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The 8 Best multi enzymes nutritional supplements of 2025

Are you trying to find multi enzymes nutritional supplements among various brands on the market but aren’t sure where to begin? To assist you in finding the right one, we’ve put together a list of the 7 best to help you pick the perfect one!

We investigated and evaluated a number of the top-selling multi enzymes nutritional supplements on the market in order to create our list of the best. Making a decision among the many options available is never simple. There are an infinite number of models available, each with a distinct price. And as you’ll find out, the best options aren’t usually the ones you imagine! This comparison is rich and relevant because of the numerous factors that were employed. You will find products featured in this ranking not only based on their pricing but also on their features and other customers reviews. To write this review, we completed 23 hours of research and did 71 multi enzymes nutritional supplements tests. You won’t need to pick products at random any more. If you’re unsure of what to look for, browse our list and consult the buying guide!

An overview of our top picks

Table of contents

The best multi enzymes nutritional supplements you can buy today

No. 1
Digestive Enzymes with Probiotics - Multi Enzyme Nutritional Supplement - Acidophilus Bromelain Papaya Papain Lipase & Lactase - Improve Digestion - 120 Pills - Arazo Nutrition
  • Eases gas & bloat; Alpha Galactosidase is shown to break down food without spiking glycemic index
  • Break down oily & meat-heavy meals; 9 vital ingredients including Makzyme-Pro work quickly and effectively to ease bloat and gas of big oily meals
  • No more fatigue; breaks down all food types faster, saving energy from digesting, boosting energy
  • Reliable; made in a GMP certified facility in America and third party safety tested for purity
  • High standard; trusted for ingredient safety, nutritional value and label accuracy
SaleNo. 2
NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules
  • SUPPORTS HEALTHY DIGESTION*: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion.* Take one capsule with a meal
  • BREAKS DOWN FATS, CARBS, AND PROTEINS*/OPTIMIZES NUTRIENT AVAILABILITY*: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein*
  • CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
  • Packaged in the USA by a family owned and operated company since 1968
No. 3
Multi Enzyme - Helps Support The Digestion & Absorption of Protein, Carbs & Fat (300 Tablets) by The Vitamin Shoppe
  • Speciality Protein tablet with Carbohydrates that supports Fat Digestion
  • Does Not Contain: Yeast, Wheat, Gluten, Soy, Citrus, Dairy, Fish, Artificial Colors or Flavors.
  • Directions: As a dietary supplement, take two (2) tablets after each meal. Do not take on an empty stomach.
  • Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions. KEEP OUT OF REACH OF CHILDREN.
  • 150 Servings
SaleNo. 4
Hallelujah Diet - Digestive Enzymes, Multi-Enzyme Nutritional Supplements for Dietary Support & Nutrient Absorption, 90 Capsules
  • POWERFUL DIGESTIVE SUPPORT: Hallelujah Diet Digestive Enzymes are designed to help your body break down and assimilate the food you eat, allowing you to get the most out of your diet while supporting healthy body function and optimal energy levels
  • PROMOTE NUTRIENT ABSORPTION: Our extra-strength formula contains cellulase to break down plant fiber so you get maximum nutrient absorption from whole, plant-based foods and can supplement the enzymes that are destroyed from cooked or processed foods
  • BEAT BLOAT & DISCOMFORT: Our supplements can promote proper digestion and help break down nutrients, such as proteins, fats, and carbohydrates, preventing inflammation, bloat, gas, discomfort, and digestive stress
  • A QUICK & CONVENIENT BOOST: Each bottle contains 45 servings of convenient, easy-to-swallow capsules that can be taken twice daily; Our gluten-free, vegan supplements are a quick way to power up your living cells with nutritional energy
