and can help to prevent infections
  • COOLING RELIEF: To help relieve gum irritation, Orajel 4X cream contains cooling relief
  • EASY OPEN: Now with a Ready-Open Tube Tip for easy access to the relief you need. A convenient remedy for use at home or on the go.
SaleNo. 2
Anbesol Maximum Strength Oral Pain Relief Gel, Instant Pain Relief For Toothache Pain, Canker Sores, Sore Gums, Mouth Sores, Denture Pain, and Aligner Pain, ADA Accepted, 0.33 oz (packaging may vary)
  • INSTANT PAIN RELIEF: Instant oral pain relief for mouth and gum irritation due to toothaches, canker sores, sore gums, denture pain, and minor dental procedures. Use with dentures to relieve discomfort.
  • MAXIMUM STRENGTH: Instant relief that takes you from ouch to ahhh! So, oral pain doesn’t hold you back. Formulated with 20% Benzocaine to offer maximum strength pain relief and instantly soothe mouth pain and dental irritation
  • EASY TO USE: Cut the Tube Tip for easy access to the oral pain relief you need; Adults and children 2 years and over. Not for use in children under 2 years of age.
  • ACTIVE INGREDIENT: Benzocaine 20% Oral anesthetic for pain relief.
No. 3
Anbesol Maximum Strength Oral Anesthetic Liquid - 0.41 fl oz (packaging may vary)
  • Instant Oral Pain Relief: Anbesol Maximum Strength Liquid for mouth pain, including toothache pain, canker sores, sore gums, mouth sores, denture pain, braces, retainer and aligner pain, and minor dental procedures
  • OW to WOW! Instantly: Formulated with the active ingredient Benzocaine, an oral pain reliever, and numbs instantly to temporarily relieve toothaches, gum pain, canker sores and aligner pain.
  • Liquid Formula: Anbesol Liquid Formula goes on clear and is undetectable, stays where you apply it, and provides fast and effective numbing of oral pain
  • ADA Accepted: Accepted by the American Dental Association and has shown efficacy to help temporarily relieve discomfort of mouth sores
  • Convenient: Take the tiny Anbesol gel tube with you for oral pain relief on-the-go up to 4x daily. For adults and children 2 years and older with adult supervision. Use as directed
SaleNo. 4
DenTek Instant Oral Pain Relief Maximum Strength Kit for Toothaches | 50 Count
  • DenTek Instant Pain Relief, Advanced Kit gives instant and precise relief from oral pain and toothaches
  • Ergonomic handle to reach any area of the mouth gives simple, no-fingers no-mess, relief
  • Fresh Mint flavored Benzocaine relieves tooth pain, sore gums and mouth sores
  • Maximum strength pain reliever
  • 50 disposable applicators easily slide into the handle for a sanitary way to relieve tooth pain
  • DenTek Instant Pain Relief, Advanced Kit includes 1 bottle of Benzocaine (20%) 3.5 mL, 50 count disposable applicators, applicator handle and carrying case
SaleNo. 5
Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- From #1 Oral Pain Relief Brand
  • INSTANT PAIN RELIEF: Orajel Mouth Sore Gel contains 20% Benzocaine to relieve pain from canker sores, mouth sores, cold sores and other mouth irritations
  • SOOTHING RELIEF: Maximum strength gel uses menthol to soothe irritated and sore gums quickly, where you need it most
  • PROTECTION: Our unique, fast acting, formula contains an astringent to help protect sores from irritation, including irritation from dentures or braces, as well as canker sores
  • EASY OPEN: Now with a Ready-Open Tube Tip for easy access to the relief you need. A convenient remedy for use at home or on the go.
