Are you trying to find systemic enzymes among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!
We investigated and evaluated a number of the top-selling systemic enzymes on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 15 hours of research and did 21 systemic enzymes tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!
An overview of our top picks
Table of contents
The best systemic enzymes you can buy today
- Essential Enzyme Blend: Systemic Enzyme Complex protease enzyme supplement features pancreatin, protease, serrazimes, bromelain, and papain for muscle, joint, and immune health*
- Enzyme Support: Formulated with papaya fruit and other enzymes, this blend offers impressive overall health support, supporting muscle comfort and recovery*
- Joint Health: Formula contains 250 mg of Indian frankincense (Boswellia serrata), a potent boswellia supplement for robust joint support and cartilage health*
- Suggested Use: As a dietary supplement, take 3 digestive enzyme capsules, 1-2 times daily, between meals
- Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs
- PROTEOLYTIC ENZYMES: Can be found naturally in certain foods like papaya and pineapple
- BROAD SPECTRUM: Features an Advanced Enzyme Complex with Premium Turmeric Curcumin for added support
- ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living
- CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
- NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Artificial Flavor, Sweetener, Preservatives & Non-GMO
- THE CLINICALLY STUDIED FORMULA: First introduced in Germany over 40 years ago, the Wobenzym N formula includes pancreatin protease, papain, bromelain, trypsin, chymotrypsin, rutoside trihydrate to help maintain healthy joints, mobility and flexibility
- A TRADITION OF SUCCESS: Wobenzym N is a global leader in joint health and is the only systemic enzyme formula backed by decades of clinical research & customer satisfaction; Systemic enzymes work throughout the entire body to support overall joint health
- HELPS IMPROVE JOINT COMFORT AND RANGE OF MOTION: Get going with Wobenzym N, the authentic systemic enzyme formula trusted by millions worldwide to provide clinically demonstrated support for joint & tendon health; For speedy recovery following exertion
- GLUTEN FREE AND DAIRY FREE SYSTEMIC ENZYME FORMULA: A synergistic combination of plant-based enzymes, pancreatic enzymes & antioxidants—with Carica papaya and Sophora japonica; Temporary relief from aches, pains & muscle soreness due to everyday activity
- FUEL YOUR HEALTH: Enzymes are essential biological catalysts involved in almost every single process in our bodies; Our powerful yet delicate enzymes are protected by a vegetable-based enteric coating for optimal absorption and utilization
- Enteric Coated Advanced Delivery Method: Vitalzym high potency gel caps are unlike any tablet or powder based enzyme product available on the market today. Our formula contains no gluten, yeast or dairy and is designed to ensure maximum absorption into the bloodstream where it is then dispersed via your circulatory system throughout your body
- Ingredients: Vitalzym Extra Strength premium softgels are the original, all-natural, vegetarian multi enzyme complex. Vitalzym was designed using a scientific research process to identify nature’s miracle ingredients that include Serrapeptase, Bromelain, Papain, Rutin, Amylase, Protease, Lipase and Amla Extract
- Protect Your Health: Living well in modern times can be stressful and a source of pain at times. Vitalzym contains the most effective, purified vegan-based enzyme blend to promote healing, human bodily functions and leave you feeling clear and fresh
- Small, Easy To Swallow Gel Caps: Our advanced encapsulations deliver reliable results that offer pure, potent enzymes with reliable consistency and unrivaled absorption rates. Due to the highly effective delivery rate most people need a smaller dosage, and less doses per day
- Made In Japan: Created by a team of international scientists, Vitalzym works best when combined with exercise, proper fluid intake, and a healthy diet. It is important to be mindful of all aspects of your health. When used properly, Vitalzym can assist with cardio, lung, and immune response as well as provide joint, inflammation support and much more
- FIBRENZA SUPPLEMENT: An advanced blend of 13 powerful systemic enzymes! HCP Formulas' Fibrenza is a natural systemic enzyme complex. Formulated with fibrinolytic & proteolytic enzymes, Fibrenza supports the body's ability to dissolve fibrin and cleanse the body of impurities for maximum body-wide benefits in a reliable, time-released capsule.