  • INNOVATIVE ENZYME BLEND: Our digestive enzymes feature a unique, proprietary blend of pure, nourishing ingredients including chromium, manganese, beetroot powder, kelp algae, zinc, calcium, magnesium, amylase, lipase, lactase, and more
No. 5
Multi Digestive Enzymes with Ox Bile Supplement - Clinical Strength Digestion Supplement with Pancreatin Pancreatic Enzymes for Protein Carb & Fat Digestive Support & Reduced Stomach Discomfort
  • Professional Formula: We are proud to offer our ox bile digestive enzymes blend with a variety of amylolytic, lipolytic & proteolytic enzymes which help break down food into easily digestible forms
  • Elevate your Health: Improve your digestive health with a broad spectrum formula that not only breaks down food but also supports nutrient absorption and can help reduce uncomfortable bloating
  • Anabolic Advantage: Unlike generic digestive enzyme supplements we offer a unique complex of Protease Amylase Lipase with Ox bile extract Betaine HCL with Pepsin Diastase and Papain
  • Trusted Name Since 1924: Anabolic Laboratories has been committed to providing the highest quality nutritional products for 100 years and counting including our clinical pancreatic enzyme supplements
  • Guaranteed Potent and Pure: You can rest assured knowing you have a premium product with Anabolic Labs as all of our supplements are cGMP made in our NPA and FDA inspected American labs
No. 6
Digestive Enzymes with Probiotics - Probiotic Multi Enzymes with Probiotics and Prebiotics for Digestive Health and Bloating Relief for Women and Men, Daily Enzymes for Gut & Digestion - 120 Capsules
  • Ultra Digestive Enzymes: Offers comprehensive digestive support, efficiently breaking down proteins, fats, and carbohydrates for optimal nutrient absorption with our proprietary Makzyme blend
  • Best Digestive Enzymes for Comfort Support: Catering to both women and men, this extra-strength digestive enzyme formula effectively supports common digestive issues such as gas, bloating, and indigestion
  • Essential Enzymes Digestive Support: Formulated with essential enzymes for comprehensive digestive support, ideal for supporting digestive and gut health
  • Trusted Formula: Our digestive enzymes with probiotics are formulated following strict cGMP guidelines; Our digestive enzymes blend is third party tested to assure the quality and purity of each batch
  • Digestion Supplements for Women and Men: Enzymes for Digestive Support with papaya lactobacillus lipase amylase pre prebiotic prebiotics probiotic probioticos probiotics 30 60 action advantage best bifidobacterium bile billion bio biotics bloat bloating bromelain capsules chewable choice complete constipation daily debloat digest digestivas digestive dynamic emzymes enzimas enzyme enzymes fiber gas gb similar to gummies gummy pills vitamins gut health mens morning multi nature natures nutrition plus seed stomach super supplement supports with womens
No. 7
Carlyle Digestive Enzymes | with Probiotics & Prebiotics | 180 Capsules | Non-GMO and Gluten Free Supplement for Men & Women
  • DIGESTIVE ENZYMES: Get full spectrum digestive support from a range of enzymes plus probiotics & prebiotics*
  • SUPER CONVENIENT: Simply take two capsules before or after meals for maximum support
  • ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living
  • CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
  • FREE OF: Gluten, Wheat, Soy, Artificial Color, Artificial Flavor, Preservatives & Non-GMO
No. 8
Codeage Fermented Digestive Enzymes Supplement 3-Month Supply - 14 Digestive Enzymes, Probiotics, Prebiotics, Fermented Botanicals, Plant-Based Multi Pancreatic Enzymes - 1 Capsule a Day - 90 Capsules
  • Comprehensive Enzyme Blend: Codeage Fermented Digestive Enzymes+ supplement offers 14 different digestive enzymes, including protease, amylase, glucoamylase, diastase, invertase, pectinase, cellulase, hemicellulase, xylanase, lipase, phytase, lactase, alpha-galactosidase, and beta-glucanase—all in one convenient capsule.
