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The 8 Best cold sore and fever blister treatments of 2024

Are you trying to find cold sore and fever blister treatments among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling cold sore and fever blister treatments on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 21 hours of research and did 19 cold sore and fever blister treatments tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best cold sore and fever blister treatments you can buy today

SaleNo. 1
Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2
  • Number 1 Cold Sore Brand: Two 0.07 oz tubes of Abreva 10 Percent Docosanol Cold Sore Treatment
  • Can Heal in 2.5 Days: Fever blister cream contains 10 percent docosanol to shorten the duration of cold sore symptoms (1)
  • Nothing Heals Fever Blisters Faster: 10 percent docosanol cream penetrates deep into skin to tackle cold sores at their source (1, 2, 3)
  • Lip Cream Clinically Proven to Shorten Duration of Symptoms: Cold sore product shortens duration of tingling, pain, burning and itching associated with cold sores (1)
  • Portable Cold Sore Cream: Packaged in a convenient tube for on the go cold sore treatment
  • Number 1 Dermatologist Recommended Cold Sore Treatment: Abreva Cream is a nonprescription cold sore medicine that shortens healing time (1)
  • HSA and FSA eligible product
No. 2
Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count
  • FAST HEALING ultra-thin Hydrocolloid Gel provides a moist environment to help: relieve pain, reduce the blistering and prevent scabbing.
SaleNo. 3
TARO Cold Sore/Fever Blister Treatment - Docosanol 10% Cream (0.07 oz - 2 Tube)
  • Docosanol Cream 10% – Treats cold sores/fever blisters
  • Treats Cold Sores / Fever Blisters on the Face or Lips
  • Shortens Healing Time and duration of Symptoms
SaleNo. 4
TARO Cold Sore/Fever Blister Treatment - Docosanol 10% Cream (0.07 oz - 1 Tube)
  • Docosanol Cream 10% – Treats cold sores/fever blisters
  • Treats Cold Sores / Fever Blisters on the Face or Lips
  • Shortens Healing Time and duration of Symptoms
SaleNo. 5
Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz
  • Trusted: A favorite for cold sore and fever blister treatment for lips for over 130 years.
  • Instant Relief: Formulated with camphor and phenol to temporarily inactivate the pain signals at the nerve endings in the skin to provide a local anesthetic (numbing effect) that stops the pain and itch of cold sores and fever blisters on contact.
  • Helps Prevent Infection: Antiseptic properties help prevent infection to promote cold sore healing.
  • Aloe Soothes and Moisturizes: Prevents dryness and cracking as cold sores and fever blisters dry out.
  • Store at room temperature
SaleNo. 6
Abreva Docosanol 10 Percent Cream Cold Sore Treatment, Fever Blister and Cold Sore Cream - 0.07 Oz
  • One tube of cream
  • Relieves itching and burning
  • Portable tube
  • Temporary relief
  • Easy to apply
SaleNo. 7
Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Pump
  • Number 1 Cold Sore Brand: One 0.07 oz pump bottle of Abreva 10% Docosanol Cold Sore Treatment
  • Can Heal in 2.5 Days: Fever blister smooth, white cream contains 10% docosanol to shorten the duration of cold sore symptoms (1) by blocking the virus from infecting healthy cells
  • Nothing Heals Fever Blisters Faster: Scientifically-proven medicine to shorten cold sore healing time
  • Lip Cream Clinically Proven to Shorten Duration of Symptoms: Cold sore product shortens duration of tingling, pain, burning and itching associated with cold sores (1)
  • Portable Cold Sore Cream: Packaged in a convenient pump bottle for on the go cold sore treatment
  • Number 1 Dermatologist Recommended Cold Sore Treatment: Abreva Cream is a nonprescription cold sore medicine that shortens healing time (1)
  • HSA and FSA eligible product
SaleNo. 8
Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz
  • HALVE YOUR HEALING TIME - Cut cold sore healing time by 50% with the power of L-Lysine, a scientifically researched amino acid that inhibits arginine activity, nourishes skin and accelerates recovery.