- CARDIOVASCULAR SUPPORT: Aging lowers your body's ability to produce sufficient levels of enzymes, often leading to build-up of fibrin. Fibrenza harnesses potent systemic enzymes that break down proteins, toxins, and other cellular debris, such as Serrapeptase and Nattokinase—helping to maintain a healthy cardiovascular system.
- ANTIOXIDANT: Enzymes possess profound antioxidant properties. These properties are the foundation of anti-aging and detoxification protocols, Superoxide Dismutase helps break down potentially harmful oxygen molecules in cells that help to maintain overall well-being.
- SUPERIOR DELIVERY: Fibrenza utilizes a technologically advanced capsule without phthalates. Unlike enteric coatings, AcidDefenz capsules use a non-GMO vegetable cellulose barrier to provide for a time-release for more consistent enzyme absorption.
- PREMIUM INGREDIENTS: HCP Formulas specializes in ultra-premium nutraceutical supplements to better support your health. We source only the highest-grade Non-GMO ingredients that are vegetarian and free of gluten, dairy, wheat, yeast, and shellfish. Fibrenza contains NO Phthalates, Talc, or artificial colors or flavors and is proudly manufactured in the USA in GMP registered facilities.
- ADVANCED SYSTEMIC ENZYME FORMULA: a potent blend of enzymes, including acid-resistant serrapeptase & proteases, and herbs that synergistically support the body’s natural response to inflammation and joint function; used for more than a decade by thousands of people as a daily dietary supplement.*
- RANGE OF USE: Supports the body’s natural response to inflammation including fatigued muscles and joint function, healthy blood circulation, and healthy fibrin metabolism.*
- ACHIEVE OPTIMAL HEALTH: Elimination of potential waste substances from the body is a crucial step in metabolic processes for optimal health. Excellacor improves the body’s ability to rid of these wastes and restore normal balance.*
- QUALITY ASSURED: All products by AST Enzymes are manufactured in the USA, free of animal derivatives, dairy, yeast, fish or shellfish, peanuts, and tree nuts.
- 𝗖𝗼𝗺𝗽𝗹𝗲𝘁𝗲 𝗗𝗶𝗴𝗲𝘀𝘁𝗶𝗼𝗻 𝗦𝘂𝗽𝗽𝗼𝗿𝘁 - Break down complex foods with ease. Our proprietary systemic enzymes blend includes protease, bromelain, nattokinase, seaprose-s, papain, and more to help digest proteins, fats, dairy, gluten, and carbs.
- 𝗚𝗮𝘀 𝗮𝗻𝗱 𝗕𝗹𝗼𝗮𝘁𝗶𝗻𝗴 𝗥𝗲𝗹𝗶𝗲𝗳 - Say goodbye to discomfort! Our enzymes help break down food completely, minimizing gas and bloating for a more comfortable digestive experience. Take 3 capsules daily at the beginning of a meal.
- 𝗘𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲 𝗔𝗹𝗹 𝘁𝗵𝗲 𝗪𝗮𝘆 𝗧𝗵𝗿𝗼𝘂𝗴𝗵 - Our proprietary systemic enzymes work throughout your entire digestive system, regardless of varying pH levels. This means faster relief from gas, bloating, and indigestion for maximum digestive comfort.
- 𝗨𝗻𝗹𝗼𝗰𝗸 𝗘𝘀𝘀𝗲𝗻𝘁𝗶𝗮𝗹 𝗡𝘂𝘁𝗿𝗶𝗲𝗻𝘁𝘀 - Get the most out of your meals! Our digestive enzymes for women and men help break down proteins, fiber, and carbohydrates, promoting better nutrient absorption and supporting overall digestive health.
- 𝗦𝘁𝗿𝗲𝗻𝗴𝘁𝗵𝗲𝗻𝘀 𝗗𝗲𝗳𝗲𝗻𝘀𝗲𝘀 & 𝗦𝘂𝗽𝗽𝗼𝗿𝘁𝘀 𝗢𝘃𝗲𝗿𝗮𝗹𝗹 𝗛𝗲𝗮𝗹𝘁𝗵 - A healthy gut is key to overall well-being! Our enzymes promote a balanced gut microbiome, potentially enhancing your body's natural defenses.