  • Organic Fermented Botanicals: This digestive enzyme supplement features a fermented organic botanical blend with apple cider vinegar, ginger, kiwi, and turmeric powders, adding additional ingredients to your daily regimen.
  • Probiotics Included: This pancreatic enzymes supplement contains a probiotic blend with four different strains—Bacillus clausii, Bacillus subtilis, Bacillus coagulans, and Saccharomyces boulardii—complementing the enzyme formula.
  • 3-Month Supply: Each bottle of this probiotic enzyme supplement contains 90 servings for three months of supply. This stomach enzymes formula is vegan, non-GMO, soy, dairy, and gluten-free. It is also free of egg, wheat, shellfish, color additives, or preservatives. Capsules can be opened and added to food or drink for versatility.
  • Manufactured in the USA: Codeage Digestive Enzymes supplement is manufactured in the USA with global ingredients in a cGMP-certified facility for quality and purity.
No. 9
310 Nutrition Digestive Enzyme (90CT) | Multi-Enzyme with Lactase to Help Support Body's Digestion | Provides Support for Digestive Comfort from Bloating
  • GAS, BLOATING & STOMACH DISCOMFORT – This supplement features enzyme ingredients such as Papain and Amylase, along with Lactase, Protease and Lactase to support in easing discomfort.**New Look, Same Amazing Products Inside! *Note that we will still be shipping out our previously-branded packaging until we have fully transitioned!*
  • AIDS HEALTHY DIGESTION: 310 Digestive Enzymes help break down proteins, starches and fats to help ease digestion and let your body reap the benefits of the nutrients.
  • NUTRIENTS YOU NEED THROUGHOUT YOUR DAY: Modern day farming methods have left our soils lacking in the vitamins and minerals that we need, so you might be missing out on daily nutrients even if we eat very healthy diets.
  • YOUR BODY, YOUR GOALS: Taking 310 Digestive Enzymes,can help support your metabolism, help you feel energized and help you reach your goals!
  • BREAK DOWN THAT FOOD: 310 Digestive Enzymes are scientifically-designed to act as catalysts, to assist your body’s natural ability to break down foods into amino acids, fatty acids and simple sugars that your body can easily use.
No. 10
Enzyme Nutrition - Two Daily Multi-Vitamin, 100% Whole Food Nutrition, 60 Capsules
  • WHOLE FOOD FOR THE WHOLE FAMILY: Enzyme Nutrition Two Daily contains Enzyme Activated Nutrients (EAN) as part of a whole food matrix. It is personalized to meet the unique needs of every member of the family, 14 years of age and older.
  • HIGH POTENCY ENZYMES: Each ingredient is grown to preserve the highest potency of enzymes contained within the food structure. Additional enzyme blends enhance the utilization of vitamins and minerals, ensuring the products are easily digestible.
  • EXCLUSIVE THERA-BLEND: Thera-blend is an exclusive process that combines multiple strains of enzymes that work in various pH levels, resulting in superior performance in the body.
  • FREE OF: Rest assured knowing that this product does not contain any egg, dairy, preservatives, salt, sucrose, soy, wheat, nuts, corn, gluten, casein, potato, rice, or any artificial colors or flavors.
  • QUALITY + EXPERIENCE: Enzymedica was founded in 1998 with the purpose of offering our customers the highest-potency enzyme products possible. Our goal of educating people about the importance of enzymes in overall health is what motivates Enzymedica. All of our products are made from only the highest quality enzymes and contain absolutely no fillers to ensure purity. Every product is 100% vegetarian, and we seek out vegan and Kosher ingredients whenever possible.
No. 11
Multi Enzyme - Helps Support The Digestion & Absorption of Protein, Carbs & Fat (100 Tablets) by The Vitamin Shoppe
  • Speciality Protein tablet with Carbohydrates that supports Fat Digestion