  • FAST-ACTING PAIN & ITCH RELIEF - Experience rapid relief from cold sore pain, burning, and itching discomfort with the cooling effect of Menthol plus 14 herbal ingredients to soothe and nourish your skin.
  • HERBAL LIP TREATMENT - Harness the power of our nutrient-rich formula with Calendula, Vitamin E, and Propolis, providing deep moisturization and skin-nourishing properties for overall lip health.
  • DISCREET COMFORT - Invisible balm can be worn under lipstick or gloss without worry, doesn't burn upon application, and offers relief from tingling, itching, burning, and other discomforts associated with cold sores.
  • ROUND OUT YOUR LIP CARE ROUTINE - For optimal results use Lysine+ Ointment with our Super Lysine Immune Support Tablets and Lip Clear Invisible Cold Sore Patch to calm cold sores and promote faster healing.
SaleNo. 9
Herpecin-L Pain Relief Triple Action with Lidocaine Cold Sore and Fever Blister Treatment, 0.15 oz
  • Triple Action spot treatment instantly numbs cold sore and fever blister pain & itch, protects against infection, and helps prevent cracking
  • Maximum strength lidocaine targets and numbs cold sore pain & itch right at the source and starts working on contact
  • A soothing skin protectant helps prevent painful cracking and re-opening while keeping the cold sore moisturized
  • Maximum strength antiseptic helps keep the cold sore from getting infected
  • No burning, No irritation, Goes on clear
No. 10
Herpecin L Lip Balm Stick 30 SPF 0.1 Ounce Tube Cold Sore Sun & Fever Blisters and Chapped Lips Relief Lip Balm with SPF30 and Lysine
  • HERPECIN L LIP BALM: Herpecin L Everyday Protection helps relieve and protect against cold sores, fever blisters, and chapped lips. It's formulated with lysine, Vitamins C, B6, and E, lemon balm and added SPF 30 protection.
  • PROTECT AND TREAT YOUR LIPS: Treat your lips to soothing relief from dryness, sun blisters, and cold sores with Herpecin L. Find real relief from herpes related cold sores from real medicine, and protect your lips with Herpecin L lip balm with SPF 30.
  • REAL RELIEF FROM REAL MEDICINE: Herpecin L soothes, moisturizes & creates a SPF 30 barrier to protect your lips against the sun's harmful UV rays. It does more for a cold sore.
  • SPF 30 PROTECTION: UV rays can increase your risk of sun cancer, chapped lips, early skin aging & damaged skin can promote the development of cold sores. Herpecin L lip balm can help prevent sunburn.
  • HERPECIN L FOR COLD SORES: Uniquely formulated with dimethicone & lysine, Herpecin helps relieve & protect painful cracking of lips & promotes healing of cold sores without numbing or drying.
No. 11
Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams
  • One tube of Abreva Cold Sore Rapid Pain Relief, 3 grams
  • Shortens duration of tingling, pain, burning and itching
  • Easy applicable tube form for on-the-go use
SaleNo. 12
Abreva 10 Percent Docosanol Cold Sore Treatment, Fever Blister and Cold Sore Cream - 0.07 oz plus ChapStick Moisturizer Original Lip Balm - 0.15 oz Value Pack
1,861 Consomer Reviews
Abreva 10 Percent Docosanol Cold Sore Treatment, Fever Blister and Cold Sore Cream - 0.07 oz plus ChapStick Moisturizer Original Lip Balm - 0.15 oz Value Pack
  • Lip Balm and Cold Sore Treatment for Lips: One 0.07 oz pump bottle of Abreva 10 Percent Docosanol Cold Sore Cream and one 0.15 oz tube of ChapStick Moisturizer Original Lip Balm Value Pack
  • Abreva Can Heal in 2.5 Days: Fever blister cream contains 10 percent docosanol to shorten the duration of cold sore symptoms (1)
  • Abreva Heals Faster: Abreva docosanol cream cold sore treatment penetrates deep into skin to tackle cold sores at their source (1, 2, 3)
  • Hydrating Lip Care: ChapStick Original Moisturizer Lip Balm delivers up to eight hours of hydration and has seven moisturizing ingredients, plus SPF 15
  • SPF 15: ChapStick lip moisturizer formula provides SPF 15 sun protection
  • Scientifically-Proven Abreva Cold Sore Treatment: Abreva fever blisters cream shortens duration of tingling, pain, burning and itching associated with cold sores (1)
  • Convenient Product: Abreva is packaged in a convenient pump bottle for on the go cold sore treatment; ChapStick moisturizing lip balm comes in a convenient tube for lip care on-the-go
No. 13
Wellness Basics - Cold Sore/Fever Blister Treatment - Docosanol 10% Cream (0.07 oz - 1 Tube) - Non-Prescription Medicine to Shorten Healing Time
  • DOCOSANOL CREAM 10% – Treats cold sores/fever blisters on face or lips. Shortens the healing time and duration of cold sore symptoms.
