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The 8 Best vitamin b6 pyridoxal phosphate of 2025

Are you trying to find vitamin b6 pyridoxal phosphate among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling vitamin b6 pyridoxal phosphate on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 29 hours of research and did 30 vitamin b6 pyridoxal phosphate tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best vitamin b6 pyridoxal phosphate you can buy today

No. 1
Life Extension Pyridoxal 5'-Phosphate Caps—Vitamin B6, 100 mg, Bioactive B6 for cardiovascular, kidney & nerve health—Gluten-Free, Non-GMO, Vegetarian—60 Vegetarian Capsules
  • Big B6 benefits—Vitamin B6 plays a key role in over 100 enzymatic reactions in the body. It also helps inhibit sugar-related glycation reactions—which has a positive impact on many aspects of your health, including your heart, nerves, eyes and kidneys.
  • Better B6 bioaction—Pyridoxal 5'-Phosphate is the metabolically active form of vitamin B6, which means it works better in your body and is more bioavailable for the important tasks it needs to do, like supporting your nervous and immune systems.
  • Anti-aging defense—Vitamin B6 is a defender against the glycation compounds (AGEs) which contribute to the signs of normal aging (like wrinkles). It can actually help inhibit those compounds from forming, which can help you to look and feel younger.
  • Ingredients matter—We use only the finest raw ingredients with the purity and potency you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USA—and a Certificate of Analysis is available for every one.
  • Live your healthiest life—We believe the answers to a healthier life are within reach, and that scientific research is the key to getting us there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies.
SaleNo. 2
Horbäach P-5-P Activated Vitamin B6 100mg | 120 Tablets | Vegetarian Supplement, Non-GMO, Gluten Free | Pyridoxal 5 Phosphate | Coenzyme B6
  • P-5-P: Get premium quality and exceptional value from this metabolically active form of vitamin B-6
  • VEGETARIAN FORMULA: Delivers 100 mg of P-5-P in just two easy-to-take tablets
  • EXPERTLY CRAFTED: Our professional formula is backed by our commitment to purity and potency
  • HORBAACH MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
  • NATURALLY FREE OF: Gluten, Wheat, Artificial Flavor, Artificial Sweetener, Preservatives & Non-GMO
SaleNo. 3
Nutricost P5P Vitamin B6 Supplement 50mg, 240 Capsules (Pyridoxal-5-Phosphate) - Vegetarian Friendly, Non-GMO, Gluten Free
  • 50mg Of P5P Per Capsule
  • 240 Servings Per Bottle, 1 Capsule Per Serving
  • Vitamin B6 Supplement (Pyridoxal-5-Phosphate)
  • Vegetarian Friendly, Non-GMO, Gluten Free
  • Made In A GMP Compliant, FDA Registered Facility
No. 4
Nutricost P5P Vitamin B6 Supplement 100mg, 240 Capsules (Pyridoxal-5-Phosphate) - Vegetarian Friendly, Non-GMO, Gluten Free
  • 100mg Of P5P Per Capsule
  • 240 Servings Per Bottle, 1 Capsule Per Serving
  • Vitamin B6 Supplement (Pyridoxal-5-Phosphate)
  • Vegetarian Friendly, Non-GMO, Gluten Free
  • Made In A GMP Compliant, FDA Registered Facility
No. 5
THORNE Pyridoxal 5'-Phosphate - Bioactive Vitamin B6 (Pyridoxine) Supplement for Energy Production and Neurotransmitter Synthesis - 180 Capsules
  • Active B6: The active form of vitamin B6 that is readily used by the body
  • Multiple Functions: An essential cofactor for the synthesis of amino acids and numerous neurotransmitters (brain chemicals)*
  • PMS: Pairs with magnesium for support of women with PMS*
  • Free From: Every Thorne product is made with the purest possible ingredients - without gluten or other major allergens (eggs, tree nuts, peanuts) This product also contains no soy, dairy, shellfish, or fish
  • Thorne's commitment to integrity and science-backed products has helped us earn the trust of thousands of health-care professionals, U.S. National Teams, the Mayo Clinic, and families around the world
No. 6
NatureBell P5P Vitamin B6 100mg Per Serving, 240 Capsules | Activated Pyridoxal 5 Phosphate Supplements – Essential B Vitamins for Brain & Memory Health – Non-GMO
  • Activated Pyridoxal 5’-Phosphate (P5P) capsules 100mg per serving, easily digested and absorbed bioactive vitamin B6 form, essential daily B vitamin micronutrient support, proudly manufactured in the USA.
