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The 8 Best flea and tick prevention for dogs of 2025

Are you trying to find flea and tick prevention for dogs among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling flea and tick prevention for dogs on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 20 hours of research and did 16 flea and tick prevention for dogs tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best flea and tick prevention for dogs you can buy today

SaleNo. 1
Frontline Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments
  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
  • Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
  • Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
SaleNo. 2
Flea and Tick Prevention for Dogs Chewables - 170 Chews - Natural Dog Flea and Tick Treatment Chewable - Flea and Tick Chews for Dogs - Soft Oral Flea Pills for Dogs - All Breeds & Ages - Bacon Flavor
  • Natural Flea & Tick Prevention: Defend your dogs from pests the natural way with our flea prevention for dogs - a safer alternative for itch-free protection
  • Optimal Protection: To achieve the best outcomes, administer our chewable flea and tick prevention tablets to your dog on a daily basis. This helps establish the necessary levels in their system for effective protection.
  • Suitable for All Breeds and Ages: Whether you’re caring for a teacup pup or a gentle giant, our flea chews for dogs are designed to keep dogs of all breeds and ages happily protected
  • Veterinarian Formulated & USA Made: Trust in the premium quality of our dog flea & tick control chews, which are formulated by veterinarians and manufactured in the USA within an FDA-registered facility
  • Hassle-Free Administering: Forget the struggle of topical treatments - our tasty chicken-flavored chewables make administering flea and tick prevention a treat, not a chore
SaleNo. 3
PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Large Dogs (45-88 lbs)
  • EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
  • TRUSTED, VET QUALITY* FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours.
  • BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle! Kill flea eggs and larvae to prevent re-infestation.
  • FAST ACTNG LONG-LASTING FLEA AND TICK PROTECTION: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts up to six months.
  • EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with three (3) waterproof topical applications that provides your pet flea protection and control for three (3) months.
No. 4
Seresto Large Dog Vet-Recommended Flea & Tick Treatment & Prevention Collar for Dogs Over 18 lbs. | 8 Months Protection
101,965 Consomer Reviews
Seresto Large Dog Vet-Recommended Flea & Tick Treatment & Prevention Collar for Dogs Over 18 lbs. | 8 Months Protection
  • Vet-recommended, premium flea & tick protection for dogs & puppies without the price tag
  • Long-lasting flea and tick collar kills & repels fleas for 8 continuous months
  • Seresto is the #1 veterinarian recommended flea & tick collar*
  • Starts working within 24 hours to kill & repel fleas by contact so pests don’t have to bite your dog to die
  • Hassle-free, non-greasy, easy-to-use flea & tick protection
SaleNo. 5
Frontline Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments
  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
  • Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
  • Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
SaleNo. 6
K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 1-Mo Supply
  • K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
  • Kills fleas within 12 hours of application
  • Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
  • No prescription needed
No. 7
K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 1-Mo Supply
  • K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
  • Kills fleas within 12 hours of application
  • Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
  • No prescription needed
No. 8
Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 pounds), Unscented, 3 Count (Previously Solimo)
  • Same product, new look – This product is identical in manufacturing and formulation as the Solimo brand
  • One 3 dose pack of Amazon Basics Flea and Tick Treatment for Dogs, Large (45-88 lbs), 3 Count (Previously Solimo)
  • Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
  • Active ingredients Fipronil and (s)-methoprene prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
  • One application provides up to 30 days of protection
  • Waterproof: 24 hours after application your pet’s treatment is protected against rain and water activities
  • Packaging received may vary: you may receive product in Solimo or Amazon Basics packaging
  • Amazon Basics Flea and Tick Topical does not expire
  • Satisfaction Guarantee: We’re proud of our products. If you aren’t satisfied, we’ll refund you for any reason within a year of purchase. 1-877-485-0385
No. 9
K9 Advantix II Medium Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 11-20 lbs. | 1-Mo Supply
30,357 Consomer Reviews
K9 Advantix II Medium Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 11-20 lbs. | 1-Mo Supply
  • K9 Advantix II Medium Dog 30-day treatment & prevention protects dogs 11-20 lbs. from fleas, ticks, mosquitoes, biting flies and lice
  • Kills fleas within 12 hours of application
  • Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
  • No prescription needed
SaleNo. 10
Flea and Tick Prevention for Dogs Chewables - 170 Treats - Natural Dog Flea and Tick Treatment Chewable Supplement - Oral Pills - All Breeds & Ages - Soft Chews - Made in USA
  • Natural Flea & Tick Prevention: Defend your dogs from pests the natural way with our flea prevention for dogs - a safer alternative for itch-free protection
  • Optimal Protection: To achieve the best outcomes, administer our chewable flea and tick prevention tablets to your dog on a daily basis. This helps establish the necessary levels in their system for effective protection.