  • Does Not Contain: Yeast, Wheat, Gluten, Soy, Citrus, Dairy, Fish, Artificial Colors or Flavors.
  • Directions: As a dietary supplement, take two (2) tablets after each meal. Do not take on an empty stomach.
  • Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions. KEEP OUT OF REACH OF CHILDREN.
  • 50 Servings
No. 12
Pure Encapsulations Digestive Enzymes Ultra with Betaine HCl - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 180 Capsules
  • Nutrient Absorption: Contains a mixture of vegetarian enzymes developed to support nutrient bioavailability and absorption; supports digestion*
  • Supports Digestion: Facilitates the normal breakdown of proteins, peptides, polysaccharides, and disaccharides; assists with dairy, fiber, and protein digestion*
  • Digestive Enzymes: Offers a broad-spectrum combination of vegetarian digestive enzymes designed to provide optimal activity across a wide pH range
  • Enhanced Enzyme Blend: Experience enhanced digestion aid with Betaine HCI; supports optimal gastric pH for normal breakdown of many food types*
  • Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs
No. 13
Enzymedica Digest Gold + ATPro, Maximum Strength Enzyme Formula, Prevents Bloating and Gas, 14 Key Enzymes Including Amylase, Protease, Lipase and Lactase, 120 Capsules
  • For Food Lovers: Savor your favorite dishes worry-free; Our full-strength, bloat-busting digestive enzyme blend helps break down large meals faster, easing bloating and occasional indigestion for care-free indulgence*
  • ATPro Blend: Beat the post-meal blues and feel fueled with energy to power through your day; This unique formula features ATPro, a proprietary blend of ATP, Magnesium Citrate, Phytase and CoQ10 that helps fuel your body's cells*
  • Effective All the Way Through: Our proprietary Thera-blend enzymes are formulated for optimal activity throughout the digestive system's varying pH levels, providing faster relief and maximum digestive support*
  • Dosage: Just 1 capsule daily breaks down up to 34g fat, 16g protein and 86g carbs; Contains no gluten, milk, casein, soy, egg, artificial colors, flavors, or GMOs; Vegan, Kosher and Clean Label Project Certified
  • Making a Difference: Enzymedica products harness the power of the finest natural ingredients for maximum effectiveness; We create quality products without compromise while championing initiatives that support the well-being of people and our planet
No. 14
VITÄLZYM Proteolytic Systemic Enzymes Liquid Gel Capsules with Serrapeptase, Immune and Joint Support, Natural Ache Relief Plus Fertility Supplement (360 Capsules)
  • Enteric Coated Advanced Delivery Method: Vitalzym high potency gel caps are unlike any tablet or powder based enzyme product available on the market today. Our formula contains no gluten, yeast or dairy and is designed to ensure maximum absorption into the bloodstream where it is then dispersed via your circulatory system throughout your body
  • Ingredients: Vitalzym Extra Strength premium softgels are the original, all-natural, vegetarian multi enzyme complex. Vitalzym was designed using a scientific research process to identify nature’s miracle ingredients that include Serrapeptase, Bromelain, Papain, Rutin, Amylase, Protease, Lipase and Amla Extract
  • Protect Your Health: Living well in modern times can be stressful and a source of pain at times. Vitalzym contains the most effective, purified vegan-based enzyme blend to promote healing, human bodily functions and leave you feeling clear and fresh
  • Small, Easy To Swallow Gel Caps: Our advanced encapsulations deliver reliable results that offer pure, potent enzymes with reliable consistency and unrivaled absorption rates. Due to the highly effective delivery rate most people need a smaller dosage, and less doses per day
  • Made In Japan: Created by a team of international scientists, Vitalzym works best when combined with exercise, proper fluid intake, and a healthy diet. It is important to be mindful of all aspects of your health. When used properly, Vitalzym can assist with cardio, lung, and immune response as well as provide joint, inflammation support and much more