  • 240 capsules per bottle, 2 capsule serving size, contains 100mg vitamin B6 as activated Pyridoxal 5’-Phosphate (P5P) per dose (50mg per cap), lasts up to 4 months
  • Taking on a daily basis may promote sustainable energy and offer support for a healthy nervous system, mood balance, brain function, and immune response for both men and women.
  • Activated vitamin B6 is the biologically active form that is utilized directly by the body, P5P doesn't need to be converted by the liver which provides efficient use with minimal waste.
  • Authentic non-GMO vitamin B6 (P5P) supplement. Contains pure ingredients free of soy, dairy, gluten, preservatives, wheat, fish, and tree nuts. All products are also 3rd party lab tested for safety and potency.
No. 7
Best Naturals P5P Vitamin B6 (Pyridoxal 5 Phosphate) 100 mg/Serving - 120 Tablets - an Active Form of Vitamin B6.
  • PREMIUM FORMULA - Our P5P Tablets are the made with high quality Pyridoxal 5 Phosphate
  • Supports Healthy Homocysteine Levels & Nervous System Health*
  • 3rd Part Lab Tested - Our All Best Naturals Products come with 3rd Party Independent Lab Tested
  • No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Corn, No Soy, No Egg, No Lactose, No Gluten, No Wheat, No Yeast, No Fish
  • All Best Naturals products are manufactured in accordance with Good Manufacturing Practices (GMP), among the highest standards in the world - Proudly Made in the USA
No. 8
Seeking Health P-5-P (Pyridoxal 5-Phosphate) - Immune Health & Homocysteine Metabolism Support - Support Energy Production with Bioavailable Vitamin B6-25, 100 Capsules
  • Immunity Support Supplement: This vitamin B supplement is packed with 25 mg of vitamin B6 to support your body's immune system
  • Vegetarian Capsules for Metabolism Support: This vitamin B6 supplement with P-5-P supports the healthy metabolism of hormones, homocysteine, sulfur, and amino acids
  • Vitamin B Supplement for Men & Women: This immune support supplement also supports men and women having a healthy mindset and positive outlook on life
  • Allergen-Friendly Immune Support: This pyridoxal 5-phosphate supplement is free of GMOs, gluten, eggs, fish, shellfish, tree nuts, peanuts, wheat, sesame, and soy
  • Optimizing Healthy Living: From research to packaging, Seeking Health prioritizes quality and safety at every step of the production process to provide health support you can trust
No. 9
Vital Nutrients Pyridoxal-5 Phosphate | Activated Vitamin B6 | Methylated B6 for Metabolism, PMS, and Menstrual Support* | High-Potency P5P Supplement | Gluten, Dairy, Soy Free | 90 Capsules
  • Premium, Absorbable P5P: Vital Nutrients P5P is an Active Form of Vitamin B6 (Pyridoxal-5 Phosphate) to support healthy energy metabolism, heart and brain health.
  • PMS Support: This popular vitamin helps with mindset changes, cramps & edema associated with the menstrual cycle.
  • Clean Vegan Formula: Free from gluten, dairy, peanut, tree nut, fish, shellfish, soy, sesame, and egg. Non-GMO. Made without artificial fillers, coatings, binders, or colors.
  • Quality You Can Rely on: Vital Nutrients supplements are manufactured in our allergen-free, NSF-certified Middletown, CT facility. Our rigorous quality assurance program includes third-party independent laboratory testing of raw ingredients and finished products for purity and potency to ensure what’s on the label matches what’s in the bottle.
  • Trusted by Healthcare Practitioners Worldwide: Vital Nutrients was founded 30 years ago by practitioners who set out to make a positive and lasting impact on the health of people and planet. Today, our premium line of clinically relevant, pure, clean-label formulas is trusted by healthcare practitioners and health-conscious consumers worldwide.
No. 10
Country Life P-5-P Vitamin B6 – Bioavailable Pyridoxal-5-Phosphate Supplement for Energy, Nervous System Support, and Red Blood Cell Growth – Certified Gluten Free, Vegan, Non-GMO – 100 Capsules
  • ENERGY PRODUCTION SUPPORT - Contains Pyridoxal-5-Phosphate (P-5-P), the bioactive form of Vitamin B6, which helps metabolize carbohydrates, lipids, and proteins into sustainable energy.
  • BIOAVAILABLE VITAMIN B6 - This supplement is formulated with P-5-P, a highly absorbable form of Vitamin B6, ensuring optimal nutrient absorption and efficacy.
  • SUPPORTS NERVOUS AND IMMUNE SYSTEMS - Our P-5-P Vitamin B6 supplement aids in the function and growth of red blood cells, promoting a healthy nervous system and bolstering immune health.