- 𝗠𝗮𝗱𝗲 𝘄𝗶𝘁𝗵 𝗬𝗼𝘂 𝗶𝗻 𝗠𝗶𝗻𝗱 - ProOneZyme is formulated by vitamin experts using high-quality, Non-GMO ingredients. Manufactured in a GMP-certified facility for your peace of mind. We prioritize customer satisfaction, so feel free to reach out if you have any questions!
- American Made, Essential for Health, Plant Based: Not All Complete Digestive System Enzyme Products Are Made The Same - Pay For True Quality & You Will Not Be Disappointed. World Nutrition is a pioneer of complementary systemic enzymes. In 2001 we introduced the original Vitalzym pill as a hybrid formula that offers both systemic & digestive benefits to provide total body support. It quickly became the best-selling systemic enzyme in the world and sold over $10M in the first 3 years alone
- The Best Vegetarian Digestion Supplement & Remedy: Our Premium Strength Super Gut Defense Formula contains everything you need for full-body support: Protease, Serrapeptase, Papain, Bromelain, Amylase, Lipase, Rutin, & Amla. Each powerful ingredient is derived from natural, vegetarian sources. Most competitors use enzymes harvested from pigs & cows after slaughter. These enzymes are low-quality & strength, requiring a much higher dose as they’re less effective against targeted mediators
- Advanced, Broad Spectrum Caps Promote Wellness: Our complex extract provides the optimal potency level of proteolytic enzymes that may assist with IBS, gas, inflammation, regulating your immune system, removing excess plaque & fibrin (fibrous tissue), & support the return of blood volume & flow. Vitälzym capsules are formulated to support health in the following systems: cognitive/mental, upper respiratory, cardiovascular, gastrointestinal, reproductive, joints, connective tissue, & skin
- Fast Response, Organic, Calms Indigestion & Assists With IBS, Gas, Bloating: Regain bowel comfort with our perfect synergistic blend of systemic and digestive enzymes. It starts in the stomach & helps the body to break down food and absorb nutrients. After helping increase digestive abilities, the systemic enzymes take action in the bloodstream, moving throughout your entire body. This unique combination can help to improve your bodily processes and regain your quality of life
- Formulated for Active Vitality Enhancement Plus Recovery: High-quality pure powder filled capsules that break down in your stomach provide digestive support with every dose. Some serrapeptase survives the acidic environment of the stomach and a dosage is released in the small intestine, allowing it to be absorbed into your bloodstream and distributed throughout your whole body. Our customers have reported increased energy, stamina, and recovery from intense exercise
- Nature’s Way Mega-Zyme is a blend of systemic and pancreatic enzymes for digestive support.*
- When taken between meals, formulated to help relieve occasional muscle soreness and discomfort due to overexertion and exercise.* Supports digestion when taken with food.*
- To support digestion, adults take 2 tablets up to three times a day, before each meal.* To relieve occasional muscle soreness & discomfort due to overexertion and exercise, take 2 tablets three times a day between meals.* Not formulated for children
- No artificial colors. Contains milk and sulfites
- At Nature’s Way, we believe nature is the ultimate problem solver. For over 50 years, we have looked to the natural world for inspiration. Our quality vitamins and supplements are formulated to help you find your way to wellness
- Systemic enzyme providing pancreatic enzymes.*
- Bio-Zyme is formulated with systemic enzymes for digestive support and relief of occasional muscle soreness due to overexertion.*
- With undiluted pancreatic enzymes for digestive support.*
- No artificial colors. Contains milk and sulfites.
- Integrative Therapeutics supplements are trusted by physicians and backed by science. Every product is held to our high standards and rigorously tested to empower you on your wellness journey. Because confidence is healthy.