  • Suitable for All Breeds and Ages: Whether you’re caring for a teacup pup or a gentle giant, our flea chews for dogs are designed to keep dogs of all breeds and ages happily protected
  • Veterinarian Formulated & USA Made: Trust in the premium quality of our dog flea & tick control chews, which are formulated by veterinarians and manufactured in the USA within an FDA-registered facility
  • Hassle-Free Administering: Forget the struggle of topical treatments - our tasty chicken-flavored chewables make administering flea and tick prevention a treat, not a chore
No. 11
Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 pounds), 3 Count (Previously Solimo)
  • Same product, new look - This product is identical in manufacturing and formulation as the Solimo brand
  • One 3 dose pack of Amazon Basics Flea and Tick Treatment for Dogs, Small (5-22 lbs), 3 Count (Previously Solimo)
  • Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
  • Active ingredients Fipronil and (s)-methoprene prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
  • One application provides up to 30 days of protection
  • Waterproof: 24 hours after applicaiton your pet's treatment is protected against rain and water activities
  • Packaging received may vary: you may receive product in Solimo or Amazon Basics Packaging
  • Amazon Basics Flea and Tick Topical does not expire
  • Satisfaction Guarantee: We’re proud of our products. If you aren’t satisfied, we’ll refund you for any reason within a year of purchase. 1-877-485-0385
No. 12
Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment
  • COMPARE TO K9 ADVANTIX II: Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen - the same safe, fast acting active ingredients used in Advantix II for Dogs. Includes 4 monthly doses
  • ACTIVELY PROTECTS YOUR DOG: Activate II is approved by veterinarians to repel and kill fleas and ticks on contact - before your dog is exposed to bites and potential flea borne illnesses
  • STOP INFESTATIONS FAST: Our topical drops prevent infestations by breaking the flea life cycle - our insect growth regulator (IGR) starts killing flea eggs and larvae within 12 hours of application
  • EASY TO APPLY: Simply apply to the base of your dog's neck, and the waterproof solution will travel across the skin - providing continuous protection for 30 days per application
  • MADE IN AMERICA - RESULTS GUARANTEED: TevraPet Activate II is made to the quality standard we demand for our own pets. We're proud to help you protect your dog with confidence
SaleNo. 13
Frontline Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments
  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
  • Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
  • Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
No. 14
Capstar(nitenpyram) for Dogs Fast-Acting Oral Flea Treatment for Dogs 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses
  • Fast-Acting Flea Treatment: CAPSTAR (nitenpyram) starts killing adult fleas in just 30 minutes
  • Tackle Flea Infestations Fast: With one dose of CAPSTAR, you can watch the dead fleas fall off your pet
  • Treat Reinfestations Fast: If your pet gets reinfested with fleas, simply give another dose as often as once a day
  • No Prescription Needed: Fast, effective flea treatment for dogs that's available over the counter
  • Intended Use: CAPSTAR Oral Flea Treatment for Small Dogs (57 mg) is safe for dogs and puppies 4 weeks and older that weigh 2-25 pounds
No. 15
Seresto Small Dog Vet-Recommended Flea & Tick Treatment & Prevention Collar for Dogs Under 18 lbs. | 8 Months Protection
  • Vet-recommended, premium flea & tick protection for dogs & puppies without the price tag
  • Long-lasting flea and tick collar kills & repels fleas for 8 continuous months
  • Seresto is the #1 veterinarian recommended flea & tick collar*
  • Starts working within 24 hours to kill & repel fleas by contact so pests don’t have to bite your dog to die
  • Hassle-free, non-greasy, easy-to-use flea & tick protection
SaleNo. 16
FRONTLINE Shield Flea & Tick Treatment for Large Dogs 41-80 lbs., Count of 3
  • FRONTLINE Shield, from the #1 name in flea and tick protection*, provides proven flea and tick protection with repellency action against ticks and mosquitoes.* Data on file at Boehringer Ingelheim.
  • Kills and repels all stages of ticks, including those that may transmit Lyme disease.
  • Repels mosquitoes that may transmit heartworm disease.
  • Kills chewing lice and adult fleas, flea eggs and larvae to prevent re-infestations.
  • Convenient to use, easy to apply, waterproof formula protects for a full 30 days.
  • For dogs big and small; effective for puppies as young as 9 weeks and weighing at least 5 pounds.