  • CERTIFIED GLUTEN-FREE & VEGAN - Our Vitamin B6 supplement is certified gluten-free by GFCO, vegan by the AVA, and verified non-GMO by NSF, ensuring it meets your dietary needs.
  • AUTHENTICITY OF INGREDIENTS - We prioritize the purity of our ingredients, ethically sourcing them and performing rigorous laboratory testing to deliver the highest quality product.
No. 11
Designs for Health P-5-P - 50mg Vitamin B6 (P5P Pyridoxal-5-Phosphate) Supplement - Non-GMO, Vegan B-6 (120 Capsules)
  • Bioactive B6 Form - P-5-P is the form of vitamin B6 the body ultimately uses.
  • GABA & Serotonin Support - B6 is necessary for a wide range of actions, including the production of gamma-aminobutyric acid (GABA), for the conversion of 5-HTP to serotonin, and also for the decarboxylation of levodopa to dopamine.
  • Vitamin B6 is also needed for amino acid and lipid metabolism.*
  • Vegan & Non-GMO - This product is Vegetarian and Vegan-Friendly. Made without GMOs, Gluten, Dairy, or Soy.*
  • Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**
No. 12
Swanson P-5-P (Pyridoxal-5-Phosphate) Coenzymated Vitaminb-6 20 Milligrams 60 Capsules
  • Bypasses the conversion process in the liver
  • Goes to work immediately to promote cardiovascular maintenance
  • Non-GMO
  • Per GMP guidelines set forth by the FDA, most products are formulated for 24 months from the date of manufacture. Liquids and probiotics are formulated for 12 months.
SaleNo. 13
Swanson P-5-P (Pyridoxal-5-Phosphate) Coenzymated Vitamin B-6 40 Milligrams 60 Capsules
  • Double strength formula
  • The metabolically active form of vitamin B-6
  • Goes to work immediately to support cardiovascular health
  • Per GMP guidelines set forth by the FDA, most products are formulated for 24 months from the date of manufacture. Liquids and probiotics are formulated for 12 months.
No. 14
Pure Encapsulations P5P 50 - Active Vitamin B6 - Supports Energy Metabolism & Brain Health* - Gluten Free & Non-GMO - 60 Capsules
  • Activated Vitamin B6: Pure Encapsulations P5P 50, an active vitamin B6 dietary supplement form, supports energy metabolism, heart, and brain health*
  • Energy Metabolic Support: Activated vitamin B6 facilitates the release of glycogen used in energy production; balances body fluids*
  • Immune Health Aid: Easy-to-swallow capsules support the production of antibodies and red blood cells*
  • Suggested Use: As a dietary supplement, take 1 non-GMO, gluten free capsule, 1-2 times daily, with meals
  • Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs
No. 15
Source Naturals Coenzymated B-6 25mg P-5 Pyridoxal-5 Phosphate Fast-Acting, Quick Dissolve Sublingual Vitamin Supports Amino Acid Metabolism - 30 Lozenges
  • In order for vitamins to be utilized by the body, they must first be converted into their active coenzyme forms. This Coenzymated B-6 goes directly into your bloodstream in its active form, ready to go to work immediately.
  • Suggested Use: 1 tablet daily.
  • Well Made Supplement: Suitable for vegetarians. Contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance
  • Over 40 Years of Trust. Source Naturals was created in 1982 by CEO Ira Goldberg to support everyone’s potential to enjoy optimal health.
  • Manufactured in the USA. Manufactured in Scotts Valley, CA, under the Good Manufacturing Practices (cGMPs) established by the US Food and Drug Administration. (FDA)
No. 16
Biotics Research B6 Phosphate Biologically Active Form of Vitamin B6 (pyridoxal-5-phosphate), Supports Immune Function, Metabolism, Cardiovascular Health 100 Tablets
  • ENERGY PRODUCTION: P-5-P is widely utilized in central energy production pathways, especially in amino acid biosynthesis and energy production; It functions as a coenzyme in the release of energy from stored glycogen
  • HELPS MAINTAIN LEVELS OF HAPPY BRAIN CHEMICALS: Stored in the liver, muscles and brain, vitamin B6 acts as a cofactor and is involved in more than 100 reactions, including neurotransmitter synthesis; Insufficient levels of B6 can result in low levels of dopamine, serotonin, epinephrine, melatonin, norepinephrine and GABA, neurotransmitters that contribute to positive mood and behavior; Sufficient levels of B6 help maintain healthy levels of neurotransmitters that support health
  • SUPPORTS CARDIOVASCULAR HEALTH: Vitamin B6 regulates the production of homocysteine, a compound that, in excess, can damage the lining of blood vessels both in the heart and brain; Vitamin B6, therefore, supports both cognitive and cardiovascular health
  • WHO WE ARE: We have revolutionized the nutritional supplement industry by combining “The Best of Science and Nature"; Our focus on research, natural effectiveness, product safety, efficacy, quality control, and ongoing innovation drives our advancements in the field
  • QUALITY MADE IN THE USA: We produce tablets, capsules, powders, and liquids in a Texas Department of Health licensed, GMP-certified production and ISO-certified laboratory facility; All products are tested in a state-of-the-art laboratory to ensure safety, efficacy, and purity, and are Gluten Free!
