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The 8 Best proteolytic enzymes for inflammation of 2025

Are you trying to find proteolytic enzymes for inflammation among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling proteolytic enzymes for inflammation on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 21 hours of research and did 22 proteolytic enzymes for inflammation tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best proteolytic enzymes for inflammation you can buy today

No. 2
Carlyle Proteolytic Enzymes | 300 Capsules | Systemic Broad Spectrum Supplement | Vegetarian, Non-GMO & Gluten Free Formula
  • PROTEOLYTIC ENZYMES: Can be found naturally in certain foods like papaya and pineapple
  • BROAD SPECTRUM: Features an Advanced Enzyme Complex with Premium Turmeric Curcumin for added support
  • ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living
  • CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
  • NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Artificial Flavor, Sweetener, Preservatives & Non-GMO
No. 3
HEAL-N-SOOTHE Proteolytic Enzymes - Natural Joint Support Supplement - Unique Blend of Bromelain, Papain, Boswellia, and Turmeric - 90 Count
  • Proteolytic Systemic Enzyme Joint Support System - Heal-n-Soothe contains a blend of Proteolytic Enzymes, Turmeric Extract, Bromelain, Boswellia Extract, Papain, Rutin, Mojave Yucca Root, Devil's Claw, Citrus Bioflavonoids, Alpha Lipoic Acid and Ginger supplement
  • Scientifically formulated - Heal-n-Soothe is All-Natural & Vegetarian. No Gluten, No GMOs, No Added Sugars, No Dairy, and No Fillers or Binders.
  • Supports Healthy Immune System - High potency preteolytic enzyme blend that is scientifcally shown to support a healthy immune system
No. 4
Wonder Laboratories Proteolytic Enzymes | Bromelain Papain Pancreatin Trypsin 550 mg Total with Standardized Amylase, Lipase, and Protease, 300 Tablets
  • Nutritionally Supports Your Body's Natural Response to Inflammation, Immune Function, and Supports Digestive and Intestinal Health*
  • Contains Bromelain, Lipase, Trypsin, Papain, Pancreatin, Chymotrypsin, Protease, and Amylase
  • Bromelain and Proteolytic Enzymes to help support the breakdown of proteins in digestion, immune function, and other vital processes.*
  • Amylase Lipase Bromelain Digestive Enzymes Organic Sources to provide you with a well formulated digestive enzyme
  • MADE IN USA - Manufactured and packaged in the USA by a family owned and operated company since 1962.
No. 5
Amvilab - Proteolytic Enzymes - Trypsin & Chymotrypsin - Reduces Edema & Inflammation From Tissue Injury - Supports Digestive, Tissue & Immune Health - Recovery Boost - Dietary Supplement -60 Capsules
  • PROTEOLYTIC ENZYMES - Amvilab’s Systemic Proteolytic Enzymes contain a combination of Trypsin & Chymotrypsin to improve joint and muscle health by helping important metabolic pathways. This supplement helps support protein metabolism pathway, immune system health, a healthy circulatory function, and more.
  • BOOST IMMUNE SYSTEM HEALTH - Backed by scientific evidence, our Systemic Proteolytic Enzymes boost the immune system by helping clear the debris and bad proteins that cause inflammation in the body. This supplement helps keep you robust and resilient.
  • REDUCES INFLAMMATION & PAIN - Ingredients like Trypsin and Chymotrypsin work on micro-wounds to clear debris, acting as a pro-healing supplement. Countering inflammation and reducing edema in accidental injuries, this supplement is perfect for after surgical and orthopedic injuries, and burns.
  • IMPROVES CIRCULATION & DIGESTION - Systemic Proteolytic Enzymes for inflammation help to initiate tissue repair, remove dead cells, and reduce blockages in vessels, allowing healthy tissues to grow. Acting as a natural detox and digestive ally, this supplement breaks down harmful substances and food, supporting a cleaner, healthier gut and body.
  • QUALITY ASSURED - This premium blend of Proteolytic Enzymes supplements are GMP certified, Gluten Free, Non-GMO and are made in the USA. Take 2 capsules 3 times daily for maximum benefits. Don’t wait any longer to take control of your health and well-being, start your journey to elevate your wellness.
No. 6
Designs for Health Inflammatone - Turmeric Supplements with Proteolytic Enzymes, Boswellia, Quercetin & Resveratrol (60 Capsules)
  • A comprehensive blend of proteolytic enzymes, polyphenols, and botanical extracts.
  • Formulated to contain botanical extracts standardized to meet targeted amounts of bioactive ingredients.
  • InflammEnz proprietary proteolytic enzyme blend that is highly resistant to stomach acid and can be absorbed intact from the small intestine into the bloodstream.*
  • Over 50,000 Doctors Agree - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients.
  • Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**
  • English (Publication Language)
SaleNo. 7
Piping Rock Proteolytic Enzymes Supplement | 120 Capsules | Broad Spectrum Complex | Vegetarian, Non-GMO, Gluten Free
  • Superior quality at the best value
  • Designed to support your lifestyle goals
  • Devoted to Purity, Potency and Safety!
  • Non-GMO and Gluten Free
  • Laboratory Tested, using Trusted Ingredients
No. 8
HerbaMe Proteolytic Enzymes Supplement with Serrapeptase - Devils Claw, 90 Capsules, Promotes Joints Relief, Muscle and Tissue Health with Lasting Mobility, Athletes Post Workout Recovery Support
  • Healthy Immune Response and Circulation – A premier blend of proteolytic enzymes and a natural herbal complex with white willow bark, ginger, and devil's claw root our formula helps with aching joints and muscle support while promoting blood circulation and digestive health.