  • APPLY AT FIRST SIGNS - Tackle cold sores head on. Use at first signs of symptoms for a faster recovery.
  • SHORTEN HEALING TIME – This non-prescription cold sore medicine can be used five times a day until the cold sore is healed.
  • HELP ON THE GO – Convenient sized packaging means you can treat cold sores on the go.
  • Compare to the Active Ingredient in leading national brand
SaleNo. 14
Abreva Cold Sore/Fever Blister Treatment, Pump 0.07 oz (2 g) (Abreva Pump)
1,547 Consomer Reviews
Abreva Cold Sore/Fever Blister Treatment, Pump 0.07 oz (2 g) (Abreva Pump)
  • Country of origin is United States
  • Docosanol 10% - cold sore/fever blister treatment
  • Number of items: 1
  • Package Weight: 0.023 kilograms
SaleNo. 15
Abreva Cold Sore Treatment .07 Oz
  • Abreva for cold sores
  • Country of origin is United States
  • Item Package Dimension: 3.302cm L x 11.43cm W x 13.462cm H
  • Model Number: 2216364
SaleNo. 16
Orajel Touch Free Cold Sore Treatment .12oz, Liquid Formula, Provides Immediate & Targeted Pain Relief, Bonus Size, 6 Applicators.
  • TOUCH- FREE APPLICATOR: Unique application system is designed so you don’t have to touch your cold sore or fever blister with your fingers. Use the applicator to apply our treatment right where you need it most.
  • RELIEVES PAIN* & ITCHING: Orajel Cold Sore Treatment numbs the area of your cold sore to help reduce pain and itching. *For temporary topical pain relief.
  • DISINFECTS: One of a kind formula is designed to clean the area of the cold sore, to disinfect, as well as provide immediate, targeted pain relief.
  • NVISIBLE & QUICK DRYING: Our formula is clear, leaving no residue behind, and a quick drying treatment for your cold sore.
  • From the #1 Oral Pain Reliever Brand for Adults.
No. 17
Forces of Nature Cold Sore Treatment Extra Strength Organic H-Balm, 0.37 Fl Oz, Fast-Acting Canker Sore & Fever Blister Homeopathic Medicine with Soothing Essential Oils, Non GMO
  • EXTRA STRENGTH HEALING BALM: Formulated to help alleviate itching, burning, tingling and discomfort, H-Balm is an effective remedy for a canker sore, cold sore and shingles. Specifically targets uncomfortable fever blisters
  • HOMEOPATHIC & NATURAL MEDICINE: Our natural blister balm combines Echinacea, Sodium Chloride, Northern White Cedar and Marigold, with a blend of therapeutic essential oils. Provides long lasting and soothing relief
  • OUTBREAK PREVENTION: This homeopathic medicine offers systemic support for fever blister prevention. Our carefully crafted blend gives immune support, helping you stay resilient against future cold sore and canker sore outbreaks
  • FAST-ABSORBING FORMULA: Our blister care extra strength formula is a one-two punch against outbreaks, helping rejuvenate damaged skin and reducing flare-ups. Apply 2-3 drops on a moistened swab and dab on the problem area 3-4 times daily
  • WHY WE'RE DIFFERENT: We strive to provide safe, organic remedies for families in search of a healthier solution to their health needs.