No. 17
Douglas Laboratories Pyridoxal-5-Phosphate (50 mg.) | Vitamin B6 to Support Neurological Health and Cardiovascular System | 60 Capsules
  • Cardiovascular Health: Pyridoxal-5-Phosphate (P5P) is the metabolically active coenzyme of Vitamin B6. Vitamin B6 has been studied for cardiovascular health.*
  • Neurological Health: Vitamin B6 supports neurotransmitter health.*
  • Vitamins/Minerals/Amino Acids: Our vitamins/minerals and amino acid formulas are developed to provide beneficial support in filling nutrient gaps.*
  • Our uncompromising operational practices at our state-of-the-art manufacturing facilities surpass GMP standards and manufacturing regulations. All of our products are GMO-free.
  • For 65 years, Douglas Laboratories has been dedicated to meeting the needs of healthcare professionals. As a globally recognized leader in the development of innovative, science-based nutritional supplements, we strive to help healthcare professionals and their patients push their potential for healthy living, today and in the future.*
No. 18
Klaire Labs P-5-P - 30 Milligrams of Bioactive Vitamin B6 Pyridoxal-5-Phosphate for Metabolic & Liver Support, Hypoallergenic (100 Capsules)
  • The converted and easy-to-assimilate form of vitamin B6.
  • Each vegetarian capsule supplies 30 mg of B6 from pyridoxal 5'-phosphate.
  • This phosphorylated B6 metabolite is a coenzyme in more than 50 different metabolic steps, including amino acid conversions, red blood cell and neurotransmitter production, and fatty acid metabolism.*
  • Hypoallergenic* product free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, corn, and yeast. Contains no artificial colors, flavors, or preservatives.
  • Trusted by healthcare practitioners since 1969, Klaire Labs products are developed closely with physicians and are intended to be used as directed by a healthcare practitioner.
SaleNo. 19
Piping Rock P5P Vitamin B6 | 50mg | 200 Tablets | Pyridoxal 5-Phosphate Supplement | Vegetarian, Non-GMO, Gluten Free
  • Active, Bioavailable Form of B-6
  • Therapeutic Grade
  • Easy-to-Swallow Tablets
  • Non-GMO and Gluten Free
  • Laboratory Tested, using Trusted Ingredients
No. 20
MONOHERB Pyridoxal 5-Phosphate 300 mg - 90 Vegetarian Capsules - P5P Activated Vitamin B6 - Highly Bioavailable
  • Highly Bioavailable Vitamin B6 ( Pyridoxal 5-Phosphate ), 90 SERVING: 90 vegan small capsules (300mg per capsule).
  • HEALTH BENEFITS OF P5P: Stimulate production of gastric HCl.* Provide proper absorption of Vitamin B12 and magnesium.* Helps to release glycogen from the liver and muscles.* Regulates balance of sodium and potassium, which promotes the healthy functioning of the nervous and musculoskeletal systems.*
  • Vegan/Vegetarian, Soy Free, Egg Free, Dairy Free, Nut Free, Made Without Gluten, Non GMO, No Preservatives, No Additives, No Fillers.

How to choose a good vitamin b6 pyridoxal phosphate

Does the idea of finding a fantastic vitamin b6 pyridoxal phosphate make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in vitamin b6 pyridoxal phosphate. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top vitamin b6 pyridoxal phosphate products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top vitamin b6 pyridoxal phosphate on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top vitamin b6 pyridoxal phosphate brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top vitamin b6 pyridoxal phosphate based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the vitamin b6 pyridoxal phosphate were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good vitamin b6 pyridoxal phosphate, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your vitamin b6 pyridoxal phosphate.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting vitamin b6 pyridoxal phosphate for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our vitamin b6 pyridoxal phosphate. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what vitamin b6 pyridoxal phosphate should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on vitamin b6 pyridoxal phosphate.