  • From the #1 Oral Pain Reliever Brand for Adults
SaleNo. 6
Canker-X Mouth Sore Gel, Fast Pain Relief & Healing for Canker Sores, Cheek Bites and Oral Abrasions, Oral Pain Relief Gel, Benzocaine-Free and Alcohol-Free, Adults and Kids 6+ Years, 0.28 fl oz
  • FAST PAIN RELIEF & HEALING GEL: Canker-X canker sore treatment gel provides fast, long-lasting oral pain relief from canker sores, abrasions and more without any burning or numbing sensation. Clinically tested formula with NO Benzocaine and NO alcohol
  • MOUTH SORES TREATMENT: Canker-X soothes canker sores, cheek bites, mouth sores and mouth abrasions often caused by braces and dentures. The alcohol-free and benzocaine-free oral pain relief gel promotes healing and relieves pain
  • SOOTHES, HYDRATES & PROTECTS: The unique and clinically tested Canker-X gel formula contains Polyvinylpyrrolidone (PVP) which forms a micro-thin protective coating over a mouth sore to block irritants like food & drinks, and relieves discomfort for up to 6 hours
  • HOW TO USE: Use the extended nozzle to easily apply the gel on even hard-to-reach mouth sores. You can also apply gel with a clean finger or cotton swab. Wait 2 mins for the protective barrier to form. For best results, avoid eating/drinking for 1 hour
  • SAFE & EFFECTIVE: Clinically tested, Canker-X Gel is an effective canker sore treatment for both children (6+ years) and adults. Key ingredients are Aloe Vera to soothe, Sodium Hyaluronate to hydrate and Polyvinylpyrrolidone (PVP). Use as needed
No. 7
Orajel 3X for Toothache & Gum Pain: Maximum Gel Tube 0.42oz - From #1 Oral Pain Relief Brand - Orajel for Instant Pain Relief
  • INSTANT PAIN RELIEF: Instant pain relief with Orajel’s maximum strength formula to help relieve pain of the tooth and gums with 20% benzocaine
  • KILLS HARMFUL BACTERIA: Unique formula is designed to help kill harmful bacteria in the mouth, and can help to prevent infections
  • COOLING RELIEF: To help relieve gum irritation, Orajel toothache gel contains cooling relief
  • EASY OPEN: Now with a Ready-Open Tube Tip for easy access to the relief you need. A convenient remedy for use at home or on the go
  • From the Oral Pain Reliever Brand for Adults
No. 8
Benzodent Dental Pain Relieving Cream for Dentures and Braces, Topical Anesthetic, 0.25 Ounce Tube
  • FOR DENTAL PAIN: Benzodent provides temporary relief of pain for oral discomfort caused by dentures, braces or sores, with the maximum amount of benzocaine allowed in an over the counter oral product.
  • LONG LASTING RELIEF: Benzodent is a thick topical cream that provides pain relief with the strength of benzocaine. The unique formula cushions & adheres to gums for pain relief that lasts for hours.
  • GREAT FOR DENTURES OR BRACES: Dentures & braces can rub against your gums, tongue, or the inside of your cheeks and lips causing painful sores. Benzodent numbs the area for temporary pain relief.
  • CONTAINS BENZOCAINE: Benzodent is a highly effective temporarily oral pain relief cream with the maximum strength of Benzocaine. Don't suffer through your meals or lie awake at night with mouth pain.
  • BENZODENT BRINGS PROVEN RELIEF: Benzodent is the dentist-preferred topical anesthetic to temporarily relieve oral pain associated with new or ill-fitting dentures, orthodontics or other mouth sores.
No. 9
Dentemp Canker Sore Medicine 2pk Canker Cover - Oral Pain Reliever (12 Count) - Treatment to Relieve Canker Pain, Mouth Sores & Mouth Irritation - Fast Acting Canker Sore Relief Tablets for Adults
  • CANKER SORE PAIN RELIEF: Our Canker Cover contains six mint-flavored canker sore patches. The tablet forms a protective barrier to protect your canker sores while they heal; The soothing menthol will provide instant pain relief and help get you back to normal quickly. Not only do these tablets help provide relief from canker sores, but they also help protect from mouth irritants. Our tablets help jump-start the healing process, speed up recovery, and prevent outbreaks.
  • FAST AND EFFECTIVE: Dentemp canker sore treatment can help you heal as fast as 1 day, providing soothing relief for up to 12 hours; The canker cover even stays on while eating. Containing no sucrose, glucose, lactose, or preservatives, Dentemp canker cover tablets also have less than one calorie. Our formulation promotes immediate pain relief without irritating the mouth. We have carefully selected the ingredients to ensure they are safe for consumption.
  • EASY APPLICATION: To make sure the tablet sticks on, simply place the tablet on the sore and hold for 10 seconds; Within 30 minutes the tablet forms a clear, gel-like bandage that seals and protects the sore for hours before dissolving. Take our dissolving tablets and experience a cooling sensation while doing so. We have added cool mint to create a refreshing and comforting effect. Dentemp Canker Covers are pleasantly flavored and buffered for safe daily use.