No. 18
Cold Sore Shield Daily Cold Sore Supplement. Immune Support Lip Blister & Cold Sore with L Lysine - Don't let a Cold Sore Ruin Your Moment!!
  • DON'T LET A COLD SORE RUIN YOUR MOMENT!: Take daily (for best results) or start taking a few weeks before an important date, presentation, travel, or any other stressful event that you have experienced cold sores in the past.
  • POWERFUL INGREDIENTS: Combination of potent immune supporting nutrients including zinc, selenium, vitamin C, L lysine and more. All made and manufactured in the U.S.A
  • IMMUNE SYSTEM BOOST: Cold sore shield's cold sore treatment works with the body's immune system for around the clock daily support.*
  • DAILY SUPPLEMENT: Take daily, or just weeks before a stressful event, important date, travel etc where you have experienced outbreaks in the past.
  • BUY WITH CONFIDENCE: Buy our product worry free! If our product does not meet your expectations, simply return it! Manufactured in the U.SA
SaleNo. 19
Wellness Basics - Cold Sore/Fever Blister Treatment - Docosanol 10% Cream (0.07oz - Pump) Non-Prescription Medicine to Shorten Healing Time
  • DOCOSANOL CREAM 10% – Treats cold sores/fever blisters on face or lips. Shortens the healing time and duration of cold sore symptoms.
  • APPLY AT FIRST SIGNS - Tackle cold sores head on. Use at first signs of symptoms for a faster recovery.
  • SHORTEN HEALING TIME – This non-prescription cold sore medicine can be used five times a day until the cold sore is healed.
  • HELP ON THE GO – Convenient sized packaging means you can treat cold sores on the go.
  • Compare to the Active Ingredient in leading national brand
No. 20
Cold Sore Treatment for Lips - Lysine Supercharged with Acidophilus Probiotic & Lactobacillus Rhamnosus + Vitamin C for Lip and Skin Health - Immune Support for Effective Prevention and Clear Skin
  • HELP FOR RECURRING COLD SORES - Clear Lip and Skin Health is a specially formulated probiotic blend with key ingredients like lysine and vitamin C that helps to prevent the overproduction of arginine in the body. Arginine is known as a common trigger for lip and mouth blisters, as well as other issues.
  • SUPPORTS SKIN & LIP HEALTH - Did you know that cold sores and blisters around your mouth can be the result of a bacterial imbalance in your gut? Our scientifically researched probiotic strains are paired with a prebiotic blend with lysine, formulated to balance out the bacteria most often responsible for these outbreaks.
  • SCIENTIFICALLY SELECTED STRAINS FOR SKIN & GUT MICROBIOME BALANCE - Clear Lip and Skin Health promotes healthy, clear lips and skin and GI tract health. Ease bloating and balance digestion to help maintain regularity, while improving your skin health from the inside out.
  • POWERFUL INGREDIENTS TO FIGHT OUTBREAKS - Our powerful formula contains key ingredients like vitamin C and lysine which are designed to improve immune function, and balance digestion. Balance the gut and minimize the production of the amino acid most associated with mouth and lip blisters.
  • CONTINUES TO IMPROVE - Clear Wellness 360 stands for full transparency with proven formulas using ingredients in clinically studied doses. The best results come with consistent daily use over months or longer. Our Vegan, Non-GMO formulas are 3rd party tested for purity, potency, and safety. No artificial flavors, fillers, or colors.
  • MONEY-BACK GUARANTEE: If you have any challenges using Clear Probiotics Supplements, reach out anytime for help from our healthcare experts. We'll respond ASAP! If you're not totally satisfied, we will refund you in full.

How to choose a good cold sore and fever blister treatments

Does the idea of finding a fantastic cold sore and fever blister treatments make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in cold sore and fever blister treatments. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top cold sore and fever blister treatments products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top cold sore and fever blister treatments on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top cold sore and fever blister treatments brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top cold sore and fever blister treatments based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the cold sore and fever blister treatments were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good cold sore and fever blister treatments, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your cold sore and fever blister treatments.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting cold sore and fever blister treatments for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our cold sore and fever blister treatments. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what cold sore and fever blister treatments should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on cold sore and fever blister treatments.