No. 15
Enzymedica, Enzyme Nutrition Women's 50+ Multivitamin, Supports Immune and Heart Health, 60 Capsules
  • Whole food multi-vitamin + probiotics: Women’s 50+ whole food-based nutrition plus enzymes and potent, shelf-stable probiotics
  • Formulated for women 50+: Iron-free formula supports women’s vibrant health with nutrients that promote bone, breast, and hormone health plus radiant hair, skin, and nails
  • Women's vitality: Power-packed multivitamin formula fuels energy with B vitamins, antioxidants, and phytonutrients to promote lifelong well-being for women
  • Easy-to-digest: Beat the bloat with Thera-blend digestive enzymes plus nutrients from raw fruits, vegetables, superfoods, and probiotic cultures; easy to digest even on an empty stomach
  • Purity promise: Vegetarian and contains no gluten, milk, casein, soy, egg, artificial colors, flavors, or GMOs
No. 16
Inspired Nutrition Bio-Fibrin ® Supplement - Multi Enzyme - Fibrin Defense Proteolytic Enzymes - 150 Capsules
  • Multi-Enzyme Formula - Our formula contains five of the best proteolytic enzymes. These powerful enzymes can help your body manage excess fibrin.
  • Supports Healthy Internal Scar Tissue Function - Bio-Fibrin can support your body in breaking down and dissolving internal scar tissue, promoting the wellness of tissues & organs.
  • Breaks Down Biofilms & Cysts - The ingredients in Bio-Fibrin can help dissolve biofilms and cysts, promoting immune defense and improving overall health.
  • Serrapeptase and Nattokinase - Two enzymes in our BioFibrin blend are among the most powerful proteolytic enzymes that help the body dissolve proteins.
  • Highest Quality. Third-party tested. Non-GMO. Vegan. Made in a certified GMP facility.
No. 17
Supplements with 13 Vitamins & Herbs - Folic Acid, Vitamins C B6 & B12, Hawthorn Olive Leaf Garlic Hibiscus, 90 Capsule
948 Consomer Reviews
Supplements with 13 Vitamins & Herbs - Folic Acid, Vitamins C B6 & B12, Hawthorn Olive Leaf Garlic Hibiscus, 90 Capsule
  • NATURAL SUPPLEMENTS*
  • NATURAL BP SUPPORT SUPPLEMENT FOR WOMEN & MEN
  • HERBAL HEALTH SUPPLEMENT:
  • MADE IN USA
  • PREMIUM QUALITY, SAFE, & POTENT
No. 18
Gut Fix: Discover the herbal remedies, diet tips, and supplements clinically shown to heal your gut (Gut and Hormone Health Series)
  • Amazon Kindle Edition
  • Moretti, Heidi (Author)
  • English (Publication Language)
  • 288 Pages - 07/10/2023 (Publication Date) - The Healthy RD (Publisher)
No. 19
NATURELO Calcium Supplement - Bone Strength with Calcium 600mg, Vitamin D3, K2, C, Magnesium Zinc - Plant-Based, 120 Vegetarian Capsules, Non-GMO, Soy & Gluten-Free
  • CALCIUM MAGNESIUM ZINC D3 SUPPLEMENT: NATURELO Bone Strength is a calcium, magnesium and zinc supplement enriched with plant-based nutrients to support bone health*, including Calcium sourced from marine algae and Vitamin D3 from lichen.
  • VITAMIN ENRICHED CALCIUM MAGNESIUM SUPPLEMENT: Offering a comprehensive bone health nutritional formula - this calcium and magnesium supplement contains essential vitamins such as Vitamin D3, K2, and C, plus Zinc and other minerals to support bone density* and maintain bone health.*
  • ABSORPTION: This Magnesium Zinc Calcium Supplement is designed to support calcium absorption in the body, with the inclusion of Vitamin D3, Magnesium, and Vitamin K2, to help effectively directing calcium towards the bones.
  • CALCIUM 600 MG WITH VITAMIN D3: Our calcium 600 mg with Vitamin D3 supplement helps support bone health* especially important in later life stages, and in women who tend to lose more bone mass during perimenopause and menopause.
  • CLEAN AND NATURAL: As a clean-label, non-GMO calcium and Vitamin D supplement, these special vitamins for bone strength have no unnecessary additives. Free from gluten, dairy, nuts, preservatives and artificial coloring, this magnesium, calcium, zinc supplement is suitable for vegans and vegetarians.