  • DENTAL REPAIR & CLEANING: Dentemp canker cover is specially formulated to reduce canker sore pain and help relieve the pain from small oral wounds and irritation from dentures, braces, and oral ulcers. Whether you need to repair a broken or lost filling, cap or crown, or need a cleaning kit for your retainer, denture, braces, or orthodontic appliance, we've got you covered. Safe for adults, say goodbye to canker sores and mouth sores.
  • OUR PROMISE: At Dentemp, we understand that you are placing your trust in us to provide you with the safest, highest quality dental care products available. We take this trust seriously and we have 100% confidence in the quality of our products and continuously strive to deliver the best customer experience. For all of your denture and oral care needs, explore our full line of products including Dentemp Recap-it, Refil-it, Repair-it, Reline-it, Ora-GUARD, Floss Picks, Oral Care Kit and Clean-it.
No. 10
Rite Aid Maximum Strength Liquid Anesthetic Oral Pain Relief - .5 fl oz, Benzocaine 20% | Pain Relief Medications & Treatments | Canker Sore and Tooth Pain Relief for Adults | Mouth Sores Treatment
  • MOUTH SORE TREATMENT: Rite Aid Max Strength Oral Liquid Anesthetic Benzocaine 20% pain relieving liquid temporarily relieves pain associated with toothaches, sore gums, mouth sores, canker sores, dentures/braces, cheek bites, and minor dental procedures.
  • FAST-ACTING PAIN RELIEF: Rite Aid offers instant relief from pain associated with toothaches, gum pain, canker sores, and dentures/braces. Compare Rite Aid to the leading national brand and get the same reliable mouth pain relief you can count on.
  • MAXIMUM STRENGTH: Formulated with 20% Benzocaine, Rite Aid Maximum Strength Liquid Anesthetic Oral Pain Relief offers the maximum amount of pain relief and aims to temporarily relief the mouth and tooth pain that ails you, so you can live pain free.
  • ADULTS AND CHILDREN 2 YEARS AND UP: Apply to affected area using applicator tip. Use up to 4 times daily or as directed by a doctor. Children under 12 years of age should be supervised in the use of this product. Children under 2 years of age do not use.
  • TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the health and wellness of our communities and provide our customers with the best products, services, and advice.
No. 11
Orajel 2X Medicated Toothache & Mouth Sores Liquid, 0.45 fl oz
  • 20% Benzocaine to relieve oral pain
  • Menthol to soothe gums
  • Fast-acting liquid for instant pain relief
  • #1 Oral Pain Reliever Brand for Toothache
  • 2 times as many active ingredients as single medicated oral pain products
No. 13
Kank-A Soft Brush Tooth & Mouth Pain Gel, Professional Strength, 0.07 Ounce, Dual Relief Formula for Toothaches, Gum & Other Mouth Pain, Easy to Use Pen Applicator, Fast-Acting Pain Relief
  • Softbrush Pain Gel
  • Delivers medication in a pleasant tasting gel
  • Combines maximum pain relief with a potent oral astringent for fast relief from ill-fitting oral appliances, toothaches, or minor gum irritation
  • Unique, pen-like applicator makes it easy to apply directly to affected areas
No. 15
Canker-X Rincinol Oral Rinse Mouthwash, Quick Pain Relief from Canker Sores, Mouth Burns & More, Benzocaine Free & Alcohol Free Mouthwash, Adults & Kids 6+ Years, 4.0 Fl. Oz.
536 Consomer Reviews
Canker-X Rincinol Oral Rinse Mouthwash, Quick Pain Relief from Canker Sores, Mouth Burns & More, Benzocaine Free & Alcohol Free Mouthwash, Adults & Kids 6+ Years, 4.0 Fl. Oz.