- ACID-RESISTANT: Serrapeptase in Serra-RX has a completely phthalate-free polymer applied to maximize efficacy.*
- SUPPORTS HEALTHY TISSUE REPAIR: Potent proteolytic activity supports the body’s ability to break down proteins, lessen the effects of inflammation in the body, and promote scar tissue health.*
- SUPPORTS MUSCLE & JOINT HEALTH: An all-natural systemic enzyme can provide muscle and joint support through fibrin metabolism.*
- PROMOTES HEALTHY RESPIRATORY & SINUS FUNCTION: An all-natural systemic enzyme like Serrapeptase supports immune cell response, and supports relief from sinus and respiratory build-up of mucus.*
- QUALITY & PURITY YOU CAN TRUST: Manufactured in the USA. Free of wheat, egg, milk, soy, tree nuts, peanuts, fish, shellfish, and sesame.
- Advanced systemic enzyme formula: Serracor-NK is a powerful blend of Acid-Resistant Serrapeptase and Nattokinase, systemic enzymes studied for their fibrinolytic properties, with herbs, CoEnzyme Q10 and magnesium.*
- Achieve: The combination of Serrapeptase and Nattokinase used in addition to a complete array of proteolytic enzymes, makes Serracor-NK a unique blend designed to support well-being and circulation*
- Quality Assured: All products by AST Enzymes are manufactured in the USA, free of animal derivatives, dairy, yeast, fish or shellfish, peanuts, and tree nuts.
- Full Spectrum Enzymes are specially formulated to support enzyme production and promote good gut health along with soothing occasional bloating, gas and upset stomach*
- These capsules are designed for fast absorption to assist in breaking down food quickly, transforming it into molecules used for energy and cell repair*
- With 22 diverse digestive enzymes, this blend is designed with realistic diets in mind, helping break down a variety of food groups for efficient digestion
- Following Dr. Mercola’s belief in providing the best quality products, this formula is GMO free and only contains vegan digestive enzymes
- Developed with you in mind, Dr. Mercola’s physician formulated products are only made with ingredients that meet our premium quality standards. Established in 1997, we have been a trusted source in natural health for over two decades
- VeganZyme is the most advanced, full-spectrum, systemic and digestive enzyme supplement in the world
- Contains the broadest spectrum of vegetarian-based enzymes available anywhere
- Provides systemic enzyme support to break down excess mucus and toxins throughout your body
- Helps your body digest fats, sugars, proteins, carbohydrates, gluten, fruits and vegetables, cereals, legumes, bran, nuts and seeds, soy, dairy and other foods
- ACID-RESISTANT: Serrapeptase in Serra-RX has a completely phthalate-free polymer applied to maximize efficacy.*
- SUPPORTS HEALTHY TISSUE REPAIR: Potent proteolytic activity supports the body’s ability to break down proteins, lessen the effects of inflammation in the body, and promote scar tissue health.*
- SUPPORTS MUSCLE & JOINT HEALTH: An all-natural systemic enzyme can provide muscle and joint support through fibrin metabolism.*
- PROMOTES HEALTHY RESPIRATORY & SINUS FUNCTION: An all-natural systemic enzyme like Serrapeptase supports immune cell response, and supports relief from sinus and respiratory build-up of mucus.*
- QUALITY & PURITY YOU CAN TRUST: Manufactured in the USA. Free of wheat, egg, milk, soy, tree nuts, peanuts, fish, shellfish, and sesame.
- SYSTEMIC ENZYMES: Also known as proteolytic/metabolic enzymes, are carefully formulated to support optimal bodily functions. They play a vital role in breaking down toxins, fibrin, allergens, and other waste products from the body, aiding in maintaining a healthy immune system. Additionally, they help keep joints and cells free of waste and toxins while supporting the body's natural ability to neutralize toxins with the help of antioxidants.
- PREMIUM ENZYME BLEND: Advance formulation of 11 systemic enzymes, including Protease I, Protease II, Protease III, Bromelain, Papain, Peptidase, Peptidase S, Nattokinase, Serrapeptase, Saprose S, and Catalase. These premium enzymes work together to break down tough protein fibers, fibrin, and potentially support the body in clearing excess mucus, aiding in promoting healthy cellular recovery.