How to choose a good multi enzymes nutritional supplements

Does the idea of finding a fantastic multi enzymes nutritional supplements make you anxious? When it comes to purchasing this product, specifically when deciding which model to select, has your head been spinning between options? You are not alone if that is the case. We are aware of the pressure involved in the purchasing process!

Your presence here indicates that you are interested in multi enzymes nutritional supplements. Before choosing which product would be the best for your needs after being inundated with information, locate a reliable source with genuine selections. You can get that information from a variety of sources, including buying guides and rating websites, word-of-mouth recommendations from friends and family, online discussion forums where users can share their own experiences, product reviews that can be found all over the internet, and YouTube channels. You can only get the right product through exhaustive analysis. But you realize that’s not always simple. In order to ease your concerns, we have taken the time to develop a list of the top multi enzymes nutritional supplements products available right now. You might be wondering how we came up with the list. How was this buying guide developed?

First, we used our algorithms to gather as much reliable data as we could about these products. To verify all the data gathered, we used both artificial intelligence and a lot of algorithms.
Then, our experts used criteria that are recognized in the business to evaluate them according to their quality to price ratio, allowing us to choose the top multi enzymes nutritional supplements on the market right now!

The selection of the goods is not arbitrary. Before creating a list, we take into account a number of factors. Below are some of the criteria discussed:

Brand Value: What happens if you choose a dubious brand just because it appears to be a good deal? So the likelihood of receiving a product with a short shelf life increases. That is due to the fact that well-known brands have a reputation to uphold, while others do not. Top multi enzymes nutritional supplements brands strive to provide some distinctive traits that set them apart from the competition. So, hopefully one or more of the items on our list will be perfect for you.

Features: Useful features are all you need, not tons of them. We consider the important aspects and select the top multi enzymes nutritional supplements based on those.

Specifications: Numbers always help you measure the quality of a product in a quantitative way. We try to find products with higher specifications, but with the right balance.

Quality: A product’s quality may always be quantified with the aid of numbers. We look for goods with better standards that strike the proper balance. The best quality product that gets highly appreciated and recommended by experienced users.

Customer ratings:  Would it be accurate to suggest that the multi enzymes nutritional supplements were used by hundreds of customers before you? Superior ratings indicate that many customers had better service.

Customer Reviews: Like ratings,  provide you with accurate and reliable information about the product from genuine customers. Customer ratings are very important to all of us because they contain accurate and reliable information about the customer service we received from several hundred customers.

Seller Rank: This is very intriguing! Not only do you need a good multi enzymes nutritional supplements, you also need a product with rising sales that is trendy. It accomplishes two goals. First, the expanding user base proves the quality of the product. Second, given that number, producers must be able to offer greater quality and after-sales support.

Value: You get what you pay for, they say, so consider the value. Cheap isn’t always good and expensive isn’t always bad. However, that does not imply that spending a lot of money on a product that is flashy but underwhelming is a good idea. Before adding them to the list, we make an effort to evaluate how much value you can get for your money from your multi enzymes nutritional supplements.

Durability: Durability and reliability are closely related concepts. You will benefit from a strong and long-lasting multi enzymes nutritional supplements for months and years to come.

Product availability: Products come and go, and new ones replace the old ones. Most likely, a few new features and required changes were made. What use is it to use a supposedly good product if the maker no longer supports it? We make an effort to highlight products that are current and offered by one or more trustworthy sellers, if not more.

Negative Reviews: Yes, we do take that into account as well! The goods with the majority of bad reviews are filtered out and disregarded when we choose the best-rated one on the market.

These are the standards by which we selected our multi enzymes nutritional supplements. Do we end our process there? Hell no. The most crucial fact about us that you should be aware of is that we regularly update our website with current and pertinent information. We have one more layer of filtration since we place the greatest importance on reader satisfaction. Please let us know if any product included here is incorrect, irrelevant, subpar, or simply out of date. We always value your opinions, and we’ll work hard to make any necessary corrections to our list in response to them.

Why should you believe us?

There are now thousands of possibilities for these products on Amazon, but choosing the best one can be difficult and time-consuming. And what multi enzymes nutritional supplements should you purchase in 2022?

This guide is the result of more than 10 years of experience in researching, testing and writing about many topics. Each member of our team is an authority in their area. We read every article we could find online and every consumer review on every retail website for seven hours. Additionally, we discovered a ton of websites that offered helpful resources, including buying tips and thorough information on multi enzymes nutritional supplements.