  • FAST PAIN RELIEF & HEALING MOUTHWASH: Canker-X canker sore treatment mouthwash provides fast, long-lasting pain relief without any burning or numbing sensation. Canker-X mouthwash is a clinically tested benzocaine-free and alcohol-free formula
  • MOUTH SORES TREATMENT: Canker-X soothes canker sores, cheek bites, mouth burns, gum sores, abrasions from braces and dentures, and other types of mouth sores, relieving pain and promoting healing, while blocking irritants like food and drinks
  • SOOTHES, HYDRATES & PROTECTS: With the goodness of Aloe Vera, Sodium Hyaluronate and Polyvinylpyrrolidone (PVP), this oral care mouthwash works by forming a micro-thin protective coating over mouth sores to quickly relieve pain for up to 6 hours
  • HOW TO USE: Measure 10ml of this canker sore mouthwash using the enclosed cap, and swish it around your mouth for 1 minute. Avoid eating or drinking for at least 1 hour. The Canker-X mouthwash has a pleasant taste and is ideal for multiple mouth sores
  • SAFE & EFFECTIVE: Clinically tested, Canker-X Rincinol Oral Mouthwash is an effective canker sore treatment for both children (6+ years) and adults even if swallowed. Use as needed
No. 16
Orajel Oral Pain Reliever, for All Mouth Sores, Maximum Strength, Gel 0.42 Oz, 11.9 G (Pack of 2)
  • 20% Benzocaine to Relieve Oral Pain
  • Menthol to Soothe Gums
  • Astringent to Help Protect Sores from Irritation
  • Now with a Ready-Open Tube Tip for easy access
  • #1 Oral Pain Reliever Brand for Adults
No. 17
IODENT ORAL ANALGESIC GEL 0.42 OZ
  • Iodent Compare to the active ingredient of ORAJEL
  • ORAJEL
SaleNo. 18
Canker-X Mouth Sore Spray, Oral Pain Relief from Canker Sores, Burns & More, No Burning & Numbing, Benzocaine-Free & Alcohol-Free Mouth Ulcer Treatment, Targeted Spray Nozzle, 0.51 Fl. Oz.
  • FAST PAIN RELIEF & HEALING MOUTH SORE SPRAY: Canker-X canker sore treatment spray provides fast, long-lasting pain relief from canker sores, abrasions and more, without any burning or numbing sensation. Clinically tested benzocaine-free & alcohol-free formula
  • MOUTH SORES TREATMENT: Canker-X soothes canker sores, cheek bites, mouth burns, abrasions from braces and dentures, and other types of mouth sores, relieving pain and promoting healing, while blocking irritants like food and drinks
  • SOOTHES, HYDRATES & PROTECTS: With the goodness of Aloe Vera, Sodium Hyaluronate, and Polyvinylpyrrolidone (PVP), this oral pain relief spray works by forming a micro-thin protective coating over mouth sores to quickly relieve pain and discomfort for up to 6 hours
  • HOW TO USE: Use the targeted application spray nozzle for precise application on your mouth sores - even those at the back of your mouth and tongue. After attaching the nozzle to the bottle, spray directly 3 times or as needed to cover the affected area
  • SAFE & EFFECTIVE: Clinically tested, Canker-X Mouth Sore Spray is an effective canker sore treatment for both children (6+ years) and adults even if swallowed. Use as needed
SaleNo. 19
Orajel 4X for Toothache & Gum Pain Severe Gel Tube, No Color, 0.25 Ounce
  • Clinical Strength Pain Relief
  • Proven to Kill Harmful Bacteria
  • Helps Prevent Infection
  • Cooling Relief for Gum Irritation
  • Now with a Ready-Open Tube Tip for easy access #1 Oral Pain Reliever Brand for Toothache
No. 20
Benzodent Dental Pain Relieving Cream Topical Anesthetic, No Artificial Color & Flavors
5,521 Consomer Reviews
Benzodent Dental Pain Relieving Cream Topical Anesthetic, No Artificial Color & Flavors
  • FOR DENTAL PAIN: Benzodent provides temporary relief of pain for oral discomfort caused by dentures, braces or sores, with the maximum amount of benzocaine allowed in an over the counter oral product.
  • LONG LASTING RELIEF: Benzodent is a thick topical cream that provides pain relief with the strength of benzocaine. The unique formula cushions & adheres to gums for pain relief that lasts for hours.
  • GREAT FOR DENTURES OR BRACES: Dentures & braces can rub against your gums, tongue, or the inside of your cheeks & lips causing painful sores. Benzodent numbs the area for temporary pain relief.
  • CONTAINS BENZOCAINE: Benzodent is a highly effective temporarily oral pain relief cream with the maximum strength of Benzocaine. Don't suffer through your meals or lie awake at night with mouth pain.
  • BENZODENT BRINGS PROVEN RELIEF: Benzodent is the dentist-preferred topical anesthetic to temporarily relieve oral pain associated with new or ill-fitting dentures, orthodontics or other mouth sores.

How to choose a good oral pain treatments

Does the idea of finding a fantastic oral pain treatments make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in oral pain treatments. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top oral pain treatments products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top oral pain treatments on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top oral pain treatments brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top oral pain treatments based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the oral pain treatments were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good oral pain treatments, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your oral pain treatments.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting oral pain treatments for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our oral pain treatments. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what oral pain treatments should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on oral pain treatments.