SaleNo. 17
Hartz UltraGuard Dual Action Flea & Tick Topical Dogs & Puppies Treatment & Prevention, 6 Months, 15-30 lbs
  • KILLS FLEAS & TICKS: Kills fleas, flea eggs, deer ticks, and brown dog ticks on contact – it is important for your pup to have a flea and tick prevention treatment all year round!
  • PREVENTS RE-INFESTATION: This topical formula prevents re-infestation by breaking the flea life cycle for up to 30 days.
  • FAST ACTING FULL BODY PROTECTION: Active ingredients spread across the skin using your dog’s natural oil to quickly travel across the coat for full body protection from head to tail.
  • 6 MONTHLY FLEA & TICK TREATMENTS: Contains 6 single dose tubes (1 tube per monthly application) for non-stop protection for up to 6 months. Apply at the base of your dog’s back between the shoulder blades each month.
SaleNo. 18
Flea and Tick Prevention for Dogs Chewables - All Natural Dog Flea & Tick Control - Flea and Tick Chews for Dogs - Oral Flea Pills for Dogs Supplement - All Breeds and Ages - Made in USA - 120 Tablets
  • Natural Flea And Tick Prevention For Dogs: Keep your dog safe from fleas and ticks with our supplement. Our formula uses only natural ingredients to help prevent pesky pests from biting your dog
  • Effective Protection: For the best results, give our flea and tick prevention for dogs chewable tablets to your dog every day, this helps build up the appropriate levels in their system
  • Safe And Natural: Our tick and flea control for dogs is made in the USA using only natural ingredients. It's safe for dogs of all breeds and ages, so you can trust that your furry friend is in good hands
  • Made in The U.S.A, Vet Formulated: Our flea and tick prevention for small dogs treats are made in the USA and formulated by Vets in an FDA-registered facility that meets the highest quality standards
  • Premium Natural Ingredients Give Results: No Added Sugar, Wheat, Corn, Gmo or Preservatives. We are committed to using only best ingredients that deliver results in our flea and tick chewables for dogs
No. 19
PetArmor for Dogs, Flea and Tick Treatment for Extra Large Dogs (89-132 Pounds), Includes 3 Month Supply of Topical Flea Treatments
  • DOG FLEA AND TICK CONTROL: PetArmor topical flea and tick treatment kills adult fleas, ticks and chewing lice. Backed by the PetArmor Protection Guarantee.
  • VET QUALITY FORMULA: Dog flea treatment contains the active ingredient fipronil.
  • FAST-ACTING FLEA TREATMENT: PetArmor flea treatment for dogs can help you stop an existing flea or tick infestation.
  • FLEA AND TICK PREVENTION: PetArmor for dogs helps you protect your furry family member from brown dog ticks, American dog ticks, lone star ticks, and deer ticks (which may transmit Lyme disease).
  • INCLUDES: Three (3) topical application tubes for a 3 month supply of dog and flea and tick control. For best results, apply flea & tick treatment for dogs directly to dry skin on your dog's back-between the shoulder blades-on a monthly basis.
SaleNo. 20
Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 lbs), 3 Count (Previously Solimo)
4,984 Consomer Reviews
Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 lbs), 3 Count (Previously Solimo)
  • Same product, new look―This product is identical in manufacturing and formulation as the Solimo brand
  • One 3 dose pack of Amazon Basics Flea and Tick Treatment for Dogs, Medium (23-44 lbs), 3 Count (Previously Solimo)
  • Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment.
  • Active ingredients (list ingredients) prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice.
  • One application provides up to 30 days of protection.
  • Waterproof: 24 hours after application your pet’s treatment is protected against rain and water activities
  • Packaging received may vary: you may receive product in Solimo or Amazon Basics Packaging.
  • Amazon Basics Flea and Tick Topical does not expire
  • Satisfaction Guarantee: We’re proud of our products. If you aren’t satisfied, we’ll refund you for any reason within a year of purchase. 1-877-485-0385

How to choose a good flea and tick prevention for dogs

Does the idea of finding a fantastic flea and tick prevention for dogs make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in flea and tick prevention for dogs. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top flea and tick prevention for dogs products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top flea and tick prevention for dogs on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top flea and tick prevention for dogs brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top flea and tick prevention for dogs based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the flea and tick prevention for dogs were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good flea and tick prevention for dogs, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your flea and tick prevention for dogs.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting flea and tick prevention for dogs for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our flea and tick prevention for dogs. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what flea and tick prevention for dogs should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on flea and tick prevention for dogs.