  • Supports Active Mobility and Flexibility – our root extracts, enzymes, and nutrients may help muscle and tissue recovery support. Proteolytic enzyme blend for muscle tissue recovery time. Recommended to take 2 capsules daily with food after surgery and continue for 4-6 months to optimize healing and recovery.
  • Fortify Year-Round Immune Function – Supporting digestion, improving blood flow, and minimizing overexertion can all help you to promote immune system health which is important for overall body health and wellness.
  • Protect Joints, Tendons and Muscles – HerbaMe PainCare nutritional supplements play a positive role for people with active lifestyles or athletes, especially those who struggle with pain, joints, sore muscles after working out, and minor body aches due to overactivity.
  • Advanced Purity and 3rd Party Tested – Formulated in the USA in a GMP-certified facility our non-GMO Proteolytic enzymes with herbal blend supplement contains no artificial flavors or harsh additives for clean, efficient support. It’s also backed by a 100% satisfaction guarantee.
No. 9
WellnessOne ProOneZyme Digestive Enzymes Supplements - Systemic Proteolytic Enzymes for Digestion, Gut Health, Gas Relief & Bloating - Contains Bromelain, Nattokinase, Protease & More - 90 Capsules
  • 𝗖𝗼𝗺𝗽𝗹𝗲𝘁𝗲 𝗗𝗶𝗴𝗲𝘀𝘁𝗶𝗼𝗻 𝗦𝘂𝗽𝗽𝗼𝗿𝘁 - Break down complex foods with ease. Our proprietary systemic enzymes blend includes protease, bromelain, nattokinase, seaprose-s, papain, and more to help digest proteins, fats, dairy, gluten, and carbs.
  • 𝗚𝗮𝘀 𝗮𝗻𝗱 𝗕𝗹𝗼𝗮𝘁𝗶𝗻𝗴 𝗥𝗲𝗹𝗶𝗲𝗳 - Say goodbye to discomfort! Our enzymes help break down food completely, minimizing gas and bloating for a more comfortable digestive experience. Take 3 capsules daily at the beginning of a meal.
  • 𝗘𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲 𝗔𝗹𝗹 𝘁𝗵𝗲 𝗪𝗮𝘆 𝗧𝗵𝗿𝗼𝘂𝗴𝗵 - Our proprietary systemic enzymes work throughout your entire digestive system, regardless of varying pH levels. This means faster relief from gas, bloating, and indigestion for maximum digestive comfort.
  • 𝗨𝗻𝗹𝗼𝗰𝗸 𝗘𝘀𝘀𝗲𝗻𝘁𝗶𝗮𝗹 𝗡𝘂𝘁𝗿𝗶𝗲𝗻𝘁𝘀 - Get the most out of your meals! Our digestive enzymes for women and men help break down proteins, fiber, and carbohydrates, promoting better nutrient absorption and supporting overall digestive health.
  • 𝗦𝘁𝗿𝗲𝗻𝗴𝘁𝗵𝗲𝗻𝘀 𝗗𝗲𝗳𝗲𝗻𝘀𝗲𝘀 & 𝗦𝘂𝗽𝗽𝗼𝗿𝘁𝘀 𝗢𝘃𝗲𝗿𝗮𝗹𝗹 𝗛𝗲𝗮𝗹𝘁𝗵 - A healthy gut is key to overall well-being! Our enzymes promote a balanced gut microbiome, potentially enhancing your body's natural defenses.
  • 𝗠𝗮𝗱𝗲 𝘄𝗶𝘁𝗵 𝗬𝗼𝘂 𝗶𝗻 𝗠𝗶𝗻𝗱 - ProOneZyme is formulated by vitamin experts using high-quality, Non-GMO ingredients. Manufactured in a GMP-certified facility for your peace of mind. We prioritize customer satisfaction, so feel free to reach out if you have any questions!
SaleNo. 10
Natural Factors - Zymactive Proteolytic Enzyme Double Strength, Supports a Healthy Inflammatory Response to Help Muscle and Joint Function, Gluten Free, Non-GMO, 30 Enteric Coated Tablets
  • POTENT PROTEOLYTIC ENZYMES: Enteric coated double strength tablets to support joint and muscle inflammation.
  • NATURAL ENZYME SUPPORT: Zymactive is an advanced formula that provides systemic enzyme support for the body's natural healthy inflammatory response and immune system
  • LOCAL, ORGANIC, AND NON-GMO: Because Natural Factors Farms are certified organic, we don't pollute the earth with pesticides and chemical fertilizers. We grow true species non-hybridized, non-GMO seeds, including many open-pollinated varieties. Growing locally also helps reduce the carbon emissions from overseas transportation, and keep jobs in the community.
  • JUST THE RIGHT SIZE: We believe we need to be big enough to do it right. We are one of the only nutritional companies to have our own organic farms, our own extraction, encapsulation, and production facilities, our own labs and research facilities. We are also one of the few branded manufacturers of nutraceuticals in North America to have our own soft gel encapsulation facility.
  • WHERE GREAT HEALTH BEGINS: Today, Natural Factors is one of the largest manufacturers of nutritional products in North America. But our origins reach back to the 1950s, and right from day one, we've always been fully committed to making products right. We are not a public company with shareholders to impress. Instead, we care about impressing you.

How to choose a good proteolytic enzymes for inflammation

Does the idea of finding a fantastic proteolytic enzymes for inflammation make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in proteolytic enzymes for inflammation. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top proteolytic enzymes for inflammation products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top proteolytic enzymes for inflammation on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top proteolytic enzymes for inflammation brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top proteolytic enzymes for inflammation based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the proteolytic enzymes for inflammation were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good proteolytic enzymes for inflammation, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your proteolytic enzymes for inflammation.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting proteolytic enzymes for inflammation for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our proteolytic enzymes for inflammation. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what proteolytic enzymes for inflammation should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on proteolytic enzymes for inflammation.