- BENEFITS: Unlock a range of health benefits with our advanced systemic enzyme formula, including: support healthy blood circulation and the breakdown of excess mucus, helping keep joints comfortable and mobile, encouraging the delivery of oxygen and nutrient to the cells, supporting in the removal of metabolic waste from the cells, helping clear sinuses and nasal airways from mucus buildup, supporting healthy healing response and boosting the recovery process.
- ADDITIONAL INGREDIENTS: To further enhance potency of systemic enzyme formula, we've added a proprietary blend of 72 minerals to aid in the removal of toxins and waste from the body, potentially protecting it from further injury.
- PLANT-BASED, NON-GMO, AND SAFE FOR ALL: Our premium systemic enzymes are Non-GMO and 100% plant-based, meeting vegan dietary requirements. They are manufactured in a GMP, NSF, NSF Sport, Organic, Kosher certified, and FDA-inspected facility, ensuring the highest quality standards. Made in the USA, our premium systemic enzymes are free from fillers, artificial ingredients, wheat, preservatives, dairy, soy, and gluten, making them ideal for both men and women.
- Powerful Biofilm Defense: SerraDefend’s proteolytic enzymes, Serrapeptase and Nattokinase, act as biofilm busters to support healing, repair, and a balanced immune response while helping to inhibit biofilm formation in the body.
- Digestive Enzyme Blend: SerraDefend also contains a range of digestive enzymes including Protease, Cellulase, Hemicellulase, Chitosanase, and Beta-Glucanase. A multi enzyme formula to support balanced gut flora and healthy digestion in men and women.
- Enteric Coated Serrapeptase: Some enzymes, like Serrapeptase, can be destroyed by your stomach acid before they reach your gut. That's why we only use enteric coated serrapeptase that will safely reach your intestines, for maximum effectiveness.
- Not For Sensitive Guts: Serrapeptase can cause mild stomach upset or nausea in a small group of people with sensitive digestive systems. If you try SerraDefend and find that you are sensitive to serrapeptase, please get in touch and we’ll be happy to help.
- Made With Care: SerraDefend is third party tested and made in a state-of-the-art, GMP-compliant, NSF-certified facility. Our formula is free of nuts, gluten, wheat, soy, and dairy. It’s 100% non-GMO and vegan.
- ADVANCED SYSTEMIC ENZYME FORMULA: a potent blend of enzymes, including acid-resistant serrapeptase & proteases, and herbs that synergistically support the body’s natural response to inflammation and joint function; used for more than a decade by thousands of people as a daily dietary supplement.*
- RANGE OF USE: Supports the body’s natural response to inflammation including fatigued muscles and joint function, healthy blood circulation, and healthy fibrin metabolism.*
- ACHIEVE OPTIMAL HEALTH: Elimination of potential waste substances from the body is a crucial step in metabolic processes for optimal health. Excellacor improves the body’s ability to rid of these wastes and restore normal balance.*
- QUALITY ASSURED: All products by AST Enzymes are manufactured in the USA, free of animal derivatives, dairy, yeast, fish or shellfish, peanuts, and tree nuts.
How to choose a good systemic enzymes
Does the idea of finding a fantastic systemic enzymes make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!
Your presence here indicates that you are interested in systemic enzymes. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top systemic enzymes products available right now. You might be wondering how we came up with the list. How was this buying guide developed?
First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top systemic enzymes on the market right now!
The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:
Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top systemic enzymes brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.
Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top systemic enzymes based on those.
Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.
Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.
Customer ratings: Would it be accurate to suggest that the systemic enzymes were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.
Customer Reviews: Like ratings, provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.
Seller Rank: This is very intriguing! Not only do you need a good systemic enzymes, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.
Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your systemic enzymes.
Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting systemic enzymes for months and years to come.
Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.
Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.
These are the standards by which we selected our systemic enzymes. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.
Why should you believe us?
There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what systemic enzymes should you purchase in 2022?
This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on systemic enzymes.
